Drug & supplement interaction

Elemi + Riociguat

Riociguat brand name: Adempas.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Elemi and Riociguat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Elemi and Riociguat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Riociguat and Elemi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Elemi at all — not against Riociguat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Elemi safety at a glance

Elemi overall Use caution Generally used topically or aromatically with dilution; ingesting the essential oil is not considered safe.
Pregnancy Avoid Not enough safety data, so avoid during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Riociguat and Elemi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Riociguat’s Own FDA Label Lists

This is not an interaction — none of it involves Elemi. These are the most notable effects listed in the ADVERSE REACTIONS section of Riociguat’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Trouble swallowing Worth acting on
  • Anemia Worth acting on
  • Bleeding or bruising Worth acting on
  • Heartburn
  • Bloating or gas
  • A stuffy or runny nose
  • A fast or pounding heartbeat
  • Low blood pressure
  • Stomach upset
  • Constipation

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Riociguat. Read the label on DailyMed › Elemi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Elemi side to compare — that is a limit of the record, not a statement that Elemi has no side effects.

Everything else you take

See Every Supplement That Interacts With Riociguat

This page covers Elemi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Riociguat page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and St. John's Wort (major).

By severity: 6 major · 187 moderate · 37 minor.

From our pharmacist’s overview on the Riociguat page

“Riociguat (Adempas) works by relaxing the blood vessels in your lungs, which also lowers blood pressure, so I read this list of 230 supplements and herbs with real concern, and the six rated major are what to understand first. Grapefruit can push riociguat levels up and intensify its effect, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Riociguat interaction page

One more smart check

Taking Elemi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Elemi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Elemi. Even though Elemi itself has no known interaction with Riociguat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Elemi and Riociguat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Elemi
Steady interest

#799 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Riociguat
Steady interest

#2,453 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Elemi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Elemi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Elemi and Riociguat records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Elemi

What is Elemi?

  • Skin care and wound soothing
  • Aromatherapy for relaxation
  • Cough and chest congestion
  • Muscle and joint discomfort
  • Antimicrobial use (topical)

Elemi is a fragrant tree resin from the Philippines, used mainly as an essential oil in aromatherapy and topical skin and balm products. Solid human evidence for any health benefit is lacking, and like other essential oils it should never be swallowed and should be diluted before skin use. Talk to a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have sensitive skin.

Canarium luzonicum · Burseraceae · Oleoresin (gum resin) and the essential oil distilled from it · Essential oil, resin, and ingredient in salves, balms, and incense

An interaction check asks whether these two react with each other — it does not ask whether Elemi is a good idea for someone in your situation. Here is what our Elemi record says about it on its own.

Elemi: dosing

There is no established or standardized dose for elemi. For aromatherapy and topical use, the right amount depends on the product and how it is blended. Essential oils are typically diluted to a low percentage in a carrier oil before being applied to skin.Follow the directions on the specific product label, and do not assume more is better.

From our Elemi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Elemi monograph & all interactions
Medication

About Riociguat

What Is Riociguat Used For?

Brand name: Adempas

Riociguat tablets — sold as Adempas and under the generic name Riociguat — are used to treat adults with two types of pulmonary hypertension (high blood pressure in the lungs).

The first is chronic thromboembolic pulmonary hypertension (CTEPH), a condition caused by blood clots in the lung arteries, either after surgery or when surgery is not an option. The second is pulmonary arterial hypertension (PAH), where the arteries carrying blood to the lungs are narrowed or blocked. In both conditions, riociguat helps improve exercise ability and functional status, and in PAH it also helps slow the disease from getting worse.

Most-Reported Side Effects for Riociguat

From FAERS, the FDA’s public side-effect reporting system (32,415 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 5,718 reports
Headache 4,513 reports
Nausea 3,769 reports
Diarrhea 3,533 reports
Dizziness 3,522 reports
See full Riociguat drug information
Keep checking

Other Drugs & Elemi

Browse every other medication we’ve checked against Elemi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Elemi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Elemi list.

See the full Elemi interactions page
See every supplement checked against Riociguat, ranked by severity
Evidence & sources

Elemi References

The 1 sources that drive our Elemi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Elemi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Aromatherapy — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Elemi and Riociguat Together: Common Questions

Is it safe to take Elemi with Riociguat?
We do not list a known interaction between Elemi and Riociguat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Riociguat interact with any supplements?
Yes. Riociguat has documented interactions with 230 supplements in our database — Elemi is not one of them. The Riociguat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Elemi monograph Uses, safety profile, and every drug interaction in one place Riociguat drug information The full plain-English guide to this medication Riociguat supplement interactions Every supplement checked against Riociguat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Riociguat and Elemi?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.