Drug & supplement interaction

Fish Therapy + Cetirizine Hydrochloride

Cetirizine Hydrochloride brand name: Zerviate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fish Therapy and Cetirizine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fish Therapy and Cetirizine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cetirizine Hydrochloride and Fish Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Fish Therapy alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Fish Therapy at all — not against Cetirizine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Fish Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fish Therapy safety at a glance

Fish Therapy overall Use caution Hygiene and infection risks make this a cautious choice, especially with shared water.
Pregnancy Use caution Not studied in pregnancy; avoid due to infection risk unless cleared by your doctor.
Breastfeeding Use caution No safety data; infection risk makes caution reasonable while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cetirizine Hydrochloride and Fish Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Fish Therapy Itself Has Been Linked To

This is not an interaction — nothing below involves Cetirizine Hydrochloride. It is the side-effect record for Fish Therapy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fish Therapy, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Liver problems / A higher chance of infection Worth acting on Additional detail

    “Multiple case reports suggest that fish therapy can increase the risk for bacterial infection. Studies of fish therapy water have identified multiple bacteria capable of causing disease. It is currently not possible to adequately sterilize the water without killing the fish. Additionally, when performed in a spa or salon setting, pedicure tubs cannot be adequately cleaned when fish are present.”

    Fish Therapy · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 103109. Vanhooteghem O, Anseeuw D, Michel C, et al. Fish Pedicure-induced Aeromonas sobria Superficial Necrotic Bullous Dermatitis in a Previously Undiagnosed Diabetes Patient. What are the Risks of Fish Pedicure for Public Health? BJMMR. 2015;10(12):1-10. DOI
    2. 103110. Veraldi S, Nazzaro G, Çuka E. Staphylococcus aureus infection of the feet following fish pedicure. Infection. 2014 Oct;42(5):925-6. PubMed
    3. 103111. Sugimoto K, Frei R, Graber P. Methicillin-resistant Staphylococcus aureus foot infection after fish pedicure. Infection. 2013 Oct;41(5):1013-5. PubMed
    4. 103112. Vanhooteghem O, Theate I. Fish pedicure-induced foot mycobacteriosis infection due to Mycobacterium marinum: a first case report. Eur J Dermatol. 2017 Jun 1;27(3):299-300. PubMed
    5. 103108. Lipner SR. Onychomadesis Following a Fish Pedicure. JAMA Dermatol. 2018 Sep 1;154(9):1091-1092. PubMed
    6. 103113. US Centers for Disease Control (CDC). Fish Pedicures and Fish Spas. August 2, 2016. Available at: https://www.cdc.gov/healthywater/hygiene/body/fish_pedicures.html. Accessed on June 15, 2020.
  • Swelling / A skin rash Additional detail

    Recorded for Fish Therapy in the same Natural Medicines adverse-effect record shown under Liver problems / A higher chance of infection above.

Everything above comes from the Natural Medicines adverse-effect record for Fish Therapy — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Cetirizine Hydrochloride’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Cetirizine Hydrochloride column appears here.

Everything else you take

See Every Supplement That Interacts With Cetirizine Hydrochloride

This page covers Fish Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cetirizine Hydrochloride page lists 5 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (moderate), Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate), Wine (moderate) and Alchemilla (minor).

By severity: 4 moderate · 1 minor.

Open the Cetirizine Hydrochloride interaction page

How much people look this up

Where Fish Therapy and Cetirizine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fish Therapy
Steady interest

#1,018 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cetirizine Hydrochloride
Top 5%

#141 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fish Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fish Therapy and Cetirizine Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Fish Therapy

What is Fish Therapy?

  • Psoriasis
  • Skin exfoliation and smoothing
  • Eczema and dry skin
  • Cosmetic foot care (pedicure)
  • General relaxation

Fish therapy (also called ichthyotherapy or a 'fish pedicure') uses small Garra rufa fish to nibble away dead skin, and it is mostly used cosmetically or for skin conditions like psoriasis. Evidence that it treats any medical condition is very limited, and there are real infection and hygiene concerns. If you have a skin condition, talk with a dermatologist before trying it.

Live fish (commonly Garra rufa); the whole animal used in skin-immersion baths · Spa fish baths (foot or full-body immersion with Garra rufa fish)

An interaction check asks whether these two react with each other — it does not ask whether Fish Therapy is a good idea for someone in your situation. Here is what our Fish Therapy record says about it on its own.

Fish Therapy: dosing

There is no standard 'dose' for fish therapy, since it is a spa procedure rather than a supplement you take. Sessions are usually a set number of minutes in a spa setting.If you choose to try it, only use a reputable, licensed facility that follows strict hygiene rules, and never share water with someone who has a skin infection.

From our Fish Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fish Therapy monograph & all interactions
Medication

About Cetirizine Ophthalmic

What Is Cetirizine Ophthalmic Used For?

Brand name: Zerviate

Zerviate (cetirizine ophthalmic solution) 0.24% is used to relieve eye itching caused by allergic conjunctivitis — an allergic reaction that makes the eyes red, itchy, and irritated.

Most-Reported Side Effects for Cetirizine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (166,310 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 18,984 reports
Rash 13,524 reports
Headache 12,772 reports
Pruritus 12,668 reports
Nausea 11,971 reports
See full Cetirizine Ophthalmic drug information
Keep checking

Other Drugs & Fish Therapy

Browse every other medication we’ve checked against Fish Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fish Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fish Therapy list.

See the full Fish Therapy interactions page
See every supplement checked against Cetirizine Hydrochloride, ranked by severity
Evidence & sources

Fish Therapy References

The 8 references that drive our Fish Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Grassberger M, Hoch W. Ichthyotherapy as alternative treatment for patients with psoriasis: a pilot study. Evid Based Complement Alternat Med. 2006 Dec;3(4):483-8. PubMed
  2. Lipner SR. Onychomadesis Following a Fish Pedicure. JAMA Dermatol. 2018 Sep 1;154(9):1091-1092. PubMed
  3. Vanhooteghem O, Anseeuw D, Michel C, et al. Fish Pedicure-induced Aeromonas sobria Superficial Necrotic Bullous Dermatitis in a Previously Undiagnosed Diabetes Patient. What are the Risks of Fish Pedicure for Public Health? BJMMR. 2015;10(12):1-10. DOI
  4. Veraldi S, Nazzaro G, Çuka E. Staphylococcus aureus infection of the feet following fish pedicure. Infection. 2014 Oct;42(5):925-6. PubMed
  5. Sugimoto K, Frei R, Graber P. Methicillin-resistant Staphylococcus aureus foot infection after fish pedicure. Infection. 2013 Oct;41(5):1013-5. PubMed
  6. Vanhooteghem O, Theate I. Fish pedicure-induced foot mycobacteriosis infection due to Mycobacterium marinum: a first case report. Eur J Dermatol. 2017 Jun 1;27(3):299-300. PubMed
  7. US Centers for Disease Control (CDC). Fish Pedicures and Fish Spas. August 2, 2016. Available at: https://www.cdc.gov/healthywater/hygiene/body/fish_pedicures.html. Accessed on June 15, 2020.
  8. Vanhooteghem O, Theate I, De Schaetzen V. Periungual Mycobacterium marinum Infection following a Fish Manicure. Skin Appendage Disord. 2021 Aug;7(5):393-396.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Fish Therapy While Taking Cetirizine Hydrochloride: Common Questions

Is it safe to have Fish Therapy while taking Cetirizine Hydrochloride?
We do not list a known interaction between Fish Therapy and Cetirizine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Cetirizine Hydrochloride interact with any supplements?
Yes. Cetirizine Hydrochloride has documented interactions with 5 supplements in our database — Fish Therapy is not one of them. The Cetirizine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fish Therapy monograph Uses, safety profile, and every drug interaction in one place Cetirizine Ophthalmic drug information The full plain-English guide to this medication Cetirizine Hydrochloride supplement interactions Every supplement checked against Cetirizine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cetirizine Hydrochloride and Fish Therapy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.