Ergothioneine + Brexanolone
Brexanolone brand name: Zulresso.
We found no known interaction between Ergothioneine and Brexanolone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Ergothioneine and Brexanolone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Brexanolone and Ergothioneine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Ergothioneine at all — not against Brexanolone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ergothioneine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Brexanolone
This page covers Ergothioneine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brexanolone page lists 79 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major), Kava (major) and L-tryptophan (major).
By severity: 6 major · 67 moderate · 6 minor.
From our pharmacist’s overview on the Brexanolone page
“Brexanolone (Zulresso) is an IV infusion for postpartum depression, and it already carries a boxed warning for excessive sedation and sudden loss of consciousness during treatment. That built-in risk is exactly what most of these 79 supplements press on, so treat this list with genuine care.”
Reviewed by 2 · Jul 18, 2026
Taking Ergothioneine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 10 real supplement products containing Ergothioneine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ergothioneine. Even though Ergothioneine itself has no known interaction with Brexanolone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ergothioneine and Brexanolone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,143 of 1,452 supplements looked up here in the last 7 days
#825 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ergothioneine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ergothioneine and Brexanolone records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ergothioneine
What is Ergothioneine?
- Antioxidant support
- Healthy aging and longevity
- Cellular protection
- Cognitive and brain health
- General wellness
Ergothioneine is a naturally occurring amino acid–like compound (an antioxidant) found mostly in mushrooms and made by certain fungi and bacteria. Early laboratory studies suggest it may help protect cells from oxidative stress, but solid human evidence for any specific health benefit is still limited. It appears generally well tolerated, but if you are pregnant, breastfeeding, or taking other medicines, check with your pharmacist or doctor first.
Naturally found in certain mushrooms and other foods; produced by some fungi and bacteria · Capsules, tablets, powders, and as a nutrient in mushroom-based foods
An interaction check asks whether these two react with each other — it does not ask whether Ergothioneine is a good idea for someone in your situation. Here is what our Ergothioneine record says about it on its own.
Ergothioneine: dosing
There is no officially established dose for ergothioneine supplements. Doses used in research have varied, and a standard recommended amount has not been set.The safest approach is to follow the dosing on the product label and not exceed it. You can also increase your intake naturally by eating more mushrooms.
From our Ergothioneine monograph — the full record covers uses, side effects and every documented interaction.
About Brexanolone Injection
What Is Brexanolone Injection Used For?
Brand name: Zulresso
-
Brexanolone injection is used for the treatment of postpartum depression (PPD) in adults. Brexanolone injection is in a class of medications called neurosteroid antidepressants. It works by changing the activity of certain natural substances in the brain.
Other Drugs & Ergothioneine
Browse every other medication we’ve checked against Ergothioneine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Ergothioneine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ergothioneine list.
Ergothioneine References
The 2 references that drive our Ergothioneine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Benson KF, Ager DM, Landes B, Aruoma OI, Jensen GS. Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement. Prev Med. 2012;54 Suppl:S83-9. PubMed
- Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart 2019. pii: heartjnl-2019-315485. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Brexanolone Is Linked to Lower Levels of One Nutrient
Natural Medicines records Brexanolone as a medicine that can lower these. This is not an interaction with Ergothioneine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Brexanolone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Ergothioneine and Brexanolone Together: Common Questions
Is it safe to take Ergothioneine with Brexanolone?
Does Brexanolone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Brexanolone and Ergothioneine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.