Drug & supplement interaction

Fig + Letrozole

Letrozole brand name: Femara.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fig and Letrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fig and Letrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Letrozole and Fig in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fig safety at a glance

Fig overall Generally safe Fig fruit is a safe food for most people; concentrated leaf products are less studied.
Pregnancy Likely Safe When the fresh or dried fruit is used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of fig le... Read the full pregnancy detail
Breastfeeding Likely Safe When the fresh or dried fruit is used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of fig le... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Letrozole and Fig? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Letrozole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Letrozole is filed under 4 classifications — including aromatase inhibitors, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates. Fig has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), insulin (moderate) and photosensitizing drugs (moderate) — and none of Letrozole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fig Does Interact With Other Medications

Fig has 410 moderate known drug interactions in our database — Letrozole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 410 No known interaction 2,420 (incl. Letrozole)
Taking anything else?

Check Another of Your Medications Against Fig

Covers the 2,830 medications we’ve checked against Fig. Pick one to open its full report.

What to actually watch for

What Fig Itself Has Been Linked To

This is not an interaction — nothing below involves Letrozole. It is the side-effect record for Fig on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fig, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Anemia / A higher chance of infection Worth acting on Additional detail

    “Topically, fig leaf might cause photodermatitis. The leaf contains psoralens. Many cases of photodermatitis from fig leaf have been reported. In at least two cases, the burns were serious enough to require hospitalization. Severe anemia and sepsis developed in one patient,.”

    Fig · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 12579. Rubnov S, Kashman Y, Rabinowitz R, et al. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. J Nat Prod 2001;64:993-6.
    2. 12581. Zaynoun ST, Aftimos BG, Abi Ali L, et al. Ficus carica; isolation and quantification of the photoactive components. Contact Dermatitis 1984;11:21-5.
    3. 49962. Bollero, D., Stella, M., Rivolin, A., Cassano, P., Risso, D., and Vanzetti, M. Fig leaf tanning lotion and sun-related burns: case reports. Burns 2001;27(7):777-779. PubMed
    4. 49968. Ozdamar, E., Ozbek, S., and Akin, S. An unusual cause of burn injury: fig leaf decoction used as a remedy for a dermatitis of unknown etiology. J.Burn Care Rehabil. 2003;24(4):229-233. PubMed
    5. 49973. Munteanu, M. Contact dermatitis to the sap of fig-tree. Rev.Med.Chir Soc.Med.Nat.Iasi 1989;93(3):602.
    6. 49975. Lembo, G., Lo, Presti M., and Balato, N. Phytophotodermatitis due to ficus carica. Photodermatol. 1985;2(2):119-120.
  • A severe allergic reaction Worth acting on Additional detail

    “Orally, the fresh or dried fig fruit is well tolerated in amounts commonly found in foods. A thorough evaluation of safety outcomes has not been conducted when fig fruit is used orally as medicine.

    Topically, fig leaf may cause photodermatitis.”

    Fig · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    “Orally, fig fruit can cause allergy and, in rare cases, anaphylaxis. Topically, exposure to fig fruit and leaves can cause contact dermatitis. In some cases, sun exposure can make contact dermatitis worse.”

    Fig · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 8815. Gandolfo M, Baeza M, De Barrio M, Anaphylaxis after eating figs. Allergy 2001;56:462-3. PubMed
    2. 12580. Dechamp C, Bessot JC, Pauli G, Deviller P. First report of anaphylactic reaction after fig (Ficus carica) ingestion. Allergy 1995;50:514-6.
    3. 12689. Lembo G, Lo Presti M, Balato N. Phytophotodermatitis due to ficus carica. Photodermatol 1985;2:119-20.
    4. 99961. Bonamonte D, Foti C, Lionetti N, Rigano L, Angelini G. Photoallergic contact dermatitis to 8-methoxypsoralen in Ficus carica. Contact Dermatitis. 2010;62(6):343-8.
  • A skin rash Additional detail

    Recorded for Fig in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Fig — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Letrozole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Letrozole column appears here.

Special populations

Fig in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When the fresh or dried fruit is used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of fig leaf or fruit used in medicinal amounts during pregnancy and lactation; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fig or Letrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fig or Letrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Letrozole

This page covers Fig only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 7-methoxyflavone (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 99 moderate · 40 minor.

From our pharmacist’s overview on the Letrozole page

“Letrozole (Femara) is prescribed to keep hormone-driven breast cancer from returning, so a supplement that shifts its blood level can quietly undercut treatment. Give this list of 142 ingredients genuine respect, and learn the three major entries first.”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole interaction page

One more smart check

Taking Fig as Part of a Dietary Supplement Product? Check It for Interactions

We hold 189 real supplement products containing Fig, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fig. Even though Fig itself has no known interaction with Letrozole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fig and Letrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fig
Steady interest

#768 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole
Top 5%

#50 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fig reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fig and Letrozole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fig

What is Fig?

  • Constipation and digestive health
  • Blood sugar support
  • Cough and sore throat
  • Skin conditions (topical sap)
  • Source of fiber and minerals

Fig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally for blood sugar and coughs. The fruit is a safe and nutritious food, but evidence for fig leaf supplements treating specific health conditions is limited. Talk to your pharmacist or doctor before using concentrated fig leaf products, especially if you have diabetes.

Ficus carica · Moraceae · Fruit, leaves, and latex (sap) · Fresh or dried fruit, leaf tea, leaf extract, syrup, capsules

An interaction check asks whether these two react with each other — it does not ask whether Fig is a good idea for someone in your situation. Here is what our Fig record says about it on its own.

Fig: dosing

There is no official standardized dose for fig as a medicine. As a food, people commonly eat a few dried or fresh figs for fiber and to help with constipation.For fig leaf teas, extracts, or capsules, no well-established medicinal dose exists. If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Fig monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fig monograph & all interactions
Medication

About Letrozole

What Is Letrozole Used For?

Brand name: Femara

Letrozole (brand name Femara) is used to treat breast cancer in postmenopausal women whose tumors are driven by estrogen. It is used in three settings: as adjuvant (after-surgery) treatment for hormone receptor positive early breast cancer; as extended adjuvant treatment for women who have already completed about five years of tamoxifen therapy; and as first- or second-line treatment for locally advanced or metastatic (spread) breast cancer.

Femara is specifically indicated for first-line treatment of hormone receptor positive or receptor-unknown locally advanced or metastatic breast cancer, and for advanced breast cancer in women whose disease has progressed after antiestrogen therapy.

See full Letrozole drug information
Keep checking

Other Drugs & Fig

Browse every other medication we’ve checked against Fig — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
410Moderate
0Minor
2,419No known interaction
410 Moderate 2,419 No interaction
Moderate

410 interactions

Showing 60 of 410 moderate interactions — see all 410 on the Fig page.

No interaction 2,419 drugs checked — show the list

We also checked Fig against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,419 medications checked with no known interaction — see the full Fig list.

See the full Fig interactions page
See every supplement checked against Letrozole, ranked by severity
Evidence & sources

Fig References

The 13 references that drive our Fig monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gandolfo M, Baeza M, De Barrio M, Anaphylaxis after eating figs. Allergy 2001;56:462-3. PubMed
  2. Serraclara A, Hawkins F, Perez C, et al. Hypoglycemic action of an oral fig-leaf decoction in type-I diabetic patients. Diabetes Res Clin Pract 1998;39:19-22. PubMed
  3. Rubnov S, Kashman Y, Rabinowitz R, et al. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. J Nat Prod 2001;64:993-6.
  4. Dechamp C, Bessot JC, Pauli G, Deviller P. First report of anaphylactic reaction after fig (Ficus carica) ingestion. Allergy 1995;50:514-6.
  5. Zaynoun ST, Aftimos BG, Abi Ali L, et al. Ficus carica; isolation and quantification of the photoactive components. Contact Dermatitis 1984;11:21-5.
  6. Lembo G, Lo Presti M, Balato N. Phytophotodermatitis due to ficus carica. Photodermatol 1985;2:119-20.
  7. Bollero, D., Stella, M., Rivolin, A., Cassano, P., Risso, D., and Vanzetti, M. Fig leaf tanning lotion and sun-related burns: case reports. Burns 2001;27(7):777-779. PubMed
  8. Ozdamar, E., Ozbek, S., and Akin, S. An unusual cause of burn injury: fig leaf decoction used as a remedy for a dermatitis of unknown etiology. J.Burn Care Rehabil. 2003;24(4):229-233. PubMed
  9. Munteanu, M. Contact dermatitis to the sap of fig-tree. Rev.Med.Chir Soc.Med.Nat.Iasi 1989;93(3):602.
  10. Lembo, G., Lo, Presti M., and Balato, N. Phytophotodermatitis due to ficus carica. Photodermatol. 1985;2(2):119-120.
  11. Micali, G., Nasca, M. R., and Musumeci, M. L. Severe phototoxic reaction secondary to the application of a fig leaves' decoction used as a tanning agent. Contact Dermatitis 1995;33(3):212-213. PubMed
  12. Bonamonte D, Foti C, Lionetti N, Rigano L, Angelini G. Photoallergic contact dermatitis to 8-methoxypsoralen in Ficus carica. Contact Dermatitis. 2010;62(6):343-8.
  13. Pinto AR, Machado Cunha I, Rebelo Gomes E. Fig Tree-Induced Phytophotodermatitis: A Case Report on the Perils of a Hobby. Cureus 2023;15(7):e41888. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fig and Letrozole Together: Common Questions

Is it safe to take Fig with Letrozole?
We do not list a known interaction between Fig and Letrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Fig and Letrozole combination checked?
Interactions in our licensed database are recorded against drug classes. Letrozole is filed under 4 classifications, and Fig has documented interactions with 3 drug classes — none of Letrozole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fig interact with any other medications?
Yes. Fig has 410 documented drug interactions in our database — Letrozole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Letrozole interact with any supplements?
Yes. Letrozole has documented interactions with 142 supplements in our database — Fig is not one of them. The Letrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fig monograph Uses, safety profile, and every drug interaction in one place Letrozole drug information The full plain-English guide to this medication Letrozole supplement interactions Every supplement checked against Letrozole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Letrozole and Fig?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.