Gamma-oryzanol + Methol/Benzocaine
Methol/Benzocaine brand name: Vicks Formula 44 Sore Throat Lozenges.
We found no known interaction between Gamma-oryzanol and Methol/Benzocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Gamma-oryzanol and Methol/Benzocaine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Methol/Benzocaine and Gamma-oryzanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Gamma-oryzanol at all — not against Methol/Benzocaine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Gamma-oryzanol safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Methol/Benzocaine
This page covers Gamma-oryzanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methol/Benzocaine page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).
By severity: 2 moderate · 1 minor.
From our pharmacist’s overview on the Methol/Benzocaine page
“A sore throat bad enough for Methol/Benzocaine lozenges (Vicks Formula 44) often sends the same person to the supplement aisle, and the good news is that this pairing is manageable for nearly everyone. Just three ingredients have interactions on file, none rated major, and all three affect topical drugs like the numbing benzocaine in t…”
Reviewed by 2 · Jul 18, 2026
Taking Gamma-oryzanol as Part of a Dietary Supplement Product? Check It for Interactions
We hold 272 real supplement products containing Gamma-oryzanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-oryzanol. Even though Gamma-oryzanol itself has no known interaction with Methol/Benzocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Gamma-oryzanol and Methol/Benzocaine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#683 of 1,452 supplements looked up here in the last 7 days
#616 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Gamma-oryzanol and Methol/Benzocaine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Gamma-oryzanol
What is Gamma-oryzanol?
- High cholesterol
- Menopausal symptoms
- Athletic performance and muscle building
- Mild anxiety
- Skin protection (topical)
Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes from small or older studies, so benefits are not well proven. It appears generally well tolerated, but talk with your pharmacist or doctor before using it.
Poaceae · Rice bran oil (derived from Oryza sativa bran) · Capsules, tablets, powder, topical creams
An interaction check asks whether these two react with each other — it does not ask whether Gamma-oryzanol is a good idea for someone in your situation. Here is what our Gamma-oryzanol record says about it on its own.
Gamma-oryzanol: dosing
There is no official or standardized dose for gamma-oryzanol. Doses used in research have varied widely, and what works for one use may not apply to another.The best approach is to follow the directions on the product label and not take more than recommended.
From our Gamma-oryzanol monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Gamma-oryzanol
Browse every other medication we’ve checked against Gamma-oryzanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Gamma-oryzanol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Gamma-oryzanol list.
Sources & How We Checked
We checked Gamma-oryzanol against Methol/Benzocaine in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Gamma-oryzanol and Methol/Benzocaine Together: Common Questions
Is it safe to take Gamma-oryzanol with Methol/Benzocaine?
Does Methol/Benzocaine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Methol/Benzocaine and Gamma-oryzanol?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.