Fish Therapy + Dextromethorphan HBr, Guaifenesin
Dextromethorphan HBr, Guaifenesin brand names: Vicks Formula 44E Cough & Chest Congestion Relief, Pediatric Vicks Formula 44e Cough & Chest Congesti.
We found no known interaction between Fish Therapy and Dextromethorphan HBr, Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Fish Therapy and Dextromethorphan HBr, Guaifenesin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dextromethorphan HBr, Guaifenesin and Fish Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Fish Therapy alongside specific medications may be limited.
Worth understanding: our licensed dataset holds no drug-interaction record for Fish Therapy at all — not against Dextromethorphan HBr, Guaifenesin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
Fish Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Fish Therapy safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Dextromethorphan HBr, Guaifenesin
This page covers Fish Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan HBr, Guaifenesin page lists 171 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).
By severity: 4 major · 125 moderate · 42 minor.
From our pharmacist’s overview on the Dextromethorphan HBr, Guaifenesin page
“A bad cough tends to hit when supplements are already on the counter, and anyone reaching for Vicks Formula 44E (dextromethorphan HBr and guaifenesin) should treat this list with real care, since 4 of its 171 entries carry a major rating. Two themes dominate.”
Reviewed by 2 · Jul 18, 2026
Where Fish Therapy and Dextromethorphan HBr, Guaifenesin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#855 of 1,452 supplements looked up here in the last 7 days
#718 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fish Therapy reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fish Therapy and Dextromethorphan HBr, Guaifenesin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Fish Therapy
What is Fish Therapy?
- Psoriasis
- Skin exfoliation and smoothing
- Eczema and dry skin
- Cosmetic foot care (pedicure)
- General relaxation
Fish therapy (also called ichthyotherapy or a 'fish pedicure') uses small Garra rufa fish to nibble away dead skin, and it is mostly used cosmetically or for skin conditions like psoriasis. Evidence that it treats any medical condition is very limited, and there are real infection and hygiene concerns. If you have a skin condition, talk with a dermatologist before trying it.
Live fish (commonly Garra rufa); the whole animal used in skin-immersion baths · Spa fish baths (foot or full-body immersion with Garra rufa fish)
An interaction check asks whether these two react with each other — it does not ask whether Fish Therapy is a good idea for someone in your situation. Here is what our Fish Therapy record says about it on its own.
Fish Therapy: dosing
There is no standard 'dose' for fish therapy, since it is a spa procedure rather than a supplement you take. Sessions are usually a set number of minutes in a spa setting.If you choose to try it, only use a reputable, licensed facility that follows strict hygiene rules, and never share water with someone who has a skin infection.
From our Fish Therapy monograph — the full record covers uses, side effects and every documented interaction.
About Dextromethorphan HBr, Guaifenesin
Most-Reported Side Effects for Dextromethorphan HBr, Guaifenesin
From FAERS, the FDA’s public side-effect reporting system (1,675 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Fish Therapy
Browse every other medication we’ve checked against Fish Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Fish Therapy against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Bupropion ›
- Amoxicillin ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fish Therapy list.
Fish Therapy References
The 8 references that drive our Fish Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Grassberger M, Hoch W. Ichthyotherapy as alternative treatment for patients with psoriasis: a pilot study. Evid Based Complement Alternat Med. 2006 Dec;3(4):483-8. PubMed
- Lipner SR. Onychomadesis Following a Fish Pedicure. JAMA Dermatol. 2018 Sep 1;154(9):1091-1092. PubMed
- Vanhooteghem O, Anseeuw D, Michel C, et al. Fish Pedicure-induced Aeromonas sobria Superficial Necrotic Bullous Dermatitis in a Previously Undiagnosed Diabetes Patient. What are the Risks of Fish Pedicure for Public Health? BJMMR. 2015;10(12):1-10. DOI
- Veraldi S, Nazzaro G, Çuka E. Staphylococcus aureus infection of the feet following fish pedicure. Infection. 2014 Oct;42(5):925-6. PubMed
- Sugimoto K, Frei R, Graber P. Methicillin-resistant Staphylococcus aureus foot infection after fish pedicure. Infection. 2013 Oct;41(5):1013-5. PubMed
- Vanhooteghem O, Theate I. Fish pedicure-induced foot mycobacteriosis infection due to Mycobacterium marinum: a first case report. Eur J Dermatol. 2017 Jun 1;27(3):299-300. PubMed
- US Centers for Disease Control (CDC). Fish Pedicures and Fish Spas. August 2, 2016. Available at: https://www.cdc.gov/healthywater/hygiene/body/fish_pedicures.html. Accessed on June 15, 2020.
- Vanhooteghem O, Theate I, De Schaetzen V. Periungual Mycobacterium marinum Infection following a Fish Manicure. Skin Appendage Disord. 2021 Aug;7(5):393-396.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Having Fish Therapy While Taking Dextromethorphan HBr, Guaifenesin: Common Questions
Is it safe to have Fish Therapy while taking Dextromethorphan HBr, Guaifenesin?
Does Dextromethorphan HBr, Guaifenesin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.