Herb & supplement monograph

Samphire Drug Interactions, Uses, Effectiveness, Safety & More

Check Samphire against your medication

Add one medication
Samphire
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Samphire

0 medications have a known interaction with Samphire, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Samphire. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Samphire combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Samphire: Uses, Safety & Side Effects

The bottom line

Samphire is a salt-tolerant coastal plant eaten as a vegetable, prized for its crisp, salty taste and its nutrients like vitamins and minerals. There is very little human research supporting any specific health benefit beyond its value as a food, so it should be enjoyed mainly as a food rather than relied on as a medicine. If you are pregnant, breastfeeding, or watching your salt intake, talk to a pharmacist or doctor first.

Part used
Young stems and leaves (sometimes the whole above-ground plant)
Common forms
Fresh vegetable, pickled, dried, powder, and occasionally as an extract
People commonly use it for
  • Culinary vegetable and seasoning
  • Source of vitamins and minerals
  • Digestive health
  • Traditional skin and antioxidant uses
  • Salt substitute or low-sodium flavoring

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as a food, but it can be high in sodium and is poorly studied as a supplement.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Samphire is the common name for several edible, salt-loving plants that grow along coastlines, marshes, and rocky shores. Two main types are often sold: marsh samphire (also called glasswort or sea bean), which has crunchy green stems, and rock samphire, which grows on cliffs and has fleshy leaves. Because the plants tolerate salty soil and seawater, they naturally have a salty, fresh taste.

It is most often used as a food. People steam it, sauté it, eat it raw in salads, or pickle it. In some coastal traditions it has also been used as a folk remedy and as a natural source of minerals. Today you may also see it sold dried or as a powder marketed as a health supplement.

How it works

Samphire contains a mix of nutrients, including vitamins, minerals (such as sodium and iodine, which it takes up from seawater), fiber, and natural plant compounds like polyphenols and flavonoids. These plant compounds can act as antioxidants in laboratory tests, meaning they may help neutralize unstable molecules called free radicals.

Researchers have studied extracts of samphire in test tubes and animals for possible antioxidant and anti-inflammatory effects. These are early, preliminary findings. It is not clear whether eating normal amounts of samphire produces meaningful effects in the human body, and the active compounds and doses have not been well defined.

Effectiveness

Does Samphire work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Samphire, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Scurvy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral samphire for scurvy due to its vitamin C content, there is insufficient reliable information about the clinical effects of samphire for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a food eaten in normal amounts, samphire is generally considered safe for most healthy people. The biggest practical concern is its salt (sodium) content, especially in pickled forms. If you have high blood pressure, heart failure, kidney disease, or have been told to limit salt, be careful with how much you eat and check with your doctor or pharmacist.

Because some samphire grows in coastal water, it can absorb iodine and possibly environmental pollutants depending on where it was harvested. People with thyroid conditions should be mindful of iodine intake. Choose products from reputable sources.

Pregnancy and breastfeeding: Eating small culinary amounts is likely fine, but concentrated supplements, extracts, or powders have not been studied for safety. To be cautious, avoid supplement-strength samphire during pregnancy and breastfeeding unless your healthcare provider approves.

Side effects

For most people, samphire eaten as a vegetable causes few problems. Possible issues include:

  • Too much salt intake, which can raise blood pressure or cause fluid retention, especially with pickled samphire.
  • Mild digestive upset, such as bloating, in some people.
  • Possible allergic reaction, though this appears uncommon.

There is little information on side effects from concentrated supplements because they have not been well studied. Stop using it and seek medical care if you notice signs of an allergic reaction, such as rash, swelling, or trouble breathing.

Dosing

There is no established medicinal dose for samphire. As a food, people simply eat it as a vegetable in normal portions. For any supplement, powder, or extract, follow the directions on the product label.

Because product strength and quality vary and the health benefits are not proven, it is best to check with a pharmacist or doctor before taking samphire supplements, particularly if you have a medical condition or take medications.

Pregnancy & Breastfeeding

Samphire & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Samphire & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 sources that drive our Samphire monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Sodium in Your Diet — U.S. Food and Drug Administration (FDA) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Herbal Supplements — MedlinePlus (NIH) Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Brand directory

Brands that make products with Samphire

1 brand in our database make a supplement containing Samphire.

Pharmacist Counseling Corner

Samphire: Common Questions

What is Samphire used for, and does it work?
People use Samphire for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Samphire interact with prescription medications?
We do not currently list any known drug interactions for Samphire. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Samphire interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Samphire with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Samphire interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Samphire used for?
Samphire is mainly used as a salty, crunchy vegetable in cooking. Some people also take it for its vitamins, minerals, and antioxidant plant compounds, but strong human evidence for specific health benefits is lacking.
Is Samphire safe to eat?
For most healthy people, Samphire is safe as a food in normal amounts. The main caution is its salt content, so people watching their sodium or with high blood pressure, heart, or kidney problems should be careful.
Can I eat Samphire while pregnant or breastfeeding?
Small amounts as a food are likely okay, but supplements, extracts, or powders have not been studied during pregnancy or breastfeeding. To be safe, avoid concentrated Samphire products and check with your doctor or pharmacist first.
Is Samphire high in salt?
Yes, Samphire naturally absorbs salt from its coastal environment and tastes salty, and pickled versions can be especially high in sodium. Keep this in mind if you are limiting your salt intake.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Samphire

A rotating sample of real supplements in our database that list Samphire — open any to see its full ingredients and every drug interaction we check.

Have a question about Samphire?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist