Drug & supplement interaction

Mastic + Semaglutide

Semaglutide brand names: Ozempic, Rybelsus, Wegovy.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mastic and Semaglutide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mastic and Semaglutide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Semaglutide and Mastic in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mastic at all — not against Semaglutide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mastic safety at a glance

Mastic overall Use caution Generally well tolerated in food and traditional amounts, but supplement-strength data are limited.
Pregnancy Avoid Not enough safety information; best to avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Semaglutide and Mastic? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mastic and Semaglutide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation / Diarrhea / Nausea Additional detail

    Mastic

    “Orally, nausea, diarrhea, and constipation have been rarely reported following use of mastic gum. In one case, constipation ceased two days after discontinuing mastic gum.”

    Mastic · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 62051. Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753. PubMed
    2. 62069. Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. PubMed
    3. 62071. Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-20 PubMed

    Semaglutide

    Listed in the ADVERSE REACTIONS section of the FDA label for Semaglutide. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Mastic

    “Subcutaneously, administration of a specific mastic extract (RPh201, Regenera Pharma) has been reported to cause headache and dizziness.”

    Mastic · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 103266. Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74. PubMed

    Semaglutide

    Listed in the ADVERSE REACTIONS section of the FDA label for Semaglutide. Read the label on DailyMed ›

Reported for Mastic but not commonly for Semaglutide: a skin rash, bleeding or bruising and itching.

Effects for Semaglutide come from the ADVERSE REACTIONS section of its FDA label; effects for Mastic come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Mastic or Semaglutide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mastic or Semaglutide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Semaglutide

This page covers Mastic only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Semaglutide page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Semaglutide page

“Semaglutide (Ozempic, Rybelsus, Wegovy) lowers blood sugar, and so do most of the 256 supplements on this page, which is why I read this list with real vigilance rather than a shrug. Nearly all of the entries either add to its glucose-lowering effect and raise the risk of hypoglycemia, or push sugar the other way and blunt it, as niaci…”

Reviewed by 2 · Jul 18, 2026

Open the Semaglutide interaction page

One more smart check

Taking Mastic as Part of a Dietary Supplement Product? Check It for Interactions

We hold 104 real supplement products containing Mastic, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mastic. Even though Mastic itself has no known interaction with Semaglutide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mastic and Semaglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mastic
Top half

#458 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Semaglutide
Top 1%

#24 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mastic reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mastic and Semaglutide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mastic

What is Mastic?

Mastic
  • Indigestion and stomach upset
  • Stomach ulcers and H. pylori support
  • Oral and gum health
  • Bad breath
  • General antioxidant/anti-inflammatory support

Mastic is a resin from the mastic tree that has a long history of use for digestive complaints and oral health. Some small studies suggest it may help with indigestion, stomach ulcers, and dental hygiene, but the evidence is limited and not conclusive. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before using it as a supplement, especially if you are pregnant or breastfeeding.

Pistacia lentiscus · Anacardiaceae · Resin (gum) from the tree; sometimes the essential oil · Capsules, chewable gum/resin tears, powder, essential oil, mouthwash, toothpaste

An interaction check asks whether these two react with each other — it does not ask whether Mastic is a good idea for someone in your situation. Here is what our Mastic record says about it on its own.

Mastic: dosing

There is no official or standardized dose of mastic. Studies have used different forms and amounts, so it is hard to recommend one exact dose. The strength of capsules, powders, and chewing products can vary a lot between brands.The safest approach is to follow the directions on the product label and not exceed the suggested amount. Because supplements are not tightly regulated, choose a reputable brand when possible.

From our Mastic monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mastic monograph & all interactions
Medication

About Semaglutide

What Is Semaglutide Used For?

Brand names: Ozempic, Rybelsus, Wegovy

Semaglutide is available as Wegovy (injection and tablet) and Ozempic (injection), and each product has its own approved uses. Wegovy injection is approved — alongside diet and exercise — to reduce excess body weight in adults and in children aged 12 and older with obesity, to lower the risk of serious heart events (heart attack, stroke, or cardiovascular death) in adults with obesity or overweight who also have established heart disease, and for treatment of a liver condition called MASH (metabolic dysfunction-associated steatohepatitis, formerly called NASH) with moderate-to-advanced scarring in adults. Wegovy tablets share the cardiovascular risk reduction and weight management uses in adults, but are not approved for MASH or for use in children. Ozempic injection is approved to improve blood sugar control in adults with type 2 diabetes (alongside diet and exercise) and to reduce the risk of major cardiovascular events in adults with type 2 diabetes who also have established heart disease.

All forms are used alongside a reduced-calorie diet and increased physical activity. Ozempic is not approved for type 1 diabetes. The MASH approval for Wegovy injection is an accelerated approval, meaning continued approval may depend on results from a confirmatory study.

See full Semaglutide drug information
Keep checking

Other Drugs & Mastic

Browse every other medication we’ve checked against Mastic — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mastic against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mastic list.

See the full Mastic interactions page
See every supplement checked against Semaglutide, ranked by severity
Evidence & sources

Mastic References

The 5 references that drive our Mastic monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753. PubMed
  2. Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. PubMed
  3. Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-20 PubMed
  4. Hazan Z, Adamsky K, Lucassen A, Levin LA. A first-in-human phase 1 randomized single and multiple ascending dose study of RPh201 in healthy volunteers. Clin Pharmacol Drug Dev. 2020;9(3):366-74. PubMed
  5. Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 2020;24(6):1877-1888. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mastic and Semaglutide Together: Common Questions

Is it safe to take Mastic with Semaglutide?
We do not list a known interaction between Mastic and Semaglutide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mastic and Semaglutide have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Semaglutide interact with any supplements?
Yes. Semaglutide has documented interactions with 256 supplements in our database — Mastic is not one of them. The Semaglutide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mastic monograph Uses, safety profile, and every drug interaction in one place Semaglutide drug information The full plain-English guide to this medication Semaglutide supplement interactions Every supplement checked against Semaglutide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Semaglutide and Mastic?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.