Drug & supplement interaction

Graviola + Isatuximab-Irfc

Isatuximab-Irfc brand name: Sarclisa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Graviola and Isatuximab-Irfc in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Graviola and Isatuximab-Irfc

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isatuximab-Irfc and Graviola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Graviola safety at a glance

Graviola overall Use caution Human safety data are limited, and lab studies raise concerns about possible nerve toxicity with long-term use.
Pregnancy Possibly Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isatuximab-Irfc and Graviola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Graviola Does Interact With Other Medications

Graviola has 1 moderate known drug interaction in our database — Isatuximab-Irfc isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Isatuximab-Irfc)
Taking anything else?

Check Another of Your Medications Against Graviola

Covers the 2,830 medications we’ve checked against Graviola. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Graviola and Isatuximab-Irfc May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Graviola

    “In one clinical study, some patients reported nausea and burning pain in the epigastrium after taking graviola leaf extract 300 mg daily.”

    Graviola · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 95045. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed

    Isatuximab-Irfc

    Listed in the ADVERSE REACTIONS section of the FDA label for Isatuximab-Irfc. Read the label on DailyMed ›

Effects for Isatuximab-Irfc come from the ADVERSE REACTIONS section of its FDA label; effects for Graviola come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Graviola in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Isatuximab-Irfc Is Prescribed For, and What Graviola Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Isatuximab-Irfc is a prescription medicine with approved uses on its FDA label. Graviola is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Isatuximab-Irfc is prescribed for: Isatuximab-irfc injection is used to treat multiple myeloma (a cancer of plasma cells in the bone marrow) in adult patients. It is always given alongside other medicines — never alone. Sarclisa Escena (the subcutaneous form) is approved in three combinations: with pomalidomide and dexamethasone for patients who have had at least one prior treatment including lenalidomide and a proteasome inhibitor; with carfilzomib and dexamethasone for relapsed or refractory multiple myeloma after one to three prior treatments; and with bortezomib, lenalidomide, and dexamethasone for newly diagnosed multiple myeloma in adults who are not eligible for an autologous stem cell transplant (a procedure using a patient's own stem cells). Intravenous isatuximab-irfc (Sarclisa) is used in the same combinations.

Graviola has been studied for:

  • Cancer studied, not established Graviola has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Graviola for cancer

    Although there has been interest in using oral graviola for cancer, there is insufficient reliable information about the clinical effects of graviola for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Isatuximab-Irfc on your own; if you are taking Graviola for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Graviola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 217 real supplement products containing Graviola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Graviola. Even though Graviola itself has no known interaction with Isatuximab-Irfc, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Graviola and Isatuximab-Irfc Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Graviola
Top half

#534 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isatuximab-Irfc
Steady interest

#2,556 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Graviola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Graviola and Isatuximab-Irfc records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Graviola

What is Graviola?

  • Cancer support (unproven)
  • Infections
  • Inflammation
  • High blood pressure
  • Digestive complaints
  • Diabetes

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online claims that it fights cancer, there is no reliable human evidence that it treats or cures any disease, and animal research raises concerns that it may harm nerve cells. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Annona muricata · Annonaceae · Leaves, fruit, bark, seeds, and roots · Tea, capsules, tinctures, fruit pulp, and juice

An interaction check asks whether these two react with each other — it does not ask whether Graviola is a good idea for someone in your situation. Here is what our Graviola record says about it on its own.

Graviola: dosing

There is no established or standardized safe dose of graviola. Products vary widely in strength and in which plant part they contain.If you choose to use a graviola product, follow the directions on the label, do not exceed the recommended amount, and avoid long-term daily use.

From our Graviola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Graviola monograph & all interactions
Medication

About Isatuximab-irfc Injection

What Is Isatuximab-irfc Injection Used For?

Brand name: Sarclisa

Isatuximab-irfc injection is used to treat multiple myeloma (a cancer of plasma cells in the bone marrow) in adult patients. It is always given alongside other medicines — never alone.

Sarclisa Escena (the subcutaneous form) is approved in three combinations: with pomalidomide and dexamethasone for patients who have had at least one prior treatment including lenalidomide and a proteasome inhibitor; with carfilzomib and dexamethasone for relapsed or refractory multiple myeloma after one to three prior treatments; and with bortezomib, lenalidomide, and dexamethasone for newly diagnosed multiple myeloma in adults who are not eligible for an autologous stem cell transplant (a procedure using a patient's own stem cells). Intravenous isatuximab-irfc (Sarclisa) is used in the same combinations.

See full Isatuximab-irfc Injection drug information
Keep checking

Other Drugs & Graviola

Browse every other medication we’ve checked against Graviola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Graviola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Graviola list.

See the full Graviola interactions page
See every supplement checked against Isatuximab-Irfc, ranked by severity
Evidence & sources

Graviola References

The 4 references that drive our Graviola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Graviola and Isatuximab-Irfc Together: Common Questions

Is it safe to take Graviola with Isatuximab-Irfc?
We do not list a known interaction between Graviola and Isatuximab-Irfc. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Graviola and Isatuximab-Irfc have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Graviola and Isatuximab-Irfc used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Graviola in each. That is a conversation for your prescriber, especially if Isatuximab-Irfc is being adjusted to a target.
Does Graviola interact with any other medications?
Yes. Graviola has 1 documented drug interaction in our database — Isatuximab-Irfc is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Graviola monograph Uses, safety profile, and every drug interaction in one place Isatuximab-irfc Injection drug information The full plain-English guide to this medication Isatuximab-Irfc supplement interactions Every supplement checked against Isatuximab-Irfc, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isatuximab-Irfc and Graviola?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.