Great Plantain + Vedolizumab
Vedolizumab brand name: Entyvio.
We found no known interaction between Great Plantain and Vedolizumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Great Plantain and Vedolizumab
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Vedolizumab and Great Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Great Plantain safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Vedolizumab
Interactions in our licensed database are recorded against drug classes, not just single drug names. Vedolizumab is filed under a single classification — hepatotoxic drugs. Great Plantain has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Vedolizumab’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Great Plantain Does Interact With Other Medications
Great Plantain has 2 moderate known drug interactions in our database — Vedolizumab isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Great Plantain
We haven’t checked that one against Great Plantain yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Great Plantain. Pick one to open its full report.
Great Plantain in Pregnancy & Breastfeeding
When used orally because it can increase uterine tone.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Vedolizumab Is Prescribed For, and What Great Plantain Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Vedolizumab is a prescription medicine with approved uses on its FDA label. Great Plantain is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Vedolizumab is prescribed for: Vedolizumab Injection (sold as Entyvio) treats adults with moderately to severely active ulcerative colitis and moderately to severely active Crohn's disease. Both are long-term inflammatory conditions of the digestive tract. It is given by vein (intravenous) and, after the first two infusions, can also be given as an injection under the skin (subcutaneous), including with the ENTYVIO Pen.
Great Plantain has been studied for:
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Ulcerative colitis studied, not established Great Plantain has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Great Plantain for ulcerative colitis
It is unclear if oral great plantain seed is beneficial in patients with ulcerative colitis.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Vedolizumab on your own; if you are taking Great Plantain for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Vedolizumab
This page covers Great Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vedolizumab page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).
By severity: 3 major · 35 moderate.
From our pharmacist’s overview on the Vedolizumab page
“Every entry on this page points at the same organ, the liver. Vedolizumab (Entyvio) is a gut-selective biologic for ulcerative colitis and Crohn's disease, and though it does most of its work in the intestine, it has been linked to liver injury in rare cases.”
Reviewed by 2 · Jul 18, 2026
Where Great Plantain and Vedolizumab Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,048 of 1,452 supplements looked up here in the last 7 days
#2,222 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Great Plantain reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Great Plantain and Vedolizumab records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Great Plantain
What is Great Plantain?
- Minor wounds and skin irritation
- Insect bites and stings
- Coughs and sore throat
- Digestive upset
- Mild inflammation
Great Plantain is a common weed traditionally used on the skin for minor wounds and bites, and as a tea for coughs or stomach upset. Human evidence for most of these uses is limited, though the plant appears generally well tolerated. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.
Plantago major · Plantaginaceae · Leaves and seeds · Tea, capsules, tinctures, topical salves and ointments, fresh crushed leaves (poultice)
An interaction check asks whether these two react with each other — it does not ask whether Great Plantain is a good idea for someone in your situation. Here is what our Great Plantain record says about it on its own.
Great Plantain: dosing
There is no well-established standardized dose for Great Plantain. Traditional use varies widely, and the amount of active compounds differs between products and plant sources.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you and review your other medications and health conditions first.
From our Great Plantain monograph — the full record covers uses, side effects and every documented interaction.
About Vedolizumab Injection
What Is Vedolizumab Injection Used For?
Brand name: Entyvio
Vedolizumab Injection (sold as Entyvio) treats adults with moderately to severely active ulcerative colitis and moderately to severely active Crohn's disease. Both are long-term inflammatory conditions of the digestive tract.
It is given by vein (intravenous) and, after the first two infusions, can also be given as an injection under the skin (subcutaneous), including with the ENTYVIO Pen.
Most-Reported Side Effects for Vedolizumab
From FAERS, the FDA’s public side-effect reporting system (85,644 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Great Plantain
Browse every other medication we’ve checked against Great Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Great Plantain against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Amlodipine Besylate ›
- Docusate ›
- Valacyclovir ›
- Metformin ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Tadalafil ›
- Amitriptyline ›
- Semaglutide ›
- Levothyroxine, Liothyronine ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Acyclovir ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Great Plantain list.
Great Plantain References
The 3 references that drive our Great Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Great Plantain and Vedolizumab Together: Common Questions
Is it safe to take Great Plantain with Vedolizumab?
Do Great Plantain and Vedolizumab have any of the same side effects?
Are Great Plantain and Vedolizumab used for the same thing?
How was the Great Plantain and Vedolizumab combination checked?
Does Great Plantain interact with any other medications?
Does Vedolizumab interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Vedolizumab and Great Plantain?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.