Medication interaction hub

What Supplements Interact with Brexanolone?

Brexanolone brand name: Zulresso. Every interaction below applies to the brands too.

79 Interactions 6 Major 67 Moderate 6 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Brexanolone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Brexanolone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Brexanolone (Zulresso) is an IV infusion for postpartum depression, and it already carries a boxed warning for excessive sedation and sudden loss of consciousness during treatment. That built-in risk is exactly what most of these 79 supplements press on, so treat this list with genuine care. Seventy-eight of the entries are CNS depressants that can deepen sedation, and six rate major, including everyday alcohol in the form of beer and wine, along with kava.

The 67 moderate entries mostly repeat that same theme on thinner evidence, plants and compounds that cause drowsiness on their own and could stack with the infusion, while just six land in the minor category. Three ingredients act along antidepressant lines instead. Since brexanolone runs over roughly 60 hours under continuous monitoring, tell the team every supplement you have used recently and skip anything sedating in the days around your infusion.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 67 Minor 6 No known interaction 1,373

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Brexanolone: Top Interactions at a Glance

The most significant Brexanolone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 79 interacting ingredients — plus 1,373 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Brexanolone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Brexanolonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Brexanolonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Brexanolonei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Brexanolonei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Brexanolonei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction Major Likelihood Probable L-tryptophan + Brexanolonei

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Brexanolone

All 1,452 ingredients in our database, ranked by severity — 79 with a Brexanolone interaction on file and 1,373 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Brexanolone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lavender with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Brexanolone answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Brexanolone answer

Can you take Rauvolfia Vomitoria with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Brexanolone answer

Can you take Saffron with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Brexanolone answer

Can you take Sage with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Brexanolone answer

Can you take Sassafras with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Brexanolone answer

Can you take Sceletium with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Brexanolone answer

Can you take Shepherd's Purse with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Brexanolone answer

Can you take Skullcap with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Brexanolone answer

Can you take Spearmint with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Brexanolone answer

Can you take Tarragon with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Brexanolone answer

Can you take Theacrine with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Brexanolone answer

Can you take Tianeptine with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Brexanolone answer

Can you take Tree Turmeric with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Brexanolone answer

Can you take Valerian with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Brexanolone answer

Can you take Wild Lettuce with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Full Wild Lettuce + Brexanolone answer

Can you take Yin Chen with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.

Full Yin Chen + Brexanolone answer

Can you take Zizyphus with Brexanolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Brexanolone answer

Can you take Calea Zacatechichi with Brexanolone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.

Full Calea Zacatechichi + Brexanolone answer

Can you take Rhodiola with Brexanolone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.

Full Rhodiola + Brexanolone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Brexanolone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Brexanolone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Brexanolone sits in 2 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Brexanolone through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Brexanolone through this category.

About Brexanolone

Brexanolone is a prescription medication also sold under the brand name Zulresso. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Brexanolone  ·  Brand name: Zulresso.

See the full Brexanolone Injection drug information

Related: does Brexanolone deplete any nutrients?

Brexanolone has 1 reported nutrient association in the research literature — see the Brexanolone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Brexanolone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Brexanolone.

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Products that contain Brexanolone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Brexanolone.

Kava-Kava 400 mg by Signature Supplements contains Kava Kava Nectar Classic Edition by Kavahana contains Kava Zaza Red by Zaza contains Kava Mood Care by Herbal Terra contains Kava
Pharmacist Counseling Corner

Brexanolone & Supplements: Common Questions

What supplements interact with Brexanolone?
Our database currently documents 79 ingredients with a known Brexanolone interaction (6 major, 67 moderate, 6 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 79. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Brexanolone supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Gamma-hydroxybutyrate (ghb) and Kava, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Brexanolone?
Plenty of supplements coexist fine with Brexanolone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Zulresso have the same supplement interactions as Brexanolone?
Yes — Zulresso all contain Brexanolone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Brexanolone deplete any vitamins or nutrients?
It might — Brexanolone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Brexanolone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Brexanolone and my other medications?
This page covers Brexanolone against supplements and herbal ingredients. Checking Brexanolone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Brexanolone Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.