Drug & supplement interaction

Globemallow + Methol/Benzocaine

Methol/Benzocaine brand name: Vicks Formula 44 Sore Throat Lozenges.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Globemallow and Methol/Benzocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Globemallow and Methol/Benzocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methol/Benzocaine and Globemallow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Globemallow at all — not against Methol/Benzocaine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Globemallow safety at a glance

Globemallow overall Not established Little modern safety data exists, so use cautiously and under professional guidance.
Pregnancy Avoid There is no reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methol/Benzocaine and Globemallow? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Everything else you take

See Every Supplement That Interacts With Methol/Benzocaine

This page covers Globemallow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methol/Benzocaine page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Methol/Benzocaine page

“A sore throat bad enough for Methol/Benzocaine lozenges (Vicks Formula 44) often sends the same person to the supplement aisle, and the good news is that this pairing is manageable for nearly everyone. Just three ingredients have interactions on file, none rated major, and all three affect topical drugs like the numbing benzocaine in t…”

Reviewed by 2 · Jul 18, 2026

Open the Methol/Benzocaine interaction page

How much people look this up

Where Globemallow and Methol/Benzocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Globemallow
Steady interest

#1,119 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methol/Benzocaine
Top 25%

#442 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Globemallow is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Globemallow reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Globemallow and Methol/Benzocaine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Globemallow

What is Globemallow?

  • Soothing skin irritation
  • Cough and sore throat
  • Digestive upset
  • Minor wounds and inflammation
  • Mouth and throat soothing

Globemallow refers to plants in the genus Sphaeralcea, which have a long history of traditional use among Indigenous peoples of the Americas, mainly as a soothing remedy for skin, throat, and digestive complaints. There is very little modern scientific research on its safety or effectiveness, so its benefits remain unproven. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Sphaeralcea · Malvaceae · Leaves, flowers, roots, and whole aerial parts · Tea, poultice, dried herb, infusion

An interaction check asks whether these two react with each other — it does not ask whether Globemallow is a good idea for someone in your situation. Here is what our Globemallow record says about it on its own.

Globemallow: dosing

There is no established or standardized dose for globemallow. It has not been studied enough to set safe, effective amounts for any use.If you choose to use a globemallow product, follow the directions on the product label and do not exceed them.

From our Globemallow monograph — the full record covers uses, side effects and every documented interaction.

Read the full Globemallow monograph & all interactions
Keep checking

Other Drugs & Globemallow

Browse every other medication we’ve checked against Globemallow — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Globemallow References

The 2 sources that drive our Globemallow monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Globemallow is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbal Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Globemallow and Methol/Benzocaine Together: Common Questions

Is it safe to take Globemallow with Methol/Benzocaine?
We do not list a known interaction between Globemallow and Methol/Benzocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Methol/Benzocaine interact with any supplements?
Yes. Methol/Benzocaine has documented interactions with 3 supplements in our database — Globemallow is not one of them. The Methol/Benzocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Methol/Benzocaine and Globemallow?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.