Garden Cress - Adempas (Riociguat) Interaction
Herbal: Garden Cress
Also Known As: Lepidium sativum, Berro Hortelano, Cresson Alénois, Cresson de Jardin, Lepidio, Mastuerzo
Drug: Riociguat
Brand names:
Adempas
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 08, 2025
Interaction Details
Riociguat is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.
Garden cress has shown hypotensive effects in animal research and increases levels and effects of the antihypertensive medications amlodipine and losartan. This has not been shown in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097.
- Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica 2022;52(2):177
- Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33.
Garden Cress Overview
Garden cress (Lepidium sativum) is a fast-growing herb that belongs to the Brassicaceae family. It is native to Europe and Asia and is cultivated for its flavorful, spicy leaves and seeds. Garden cress is often used in salads, sandwiches, and other dishes as a garnish or condiment.
Garden cress is rich in vitamins and minerals, including vitamin C, folic acid, and iron. It is also purported to have various health benefits, including improving digestion, reducing inflammation, and boosting the immune system.
Riociguat Overview
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Riociguat is used to treat pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Riociguat is also used to treat chronic thromboembolic pulmonary hypertension (CTEPH; high blood pressure in the lung arteries caused by blood clots that narrow or block blood flow) in adults who cannot have surgery or for those treated with surgery who continue to have high lung blood pressure levels after surgery. Riociguat may improve the ability to exercise in people with PAH and CTEPH and may slow the worsening of symptoms in people with PAH. Riociguat is in a class of medications called soluble guanylate cyclase (sGC) stimulators. It works by relaxing the blood vessels in the lungs to allow blood to flow easily.
Garden Cress - More Interactions
Garden Cress interacts with 393 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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