Drug & supplement interaction

European Chestnut + Revefenacin

Revefenacin brand name: Yupelri.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between European Chestnut and Revefenacin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

European Chestnut and Revefenacin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Revefenacin and European Chestnut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for European Chestnut at all — not against Revefenacin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

European Chestnut safety at a glance

European Chestnut overall Use caution The nut is a common food, but concentrated leaf or bark extracts have not been well studied for safety.
Pregnancy Avoid There is not enough safety information, so medicinal use during pregnancy is best avoided.
Breastfeeding Avoid Safety during breastfeeding is unknown, so medicinal use is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Revefenacin and European Chestnut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Revefenacin’s Own FDA Label Lists

This is not an interaction — none of it involves European Chestnut. These are the most notable effects listed in the ADVERSE REACTIONS section of Revefenacin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Trouble passing urine Worth acting on
  • Wheezing Worth acting on
  • Raised blood pressure Worth acting on
  • A higher chance of infection Worth acting on mentioned in 5.8% of FDA reports for Revefenacin
  • An allergic reaction Worth acting on
  • Cough mentioned in 6.8% of FDA reports for Revefenacin
  • Sore throat
  • Dry mouth
  • Back pain
  • Headache mentioned in 6.6% of FDA reports for Revefenacin

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Revefenacin. Read the label on DailyMed › Where a percentage is shown, it is the share of 740 voluntary FDA FAERS reports for Revefenacin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. European Chestnut’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no European Chestnut side to compare — that is a limit of the record, not a statement that European Chestnut has no side effects.

Overlapping uses

What Revefenacin Is Prescribed For, and What European Chestnut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Revefenacin is a prescription medicine with approved uses on its FDA label. European Chestnut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Revefenacin is prescribed for: Yupelri (revefenacin) inhalation solution is approved for the maintenance treatment of COPD (chronic obstructive pulmonary disease) in adults. It is used every day to help keep airways open and make breathing easier over the long term. Yupelri is not a rescue inhaler — it will not relieve a sudden COPD flare-up or acute breathing attack. A separate short-acting bronchodilator is needed for those situations.

European Chestnut has been studied for:

  • Bronchitis studied, not established European Chestnut has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    European Chestnut for bronchitis

    Although there is interest in using oral European chestnut for bronchitis, there is insufficient reliable information about the clinical effects of European chestnut for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Revefenacin on your own; if you are taking European Chestnut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Revefenacin

This page covers European Chestnut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Revefenacin page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Revefenacin page

“Revefenacin (Yupelri) is an inhaled anticholinergic that keeps airways open in COPD, and this list warrants genuine care rather than a quick skim. Of the 46 supplements on file, three carry a major rating, and most of the rest share revefenacin's drying, anticholinergic action, so combining them can stack up dry mouth, blurred vision,…”

Reviewed by 2 · Jul 18, 2026

Open the Revefenacin interaction page

How much people look this up

Where European Chestnut and Revefenacin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement European Chestnut
Steady interest

#1,227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Revefenacin
Steady interest

#1,454 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every European Chestnut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The European Chestnut and Revefenacin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About European Chestnut

What is European Chestnut?

  • Coughs and respiratory irritation
  • Diarrhea and digestive upset
  • Sore throat
  • Wound and skin care
  • General antioxidant support

European Chestnut is a tree whose leaves and nuts have a long history of use for coughs, diarrhea, and skin care, mostly in traditional folk medicine. High-quality human studies are lacking, so its benefits remain unproven, and it should be used cautiously and discussed with a pharmacist or doctor.

Castanea sativa · Fagaceae · Leaves, nuts (seeds), bark, and flowers · Tea, liquid extract, capsules, honey, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether European Chestnut is a good idea for someone in your situation. Here is what our European Chestnut record says about it on its own.

European Chestnut: dosing

There is no standardized or well-established medicinal dose for European Chestnut. Products vary widely in strength and in which part of the plant they use.If you choose to use a chestnut product, follow the directions on the label and do not exceed the recommended amount.

From our European Chestnut monograph — the full record covers uses, side effects and every documented interaction.

Read the full European Chestnut monograph & all interactions
Medication

About Revefenacin Oral Inhalation

What Is Revefenacin Oral Inhalation Used For?

Brand name: Yupelri

Yupelri (revefenacin) inhalation solution is approved for the maintenance treatment of COPD (chronic obstructive pulmonary disease) in adults. It is used every day to help keep airways open and make breathing easier over the long term.

Yupelri is not a rescue inhaler — it will not relieve a sudden COPD flare-up or acute breathing attack. A separate short-acting bronchodilator is needed for those situations.

See full Revefenacin Oral Inhalation drug information
Keep checking

Other Drugs & European Chestnut

Browse every other medication we’ve checked against European Chestnut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked European Chestnut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full European Chestnut list.

See the full European Chestnut interactions page
See every supplement checked against Revefenacin, ranked by severity
Evidence & sources

European Chestnut References

The 1 references that drive our European Chestnut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking European Chestnut and Revefenacin Together: Common Questions

Is it safe to take European Chestnut with Revefenacin?
We do not list a known interaction between European Chestnut and Revefenacin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are European Chestnut and Revefenacin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for European Chestnut in each. That is a conversation for your prescriber, especially if Revefenacin is being adjusted to a target.
Does Revefenacin interact with any supplements?
Yes. Revefenacin has documented interactions with 46 supplements in our database — European Chestnut is not one of them. The Revefenacin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

European Chestnut monograph Uses, safety profile, and every drug interaction in one place Revefenacin Oral Inhalation drug information The full plain-English guide to this medication Revefenacin supplement interactions Every supplement checked against Revefenacin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Revefenacin and European Chestnut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.