Samphire Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Samphire interacts with medications. The heart of this page is the interaction list — every drug Samphire is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Samphire is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Samphire against your medication
Add one medicationDrugs that interact with Samphire
0 medications have a known interaction with Samphire, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Samphire. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Samphire combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Samphire: Uses, Safety & Side Effects
Samphire is a salt-tolerant coastal plant eaten as a vegetable, prized for its crisp, salty taste and its nutrients like vitamins and minerals. There is very little human research supporting any specific health benefit beyond its value as a food, so it should be enjoyed mainly as a food rather than relied on as a medicine. If you are pregnant, breastfeeding, or watching your salt intake, talk to a pharmacist or doctor first.
- Part used
- Young stems and leaves (sometimes the whole above-ground plant)
- Common forms
- Fresh vegetable, pickled, dried, powder, and occasionally as an extract
- Culinary vegetable and seasoning
- Source of vitamins and minerals
- Digestive health
- Traditional skin and antioxidant uses
- Salt substitute or low-sodium flavoring
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as a food, but it can be high in sodium and is poorly studied as a supplement.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Samphire is the common name for several edible, salt-loving plants that grow along coastlines, marshes, and rocky shores. Two main types are often sold: marsh samphire (also called glasswort or sea bean), which has crunchy green stems, and rock samphire, which grows on cliffs and has fleshy leaves. Because the plants tolerate salty soil and seawater, they naturally have a salty, fresh taste.
It is most often used as a food. People steam it, sauté it, eat it raw in salads, or pickle it. In some coastal traditions it has also been used as a folk remedy and as a natural source of minerals. Today you may also see it sold dried or as a powder marketed as a health supplement.
How it works
Samphire contains a mix of nutrients, including vitamins, minerals (such as sodium and iodine, which it takes up from seawater), fiber, and natural plant compounds like polyphenols and flavonoids. These plant compounds can act as antioxidants in laboratory tests, meaning they may help neutralize unstable molecules called free radicals.
Researchers have studied extracts of samphire in test tubes and animals for possible antioxidant and anti-inflammatory effects. These are early, preliminary findings. It is not clear whether eating normal amounts of samphire produces meaningful effects in the human body, and the active compounds and doses have not been well defined.
Does Samphire work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Samphire, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Scurvy
Although there has been interest in using oral samphire for scurvy due to its vitamin C content, there is insufficient reliable information about the clinical effects of samphire for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food eaten in normal amounts, samphire is generally considered safe for most healthy people. The biggest practical concern is its salt (sodium) content, especially in pickled forms. If you have high blood pressure, heart failure, kidney disease, or have been told to limit salt, be careful with how much you eat and check with your doctor or pharmacist.
Because some samphire grows in coastal water, it can absorb iodine and possibly environmental pollutants depending on where it was harvested. People with thyroid conditions should be mindful of iodine intake. Choose products from reputable sources.
Pregnancy and breastfeeding: Eating small culinary amounts is likely fine, but concentrated supplements, extracts, or powders have not been studied for safety. To be cautious, avoid supplement-strength samphire during pregnancy and breastfeeding unless your healthcare provider approves.
Side effects
For most people, samphire eaten as a vegetable causes few problems. Possible issues include:
- Too much salt intake, which can raise blood pressure or cause fluid retention, especially with pickled samphire.
- Mild digestive upset, such as bloating, in some people.
- Possible allergic reaction, though this appears uncommon.
There is little information on side effects from concentrated supplements because they have not been well studied. Stop using it and seek medical care if you notice signs of an allergic reaction, such as rash, swelling, or trouble breathing.
Dosing
There is no established medicinal dose for samphire. As a food, people simply eat it as a vegetable in normal portions. For any supplement, powder, or extract, follow the directions on the product label.
Because product strength and quality vary and the health benefits are not proven, it is best to check with a pharmacist or doctor before taking samphire supplements, particularly if you have a medical condition or take medications.
Samphire & Pregnancy
Samphire & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 sources that drive our Samphire monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Sodium in Your Diet — U.S. Food and Drug Administration (FDA) Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
- Herbal Supplements — MedlinePlus (NIH) Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Brands that make products with Samphire
1 brand in our database make a supplement containing Samphire.
Supplement products with Samphire
3 products in our database contain Samphire. Open any to see its full ingredient list and every drug interaction we check.
Samphire: Common Questions
What is Samphire used for, and does it work?
Does Samphire interact with prescription medications?
How are Samphire interactions rated?
Is it safe to take Samphire with my medications?
Where does this Samphire interaction information come from?
What is Samphire used for?
Is Samphire safe to eat?
Can I eat Samphire while pregnant or breastfeeding?
Is Samphire high in salt?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Samphire
A rotating sample of real supplements in our database that list Samphire — open any to see its full ingredients and every drug interaction we check.
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