Drug & supplement interaction

Forget-me-not + Letrozole

Letrozole brand name: Femara.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Forget-me-not and Letrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Forget-me-not and Letrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Letrozole and Forget-me-not in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Forget-me-not at all — not against Letrozole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Forget-me-not safety at a glance

Forget-me-not overall Not established There is very little reliable safety or effectiveness data for medicinal use.
Pregnancy Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Letrozole and Forget-me-not? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Forget-me-not Itself Has Been Linked To

This is not an interaction — nothing below involves Letrozole. It is the side-effect record for Forget-me-not on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Forget-me-not, this list is the first place to look.

  • Diarrhea / Vomiting Additional detail

    “Orally, exposure to hepatotoxic pyrrolizidine alkaloids (PA) can cause veno-occlusive disease, lung toxicity, and cancer. Symptoms of acute veno-occlusive disease include colicky pains in epigastrium, vomiting and diarrhea, and ascites formation within several days. Enlargement and induration of the liver occurs within a few weeks.”

    Forget-me-not · Natural Medicines adverse-effect record, reported in cancer.

    1 source cited
    1. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Everything above comes from the Natural Medicines adverse-effect record for Forget-me-not — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Letrozole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Letrozole column appears here.

Special populations

Forget-me-not in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally, due to possible hepatotoxic pyrrolizidine alkaloid content; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Forget-me-not or Letrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Forget-me-not or Letrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Letrozole

This page covers Forget-me-not only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 7-methoxyflavone (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 99 moderate · 40 minor.

From our pharmacist’s overview on the Letrozole page

“Letrozole (Femara) is prescribed to keep hormone-driven breast cancer from returning, so a supplement that shifts its blood level can quietly undercut treatment. Give this list of 142 ingredients genuine respect, and learn the three major entries first.”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole interaction page

How much people look this up

Where Forget-me-not and Letrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Forget-me-not
Steady interest

#934 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole
Top 5%

#50 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Forget-me-not reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Forget-me-not and Letrozole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Forget-me-not

What is Forget-me-not?

  • Respiratory complaints (cough, bronchitis)
  • Nosebleeds and minor bleeding (traditional)
  • Eye complaints (folk use)
  • Skin and wound care (topical, traditional)
  • General tonic in folk medicine

Forget-me-not (Myosotis) is a small flowering plant used in folk medicine, mostly for coughs and minor ailments, but there is very little scientific research to support any health benefit. Because it belongs to a plant family that can contain potentially liver-harming compounds, and because safety data are lacking, it is best used cautiously, if at all, and avoided in pregnancy and breastfeeding.

Myosotis scorpioides · Boraginaceae · Aerial parts (flowers, leaves, and stems) · Tea, tincture, dried herb, occasionally topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Forget-me-not is a good idea for someone in your situation. Here is what our Forget-me-not record says about it on its own.

Forget-me-not: dosing

There is no established or standardized dose for forget-me-not. It has not been studied enough to know a safe and effective amount.If you choose to use a product that contains it, follow the directions on the label and do not exceed them.

From our Forget-me-not monograph — the full record covers uses, side effects and every documented interaction.

Read the full Forget-me-not monograph & all interactions
Medication

About Letrozole

What Is Letrozole Used For?

Brand name: Femara

Letrozole (brand name Femara) is used to treat breast cancer in postmenopausal women whose tumors are driven by estrogen. It is used in three settings: as adjuvant (after-surgery) treatment for hormone receptor positive early breast cancer; as extended adjuvant treatment for women who have already completed about five years of tamoxifen therapy; and as first- or second-line treatment for locally advanced or metastatic (spread) breast cancer.

Femara is specifically indicated for first-line treatment of hormone receptor positive or receptor-unknown locally advanced or metastatic breast cancer, and for advanced breast cancer in women whose disease has progressed after antiestrogen therapy.

See full Letrozole drug information
Keep checking

Other Drugs & Forget-me-not

Browse every other medication we’ve checked against Forget-me-not — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Forget-me-not References

The 1 references that drive our Forget-me-not monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Forget-me-not and Letrozole Together: Common Questions

Is it safe to take Forget-me-not with Letrozole?
We do not list a known interaction between Forget-me-not and Letrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Letrozole interact with any supplements?
Yes. Letrozole has documented interactions with 142 supplements in our database — Forget-me-not is not one of them. The Letrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Letrozole and Forget-me-not?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.