Great Plantain + Tasimelteon
Tasimelteon brand names: Hetlioz, Hetlioz Lq.
We found no known interaction between Great Plantain and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.
Great Plantain and Tasimelteon
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tasimelteon and Great Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Great Plantain safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tasimelteon
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tasimelteon is filed under 5 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, cns depressants. Great Plantain has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Tasimelteon’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Great Plantain Does Interact With Other Medications
Great Plantain has 2 moderate known drug interactions in our database — Tasimelteon isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Great Plantain
We haven’t checked that one against Great Plantain yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Great Plantain. Pick one to open its full report.
Great Plantain in Pregnancy & Breastfeeding
When used orally because it can increase uterine tone.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Tasimelteon Products Have a Food Rule — Great Plantain Should Not Break It
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Great Plantain included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Great Plantain to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti
From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. See the Tasimelteon drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tasimelteon
This page covers Great Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).
By severity: 9 major · 166 moderate · 43 minor.
From our pharmacist’s overview on the Tasimelteon page
“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”
Reviewed by 2 · Jul 18, 2026
Where Great Plantain and Tasimelteon Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,092 of 1,452 supplements looked up here in the last 7 days
#1,724 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Great Plantain reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Great Plantain and Tasimelteon records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Great Plantain
What is Great Plantain?
- Minor wounds and skin irritation
- Insect bites and stings
- Coughs and sore throat
- Digestive upset
- Mild inflammation
Great Plantain is a common weed traditionally used on the skin for minor wounds and bites, and as a tea for coughs or stomach upset. Human evidence for most of these uses is limited, though the plant appears generally well tolerated. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.
Plantago major · Plantaginaceae · Leaves and seeds · Tea, capsules, tinctures, topical salves and ointments, fresh crushed leaves (poultice)
An interaction check asks whether these two react with each other — it does not ask whether Great Plantain is a good idea for someone in your situation. Here is what our Great Plantain record says about it on its own.
Great Plantain: dosing
There is no well-established standardized dose for Great Plantain. Traditional use varies widely, and the amount of active compounds differs between products and plant sources.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you and review your other medications and health conditions first.
From our Great Plantain monograph — the full record covers uses, side effects and every documented interaction.
About Tasimelteon
What Is Tasimelteon Used For?
Brand names: Hetlioz, Hetlioz Lq
Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.
Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.
Most-Reported Side Effects for Tasimelteon
From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Great Plantain
Browse every other medication we’ve checked against Great Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Great Plantain against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Great Plantain list.
Great Plantain References
The 3 references that drive our Great Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Great Plantain and Tasimelteon Together: Common Questions
Is it safe to take Great Plantain with Tasimelteon?
Should I take Great Plantain and Tasimelteon at the same time of day?
How was the Great Plantain and Tasimelteon combination checked?
Does Great Plantain interact with any other medications?
Does Tasimelteon interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Tasimelteon and Great Plantain?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.