Semaglutide

36 interactions 1 explained in plain English

Also sold as: Ozempic Reybelsus® Rybelsus Wegovy

About Semaglutide

Semaglutide is an incretin mimetic medication used to help control blood sugar levels in adults with type 2 diabetes. Read the full Semaglutide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Glipizide Levofloxacin Injection Chloroquine Moxifloxacin Ofloxacin Otic Insulin Glulisine (Rdna Origin) Injection

23 Major 13 Moderate

All (36) Major (23) Moderate (13)

Major

Semaglutide Atogepant Qulipta Increased atogepant exposure Details Semaglutide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Semaglutide Chloroquine Aralen® Hypoglycemia Details Semaglutide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Glimepiride Amaryl An increased risk of hypoglycemia Details Semaglutide Glipizide Glucotrol An increased risk of hypoglycemia Details Semaglutide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Semaglutide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Semaglutide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Semaglutide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Semaglutide Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Lithium Carbonate Lithobid Increased lithium exposure Details Semaglutide Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Nateglinide Starlix® An increased risk of hypoglycemia Details Semaglutide Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Semaglutide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Semaglutide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Semaglutide Alectinib Alecensa Decreased alectinib exposure Details Semaglutide Benazepril Lotensin An increased risk of hypoglycemia Details Semaglutide Captopril Capoten® An increased risk of hypoglycemia Details Semaglutide Dulaglutide Injection Trulicity Increased risk of semaglutide-related adverse effects Details Semaglutide Enalapril Epaned An increased risk of hypoglycemia Details Semaglutide Exenatide Injection Bydureon Increased risk of semaglutide-related adverse effects Details Semaglutide Fosinopril Monopril® An increased risk of hypoglycemia Details Semaglutide Levothyroxine Ermeza Increased levothyroxine exposure, decreased TSH and worsening of glycemic control Details Semaglutide Liraglutide Injection Saxenda Increased risk of semaglutide-related adverse effects Details Semaglutide Lixisenatide Injection Adlyxin® Increased risk of semaglutide-related adverse effects Details Semaglutide Moexipril Univasc® An increased risk of hypoglycemia Details Semaglutide Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.