Castor Bean + Semaglutide
Semaglutide brand names: Ozempic, Rybelsus, Wegovy.
We found no known interaction between Castor Bean and Semaglutide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Castor Bean and Semaglutide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Semaglutide and Castor Bean in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Castor Bean safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Semaglutide
Interactions in our licensed database are recorded against drug classes, not just single drug names. Semaglutide is filed under 2 classifications — antidiabetes drugs, oral drugs. Castor Bean has documented interactions with 1 drug class — the most serious being diuretic drugs (moderate) — and none of Semaglutide’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Castor Bean Does Interact With Other Medications
Castor Bean has 75 moderate known drug interactions in our database — Semaglutide isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Castor Bean
We haven’t checked that one against Castor Bean yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Castor Bean. Pick one to open its full report.
Castor Bean in Pregnancy & Breastfeeding
When castor oil is used orally in pregnant women at term. Although there have been reports of fetal meconium passage being more common with castor oil use in pregnant women, clinical research shows that the incidence of fetal meconium passage does not significantly differ from no castor oil use. Midwives routinely use castor oil for labor induction in pregnant women at term. This practice does not appear to adversely affect the mother or fetus. However, castor oil should not be used without the supervision of a clinician.
When castor oil is used orally in pregnant women who are not at term. Castor oil might induce premature labor and induce miscarriage; avoid using.
When the whole seed is used orally. The chewed or uncoated seeds can cause severe toxic effects, including death; avoid using. There is insufficient reliable information available about the safety of using the hulled seed or topical use of castor during pregnancy.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Castor Bean or Semaglutide
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Castor Bean or Semaglutide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Divide an Ozempic 8mg Pen to Take 0.25mg Doses? ›
- Can You Dose 0.25mg Of Ozempic With The 2mg Pen? ›
- Is Inositol Safe With Ozempic (Semaglutide)? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Semaglutide
This page covers Castor Bean only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Semaglutide page lists 256 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).
By severity: 2 major · 215 moderate · 39 minor.
From our pharmacist’s overview on the Semaglutide page
“Semaglutide (Ozempic, Rybelsus, Wegovy) lowers blood sugar, and so do most of the 256 supplements on this page, which is why I read this list with real vigilance rather than a shrug. Nearly all of the entries either add to its glucose-lowering effect and raise the risk of hypoglycemia, or push sugar the other way and blunt it, as niaci…”
Reviewed by 2 · Jul 18, 2026
Where Castor Bean and Semaglutide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,452 of 1,452 supplements looked up here in the last 7 days
#24 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Castor Bean reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Castor Bean and Semaglutide records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Castor Bean
What is Castor Bean?
- Constipation relief
- Skin and hair care
- Labor induction (folk use)
- Topical anti-inflammatory packs
- Joint and muscle massage
Castor bean is the source of castor oil, a well-known stimulant laxative, but the raw seeds contain ricin, a potent and potentially deadly poison. The processed oil is generally considered safe when used as directed, while the whole or chewed seeds should never be eaten. Always talk to a pharmacist or doctor before using castor oil, especially during pregnancy or for children.
Ricinus communis · Euphorbiaceae · Seeds (beans) and the oil pressed from them · Castor oil (liquid), capsules, topical oils, and packs
An interaction check asks whether these two react with each other — it does not ask whether Castor Bean is a good idea for someone in your situation. Here is what our Castor Bean record says about it on its own.
Castor Bean: dosing
There is no single standard dose for all uses. For constipation, castor oil is sold as an over-the-counter laxative, and you should follow the directions on the product label or your pharmacist's advice. It is meant for short-term, occasional use only.Do not use higher amounts hoping for a stronger effect, and do not use it daily without medical guidance.
From our Castor Bean monograph — the full record covers uses, side effects and every documented interaction.
About Semaglutide
What Is Semaglutide Used For?
Brand names: Ozempic, Rybelsus, Wegovy
Semaglutide is available as Wegovy (injection and tablet) and Ozempic (injection), and each product has its own approved uses. Wegovy injection is approved — alongside diet and exercise — to reduce excess body weight in adults and in children aged 12 and older with obesity, to lower the risk of serious heart events (heart attack, stroke, or cardiovascular death) in adults with obesity or overweight who also have established heart disease, and for treatment of a liver condition called MASH (metabolic dysfunction-associated steatohepatitis, formerly called NASH) with moderate-to-advanced scarring in adults. Wegovy tablets share the cardiovascular risk reduction and weight management uses in adults, but are not approved for MASH or for use in children. Ozempic injection is approved to improve blood sugar control in adults with type 2 diabetes (alongside diet and exercise) and to reduce the risk of major cardiovascular events in adults with type 2 diabetes who also have established heart disease.
All forms are used alongside a reduced-calorie diet and increased physical activity. Ozempic is not approved for type 1 diabetes. The MASH approval for Wegovy injection is an accelerated approval, meaning continued approval may depend on results from a confirmatory study.
Other Drugs & Castor Bean
Browse every other medication we’ve checked against Castor Bean — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
75 interactions
- Hydrochlorothiazide ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Metolazone ›
- Spironolactone ›
- Acetazolamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Indapamide ›
- Mannitol ›
- Methyclothiazide ›
- Torsemide ›
- Ammonium Chloride ›
- Benzthiazide ›
- Bumetanide ›
- Chlorothiazide ›
- Ethacrynic Acid ›
- Furosemide ›
- Hydroflumethiazide ›
- Methazolamide ›
- Polythiazide ›
- Quinethazone ›
- Theobromine ›
- Urea ›
- Hydrochlorothiazide, Triamterene ›
- Amiloride, Hydrochlorothiazide ›
- Hydrochlorothiazide, Methyldopa ›
- Hydrochlorothiazide, Reserpine ›
- Hydrochlorothiazide, Spironolactone ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Atenolol, Chlortalidone ›
- Chlorothiazide, Methyldopa ›
- Hydralazine, Hydrochlorothiazide, Reserpine ›
- Reserpine, Trichlormethiazide ›
- Bendroflumethiazide, Potassium ›
- Captopril, Hydrochlorothiazide ›
- Chlorthalidone, Clonidine ›
- Deserpidine, Hydrochlorothiazide ›
- Deserpidine, Methyclothiazide ›
- Furosemide, Potassium ›
- Hydralazine, Hydrochlorothiazide ›
- Hydrochlorothiazide, Lisinopril ›
- Hydroflumethiazide, Reserpine ›
- Acetaminophen, Caffeine, Pyrilamine ›
- Atenolol, Chlorthalidone ›
- Azilsartan, Chlorthalidone ›
- Benazepril, Hydrochlorothiazide ›
- Bendroflumethiazide, Nadolol ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Bisoprolol, Hydrochlorothiazide ›
- Bumetanide, Potassium ›
- Caffeine, Potassium Salicylate, Salicylamide ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Chlorothiazide, Reserpine ›
- Cryptenamine, Methyclothiazide ›
- Enalapril Maleate, Hydrochlorothiazide ›
- Fosinopril, Hydrochlorothiazide ›
- Guanethidine, Hydrochlorothiazide ›
- Hydrochlorothiazide, Irbesartan ›
- Hydrochlorothiazide, Labetalol ›
Showing 60 of 75 moderate interactions — see all 75 on the Castor Bean page.
No interaction 2,754 drugs checked — show the list
We also checked Castor Bean against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,754 medications checked with no known interaction — see the full Castor Bean list.
Castor Bean References
The 25 references that drive our Castor Bean monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16. PubMed
- Steingrub JS, Lopez T, Teres D, et al. Amniotic fluid embolism associated with castor oil ingestion. Crit Care Med 1988;16:642-3. PubMed
- Challoner KR, McCarron MM. Castor bean intoxication. Ann Emerg Med 1990;19:1177-83. PubMed
- Palatnick W, Tenenbein M. Hepatotoxicity from castor bean ingestion in a child. J Toxicol Clin Toxicol 2000;38:67-9. PubMed
- Isichei CO, Das SC, Ogunkeye OO, et al. Preliminary clinical investigation of the contraceptive efficacy and chemical pathological effects of RICOM-1013-J of Ricinus communis var minor on women volunteers. Phytother Res 2000;14:40-2.
- Garry D, Figueroa R, Guillaume J, Cucco V. Use of castor oil in pregnancies at term. Altern Ther Health Med 2000;6:77-9.
- Audi J, Belson M, Patel M, et al. Ricin poisoning: a comprehensive review. JAMA 2005;294:2342-51.
- Chen, C. C., Ng, W. W., Chang, F. Y., and Lee, S. D. Magnesium citrate-bisacodyl regimen proves better than castor oil for colonoscopic preparation. J.Gastroenterol.Hepatol. 1999;14(12):1219-1222. PubMed
- Azhari, S., Pirdadeh, S., Lotfalizadeh, M., and Shakeri, M. T. Evaluation of the effect of castor oil on initiating labor in term pregnancy. Saudi.Med J 2006;27(7):1011-1014. DOI
- Kris, M. G., Gralla, R. J., Clark, R. A., Tyson, L. B., and Groshen, S. Control of chemotherapy-induced diarrhea with the synthetic enkephalin BW942C: a randomized trial with placebo in patients receiving cisplatin. J Clin.Oncol. 1988;6(4):663-668. PubMed
- Mitri, F., Hofmeyr, G. J., and van Gelderen, C. J. Meconium during labour--self-medication and other associations. S.Afr.Med J 4-4-1987;71(7):431-433.
- Strates, B. S. and Hofmann, L. M. A randomized study of two preparations for large bowel radiology. Pharmatherapeutica 1987;5(1):57-61.
- Ryan, J., Leighton, J., Kirksey, D., and McMahon, G. Evaluation of an enkephalin analog in men with castor oil-induced diarrhea. Clin.Pharmacol.Ther. 1986;39(1):40-42. PubMed
- Dodds, W. J., Scanlon, G. T., Shaw, D. K., Stewart, E. T., Youker, J. E., and Metter, G. E. An evaluation of colon cleansing regimens. AJR Am.J Roentgenol. 1977;128(1):57-59. PubMed
- Present, A. J., Jansson, B., Burhenne, H. J., Dodd, G. D., Goldberg, H. I., Goldstein, H. M., Miller, R. E., Nelson, J. A., and Stewart, E. T. Evaluation of 12 colon-cleansing regimens with single-contrast barium enema. AJR Am.J Roentgenol. 1982;139(5):8 PubMed
- Kolts, B. E., Lyles, W. E., Achem, S. R., Burton, L., Geller, A. J., and MacMath, T. A comparison of the effectiveness and patient tolerance of oral sodium phosphate, castor oil, and standard electrolyte lavage for colonoscopy or sigmoidoscopy preparatio
- Ferguson TS. Castor bean ingestion and ricin toxicity in a case of attempted suicide. West Indian Med J 2011;60(5):596.
- Kamath JV, Rana AC, Chowdhury AR. Pro-healing effect of Cinnamomum zeylanicum bark. Phytother Res 2003;17(8):970-2.
- Thornton SL, Darracq M, Lo J, et al. Castor bean seed ingestions: a state-wide poison control system's experience. Clin Toxicol (Phila) 2014;52(4):265-8. PubMed
- Worbs S, Köhler K, Pauly D, et al. Ricinus communis intoxications in human and veterinary medicine-a summary of real cases. Toxins (Basel) 2011;3(10):1332-72. PubMed
- Verougstraete N, Helsloot D, Deprez C, Heylen O, Casier I, Croes K. Lethal Injection of a Castor Bean Extract: Ricinine Quantification as a Marker for Ricin Exposure Using a Validated LC-MS/MS Method. J Anal Toxicol. 2019;43(3):e1-e5. PubMed
- Sánchez-Herrero A, Mateos-Mayo A, Rodríguez-Lomba E, et al. Allergic contact cheilitis in an adolescent to Ricinus communis seed oil (castor oil) in a lip balm. Contact Dermatitis. 2018;79(3):176-178.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Semaglutide Is Linked to Lower Levels of One Nutrient
Natural Medicines records Semaglutide as a medicine that can lower these. This is not an interaction with Castor Bean — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Semaglutide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Castor Bean and Semaglutide Together: Common Questions
Is it safe to take Castor Bean with Semaglutide?
Do Castor Bean and Semaglutide have any of the same side effects?
How was the Castor Bean and Semaglutide combination checked?
Does Castor Bean interact with any other medications?
Does Semaglutide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Semaglutide and Castor Bean?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.