Medication interaction hub

What Supplements Interact with Semaglutide?

Semaglutide brand names: Ozempic, Rybelsus, Wegovy. Every interaction below applies to the brands too.

256 Interactions 2 Major 215 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Semaglutide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Semaglutide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Semaglutide (Ozempic, Rybelsus, Wegovy) lowers blood sugar, and so do most of the 256 supplements on this page, which is why I read this list with real vigilance rather than a shrug. Nearly all of the entries either add to its glucose-lowering effect and raise the risk of hypoglycemia, or push sugar the other way and blunt it, as niacin does. Two are rated major: Siberian cocklebur has caused severe, worsening low blood sugar in people, and activated charcoal can soak up oral medicines before they absorb.

The charcoal problem matters most with Rybelsus, the tablet form, and it is not alone. Seventeen entries can change how oral drugs are absorbed, so space those well apart from a Rybelsus dose. The other 215 moderate and 39 minor entries are mostly the same additive blood sugar effects, worth sorting out before you add one, not after low blood sugar makes the point.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 215 Minor 39 No known interaction 1,196

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Semaglutide: Top Interactions at a Glance

The Semaglutide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Semaglutide Combinations Today

The Semaglutide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Oregano + Semaglutidei

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Milk Thistle + Semaglutidei

Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Clove + Semaglutidei

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Dandelion + Semaglutidei

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.

Read the full interaction Minor Likelihood Possible Apple Cider Vinegar + Semaglutidei

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Semaglutidei

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Semaglutide

All 1,452 ingredients in our database, ranked by severity — 256 with a Semaglutide interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Semaglutide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Oregano with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.

Full Oregano + Semaglutide answer

Can you take Milk Thistle with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Semaglutide answer

Can you take Clove with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Full Clove + Semaglutide answer

Can you take Dandelion with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.

Full Dandelion + Semaglutide answer

Can you take Apple Cider Vinegar with Semaglutide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Semaglutide answer

Can you take Terminalia Bellirica with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Semaglutide answer

Can you take Terminalia Chebula with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Semaglutide answer

Can you take Theaflavin with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.

Full Theaflavin + Semaglutide answer

Can you take Tinospora Cordifolia with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Tinospora Cordifolia + Semaglutide answer

Can you take Tiratricol with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Semaglutide answer

Can you take Tragacanth with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Semaglutide answer

Can you take Tribulus with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Tribulus + Semaglutide answer

Can you take Tronadora with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Full Tronadora + Semaglutide answer

Can you take Turkey Tail Mushroom with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Semaglutide answer

Can you take Turmeric with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turmeric + Semaglutide answer

Can you take Weight Watchers Diet with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.

Full Weight Watchers Diet + Semaglutide answer

Can you take Wheatgrass with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Full Wheatgrass + Semaglutide answer

Can you take White Horehound with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.

Full White Horehound + Semaglutide answer

Can you take White Mulberry with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Semaglutide answer

Can you take White Pepper with Semaglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that piperine, a constituent of white pepper, reduces blood glucose levels.

Full White Pepper + Semaglutide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Semaglutide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Semaglutide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Semaglutide sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Semaglutide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Semaglutide through this category.

About Semaglutide

Semaglutide is an incretin mimetic medication used to help control blood sugar levels in adults with type 2 diabetes.

Generic name: Semaglutide  ·  Brand names: Ozempic, Rybelsus, Wegovy.

See the full Semaglutide drug information

Related: does Semaglutide deplete any nutrients?

Semaglutide has 2 reported nutrient associations in the research literature — see the Semaglutide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Semaglutide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Semaglutide.

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Pharmacist Counseling Corner

Semaglutide & Supplements: Common Questions

What supplements interact with Semaglutide?
In our interaction database, 256 supplement and herbal ingredients have an interaction with Semaglutide on file — 2 rated major, 215 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Semaglutide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Semaglutide?
That depends entirely on which supplement. The honest answer for Semaglutide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Ozempic have the same supplement interactions as Semaglutide?
Yes — Ozempic, Rybelsus, Wegovy all contain Semaglutide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Semaglutide deplete any vitamins or nutrients?
It might — Semaglutide has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Semaglutide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Semaglutide and my other medications?
This page covers Semaglutide against supplements and herbal ingredients. Checking Semaglutide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Semaglutide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.