Drug & supplement interaction

Gumweed + Mirikizumab-mrkz

Mirikizumab-mrkz brand name: Omvoh.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Gumweed and Mirikizumab-mrkz in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Gumweed and Mirikizumab-mrkz

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mirikizumab-mrkz and Gumweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Gumweed at all — not against Mirikizumab-mrkz, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gumweed safety at a glance

Gumweed overall Use caution Generally used in small amounts traditionally, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mirikizumab-mrkz and Gumweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Gumweed Itself Has Been Linked To

This is not an interaction — nothing below involves Mirikizumab-mrkz. It is the side-effect record for Gumweed on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Gumweed, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, gumweed seems to be well tolerated. It can cause gastric mucosal irritation (2,12), diarrhea (18), and kidney irritation (12).”

    Gumweed · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, gumweed can cause gastric mucosal irritation (2,12) and diarrhea (18).”

    Gumweed · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Gumweed — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Mirikizumab-mrkz’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Mirikizumab-mrkz column appears here.

Everything else you take

See Every Supplement That Interacts With Mirikizumab-mrkz

This page covers Gumweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mirikizumab-mrkz page lists 89 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Active Hexose Correlated Compound (ahcc) (moderate) and Alfalfa (moderate).

By severity: 3 major · 85 moderate · 1 minor.

From our pharmacist’s overview on the Mirikizumab-mrkz page

“Mirikizumab (Omvoh) treats inflammatory bowel disease by dialing down part of the immune system, and its interaction list deserves genuine wariness, most of all around the liver. The three most serious entries, Siberian cocklebur plus beer and wine, all raise the odds of liver damage when combined with a medication that can stress the…”

Reviewed by 2 · Jul 18, 2026

Open the Mirikizumab-mrkz interaction page

One more smart check

Taking Gumweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Gumweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gumweed. Even though Gumweed itself has no known interaction with Mirikizumab-mrkz, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gumweed and Mirikizumab-mrkz Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gumweed
Steady interest

#1,304 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mirikizumab-mrkz
Steady interest

#1,967 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gumweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Gumweed and Mirikizumab-mrkz records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gumweed

What is Gumweed?

  • Cough and bronchitis
  • Asthma-related breathing problems
  • Skin irritation from poison ivy or poison oak
  • Minor wounds and rashes
  • Upper respiratory congestion

Gumweed is a traditional North American plant used mostly for coughs, chest congestion, and skin irritation such as poison ivy rashes. Good-quality human studies are lacking, so its benefits are not well proven, and it should be used cautiously and avoided during pregnancy and breastfeeding.

Grindelia robusta · Asteraceae · Dried leaves and flowering tops · Tea, tincture, liquid extract, capsules, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Gumweed is a good idea for someone in your situation. Here is what our Gumweed record says about it on its own.

Gumweed: dosing

There is no well-established, standardized dose for gumweed. Traditional preparations include teas, tinctures, and liquid extracts, but the strength of commercial products varies widely.The safest approach is to follow the directions on the product label and not exceed the suggested amount.

From our Gumweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gumweed monograph & all interactions
Medication

About Mirikizumab-Mrkz

What Is Mirikizumab-Mrkz Used For?

Brand name: Omvoh

Omvoh (mirikizumab-mrkz) is used to treat moderately to severely active ulcerative colitis in adults — a condition where the large intestine becomes chronically inflamed and ulcerated. It is also used to treat moderately to severely active Crohn's disease in adults, another form of inflammatory bowel disease that can affect any part of the digestive tract.

Both uses are specific to Omvoh administered by injection — first as intravenous (into the vein) infusions to start treatment, then as subcutaneous (under the skin) injections for ongoing maintenance.

See full Mirikizumab-Mrkz drug information
Keep checking

Other Drugs & Gumweed

Browse every other medication we’ve checked against Gumweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Gumweed References

The 3 references that drive our Gumweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gumweed and Mirikizumab-mrkz Together: Common Questions

Is it safe to take Gumweed with Mirikizumab-mrkz?
We do not list a known interaction between Gumweed and Mirikizumab-mrkz. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Mirikizumab-mrkz interact with any supplements?
Yes. Mirikizumab-mrkz has documented interactions with 89 supplements in our database — Gumweed is not one of them. The Mirikizumab-mrkz interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Mirikizumab-mrkz and Gumweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.