Drug & supplement interaction

Akkermansia + Semaglutide

Semaglutide brand names: Ozempic, Rybelsus, Wegovy.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Akkermansia and Semaglutide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Akkermansia and Semaglutide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Semaglutide and Akkermansia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Akkermansia at all — not against Semaglutide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Akkermansia safety at a glance

Akkermansia overall Use caution Small human studies suggest short-term use is generally well tolerated, but long-term safety data are limited.
Pregnancy Avoid There is not enough safety information, so it is best to avoid during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Semaglutide and Akkermansia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Semaglutide’s Own FDA Label Lists

This is not an interaction — none of it involves Akkermansia. These are the most notable effects listed in the ADVERSE REACTIONS section of Semaglutide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • Pancreatitis Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • An allergic reaction Worth acting on
  • Heartburn
  • Bloating or gas
  • Hair loss
  • Drowsiness
  • Stomach upset

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Semaglutide. Read the label on DailyMed › Akkermansia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Akkermansia side to compare — that is a limit of the record, not a statement that Akkermansia has no side effects.

From our Q&A

Questions About Akkermansia or Semaglutide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Akkermansia or Semaglutide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Semaglutide

This page covers Akkermansia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Semaglutide page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Semaglutide page

“Semaglutide (Ozempic, Rybelsus, Wegovy) lowers blood sugar, and so do most of the 256 supplements on this page, which is why I read this list with real vigilance rather than a shrug. Nearly all of the entries either add to its glucose-lowering effect and raise the risk of hypoglycemia, or push sugar the other way and blunt it, as niaci…”

Reviewed by 2 · Jul 18, 2026

Open the Semaglutide interaction page

How much people look this up

Where Akkermansia and Semaglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Akkermansia
Steady interest

#914 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Semaglutide
Top 5%

#33 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Akkermansia is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Akkermansia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Akkermansia and Semaglutide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Akkermansia

What is Akkermansia?

  • Gut health support
  • Metabolic health and blood sugar
  • Weight management
  • Gut lining (barrier) support

Akkermansia muciniphila is a gut bacterium sold as a next-generation probiotic. Early research in animals and small human studies looks promising for metabolic and gut health, but the evidence is still limited and long-term safety is not fully known. Talk with your pharmacist or doctor before trying it, especially if you have a weakened immune system.

Akkermansia muciniphila · Akkermansiaceae · Whole bacterial cells (live or pasteurized) · Capsules, powders (probiotic supplements)

An interaction check asks whether these two react with each other — it does not ask whether Akkermansia is a good idea for someone in your situation. Here is what our Akkermansia record says about it on its own.

Akkermansia: dosing

There is no official, standardized dose for Akkermansia muciniphila. Doses are usually measured in colony-forming units (CFU) or by the amount of bacterial cells, and these vary from product to product.The best approach is to follow the directions on the product label and not take more than recommended. If you notice ongoing digestive problems, stop and get medical advice.

From our Akkermansia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Akkermansia monograph & all interactions
Medication

About Semaglutide

What Is Semaglutide Used For?

Brand names: Ozempic, Rybelsus, Wegovy

Semaglutide is used for several conditions, depending on the product. Wegovy is used with a reduced-calorie diet and more physical activity to reduce excess body weight and keep it off long term. It is also used to lower the risk of major cardiovascular events (heart-related death, non-fatal heart attack, or non-fatal stroke) in adults with established cardiovascular disease and either obesity or overweight.

Wegovy injection is also used for adults with noncirrhotic MASH (a fatty liver disease) with moderate to advanced liver scarring, and for weight management in children 12 and older with obesity. Ozempic is an injection used with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It also lowers the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Ozempic is not for type 1 diabetes.

See full Semaglutide drug information
Keep checking

Other Drugs & Akkermansia

Browse every other medication we’ve checked against Akkermansia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Akkermansia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Akkermansia list.

See the full Akkermansia interactions page
See every supplement checked against Semaglutide, ranked by severity
Evidence & sources

Akkermansia References

The 2 sources that drive our Akkermansia monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Akkermansia is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Probiotics: What You Need To Know — NIH NCCIH Source
  2. Probiotics — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Akkermansia and Semaglutide Together: Common Questions

Is it safe to take Akkermansia with Semaglutide?
We do not list a known interaction between Akkermansia and Semaglutide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Semaglutide interact with any supplements?
Yes. Semaglutide has documented interactions with 256 supplements in our database — Akkermansia is not one of them. The Semaglutide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Akkermansia monograph Uses, safety profile, and every drug interaction in one place Semaglutide drug information The full plain-English guide to this medication Semaglutide supplement interactions Every supplement checked against Semaglutide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Semaglutide and Akkermansia?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.