Drug & supplement interaction

Graviola + Semaglutide

Semaglutide brand names: Ozempic, Rybelsus, Wegovy.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Graviola and Semaglutide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Graviola and Semaglutide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Semaglutide and Graviola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Graviola safety at a glance

Graviola overall Use caution Human safety data are limited, and lab studies raise concerns about possible nerve toxicity with long-term use.
Pregnancy Possibly Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Semaglutide and Graviola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Semaglutide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Semaglutide is filed under 2 classifications — antidiabetes drugs, oral drugs. Graviola has documented interactions with 1 drug class — the most serious being carbamazepine (tegretol) (moderate) — and none of Semaglutide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Graviola Does Interact With Other Medications

Graviola has 1 moderate known drug interaction in our database — Semaglutide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Semaglutide)
Taking anything else?

Check Another of Your Medications Against Graviola

Covers the 2,830 medications we’ve checked against Graviola. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Graviola and Semaglutide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Graviola

    “In one clinical study, some patients reported nausea and burning pain in the epigastrium after taking graviola leaf extract 300 mg daily.”

    Graviola · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 95045. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed

    Semaglutide

    Listed in the ADVERSE REACTIONS section of the FDA label for Semaglutide. Read the label on DailyMed ›

Effects for Semaglutide come from the ADVERSE REACTIONS section of its FDA label; effects for Graviola come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Graviola in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Semaglutide Is Prescribed For, and What Graviola Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Semaglutide is a prescription medicine with approved uses on its FDA label. Graviola is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Semaglutide is prescribed for: Semaglutide is available as Wegovy (injection and tablet) and Ozempic (injection), and each product has its own approved uses. Wegovy injection is approved — alongside diet and exercise — to reduce excess body weight in adults and in children aged 12 and older with obesity, to lower the risk of serious heart events (heart attack, stroke, or cardiovascular death) in adults with obesity or overweight who also have established heart disease, and for treatment of a liver condition called MASH (metabolic dysfunction-associated steatohepatitis, formerly called NASH) with moderate-to-advanced scarring in adults. Wegovy tablets share the cardiovascular risk reduction and weight management uses in adults, but are not approved for MASH or for use in children. Ozempic injection is approved to improve blood sugar control in adults with type 2 diabetes (alongside diet and exercise) and to reduce the risk of major cardiovascular events in adults with type 2 diabetes who also have established heart disease.

Read the rest of what Semaglutide is prescribed for

All forms are used alongside a reduced-calorie diet and increased physical activity. Ozempic is not approved for type 1 diabetes. The MASH approval for Wegovy injection is an accelerated approval, meaning continued approval may depend on results from a confirmatory study.

Graviola has been studied for:

  • Diabetes studied, not established Graviola has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Graviola for diabetes

    Although there has been interest in using oral graviola for diabetes, there is insufficient reliable information about the clinical effects of graviola for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Semaglutide on your own; if you are taking Graviola for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Graviola or Semaglutide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Graviola or Semaglutide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Semaglutide

This page covers Graviola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Semaglutide page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Semaglutide page

“Semaglutide (Ozempic, Rybelsus, Wegovy) lowers blood sugar, and so do most of the 256 supplements on this page, which is why I read this list with real vigilance rather than a shrug. Nearly all of the entries either add to its glucose-lowering effect and raise the risk of hypoglycemia, or push sugar the other way and blunt it, as niaci…”

Reviewed by 2 · Jul 18, 2026

Open the Semaglutide interaction page

One more smart check

Taking Graviola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 217 real supplement products containing Graviola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Graviola. Even though Graviola itself has no known interaction with Semaglutide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Graviola and Semaglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Graviola
Top half

#447 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Semaglutide
Top 1%

#27 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Graviola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Graviola and Semaglutide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Graviola

What is Graviola?

  • Cancer support (unproven)
  • Infections
  • Inflammation
  • High blood pressure
  • Digestive complaints
  • Diabetes

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online claims that it fights cancer, there is no reliable human evidence that it treats or cures any disease, and animal research raises concerns that it may harm nerve cells. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Annona muricata · Annonaceae · Leaves, fruit, bark, seeds, and roots · Tea, capsules, tinctures, fruit pulp, and juice

An interaction check asks whether these two react with each other — it does not ask whether Graviola is a good idea for someone in your situation. Here is what our Graviola record says about it on its own.

Graviola: dosing

There is no established or standardized safe dose of graviola. Products vary widely in strength and in which plant part they contain.If you choose to use a graviola product, follow the directions on the label, do not exceed the recommended amount, and avoid long-term daily use.

From our Graviola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Graviola monograph & all interactions
Medication

About Semaglutide

What Is Semaglutide Used For?

Brand names: Ozempic, Rybelsus, Wegovy

Semaglutide is available as Wegovy (injection and tablet) and Ozempic (injection), and each product has its own approved uses. Wegovy injection is approved — alongside diet and exercise — to reduce excess body weight in adults and in children aged 12 and older with obesity, to lower the risk of serious heart events (heart attack, stroke, or cardiovascular death) in adults with obesity or overweight who also have established heart disease, and for treatment of a liver condition called MASH (metabolic dysfunction-associated steatohepatitis, formerly called NASH) with moderate-to-advanced scarring in adults. Wegovy tablets share the cardiovascular risk reduction and weight management uses in adults, but are not approved for MASH or for use in children. Ozempic injection is approved to improve blood sugar control in adults with type 2 diabetes (alongside diet and exercise) and to reduce the risk of major cardiovascular events in adults with type 2 diabetes who also have established heart disease.

All forms are used alongside a reduced-calorie diet and increased physical activity. Ozempic is not approved for type 1 diabetes. The MASH approval for Wegovy injection is an accelerated approval, meaning continued approval may depend on results from a confirmatory study.

See full Semaglutide drug information
Keep checking

Other Drugs & Graviola

Browse every other medication we’ve checked against Graviola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Graviola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Graviola list.

See the full Graviola interactions page
See every supplement checked against Semaglutide, ranked by severity
Evidence & sources

Graviola References

The 4 references that drive our Graviola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Graviola and Semaglutide Together: Common Questions

Is it safe to take Graviola with Semaglutide?
We do not list a known interaction between Graviola and Semaglutide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Graviola and Semaglutide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Graviola and Semaglutide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Graviola in each. That is a conversation for your prescriber, especially if Semaglutide is being adjusted to a target.
How was the Graviola and Semaglutide combination checked?
Interactions in our licensed database are recorded against drug classes. Semaglutide is filed under 2 classifications, and Graviola has documented interactions with 1 drug class — none of Semaglutide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Graviola interact with any other medications?
Yes. Graviola has 1 documented drug interaction in our database — Semaglutide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Semaglutide interact with any supplements?
Yes. Semaglutide has documented interactions with 256 supplements in our database — Graviola is not one of them. The Semaglutide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Graviola monograph Uses, safety profile, and every drug interaction in one place Semaglutide drug information The full plain-English guide to this medication Semaglutide supplement interactions Every supplement checked against Semaglutide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Semaglutide and Graviola?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.