Drug & supplement interaction

Herb Robert + Leflunomide

Leflunomide brand name: Arava.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Herb Robert and Leflunomide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Herb Robert and Leflunomide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leflunomide and Herb Robert in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Herb Robert at all — not against Leflunomide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Herb Robert safety at a glance

Herb Robert overall Use caution Generally used in small amounts traditionally, but human safety data are very limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exist for nursing mothers, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leflunomide and Herb Robert? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Herb Robert and Leflunomide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe skin reaction Worth acting on Additional detail

    Herb Robert

    “Topically, Herb Robert can cause contact dermatitis. There are at least two cases of known contact sensitization of elderly individuals to Herb Robert through gardening. One case resulted in an erythema multiforme-like eruption requiring treatment with steroids.”

    Herb Robert · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 99144. Svendsen MT, Andersen KE, Thormann H, Paulsen E. Contact sensitization to Geranium robertianum L. in an amateur gardener. Contact Dermatitis. 2015;72(6):420-1.
    2. 99146. Badaoui A, Pecquet C, Fargeas C, Mahé E. Contact dermatitis caused by Geranium robertianum with erythema multiforme-like reaction. Contact Dermatitis. 2017;77(6):423-424.

    Leflunomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Leflunomide. Read the label on DailyMed ›

  • A skin rash reported in 13.2% of FDA reports for Leflunomide Additional detail

    Herb Robert

    “There is currently a limited amount of information on the adverse effects of Herb Robert. Topically, Herb Robert has been reported to cause allergic contact dermatitis.”

    Herb Robert · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 99144. Svendsen MT, Andersen KE, Thormann H, Paulsen E. Contact sensitization to Geranium robertianum L. in an amateur gardener. Contact Dermatitis. 2015;72(6):420-1.
    2. 99146. Badaoui A, Pecquet C, Fargeas C, Mahé E. Contact dermatitis caused by Geranium robertianum with erythema multiforme-like reaction. Contact Dermatitis. 2017;77(6):423-424.

    Leflunomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Leflunomide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Leflunomide come from the ADVERSE REACTIONS section of its FDA label; effects for Herb Robert come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 104,033 voluntary FDA FAERS reports for Leflunomide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Leflunomide

This page covers Herb Robert only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leflunomide page lists 59 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 46 moderate · 9 minor.

From our pharmacist’s overview on the Leflunomide page

“Leflunomide (Arava) quiets rheumatoid arthritis by damping down the immune system, and its best-known danger is liver injury, so the 59 supplements and herbs on this page are worth slowing down for. Thirty-eight of them carry liver risks of their own, and of the four rated major, two are simply alcoholic drinks, while a third, Siberian…”

Reviewed by 2 · Jul 18, 2026

Open the Leflunomide interaction page

How much people look this up

Where Herb Robert and Leflunomide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Herb Robert
Steady interest

#827 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leflunomide
Steady interest

#1,505 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Herb Robert reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Herb Robert and Leflunomide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Herb Robert

What is Herb Robert?

Herb Robert
  • Digestive upset
  • Wound and skin care
  • Sore throat and mouth irritation
  • Respiratory complaints
  • General 'detox' tonic

Herb Robert is a traditional European herb used for digestion, wounds, and minor inflammation, but there is very little human research to confirm it works for any condition. It is likely fine in small amounts as a tea for most healthy adults, but its safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Geranium robertianum · Geraniaceae · Above-ground parts (leaves, stems, and flowers) · Tea, tincture, dried herb, capsules, fresh poultice

An interaction check asks whether these two react with each other — it does not ask whether Herb Robert is a good idea for someone in your situation. Here is what our Herb Robert record says about it on its own.

Herb Robert: dosing

There is no established, standardized dose for Herb Robert. Traditional use involved brewing a small amount of the dried herb as a tea or applying crushed fresh leaves to the skin, but these amounts were not measured in a consistent, science-based way.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Herb Robert monograph — the full record covers uses, side effects and every documented interaction.

Read the full Herb Robert monograph & all interactions
Medication

About Leflunomide

What Is Leflunomide Used For?

Brand name: Arava

Leflunomide tablets — sold under the brand name Arava and as generic leflunomide — are used to treat active rheumatoid arthritis (RA) in adults. Both Arava and generic leflunomide tablets are FDA-approved for this use.

Rheumatoid arthritis is an autoimmune condition in which the immune system attacks the joints, causing pain, swelling, and stiffness. Leflunomide helps calm that overactive immune response to reduce symptoms and slow joint damage.

Most-Reported Side Effects for Leflunomide

From FAERS, the FDA’s public side-effect reporting system (104,033 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Rheumatoid arthritis 25,337 reports
Arthralgia 17,395 reports
Drug intolerance 15,935 reports
Joint swelling 15,925 reports
Fatigue 15,756 reports
See full Leflunomide drug information
Keep checking

Other Drugs & Herb Robert

Browse every other medication we’ve checked against Herb Robert — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Herb Robert against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Herb Robert list.

See the full Herb Robert interactions page
See every supplement checked against Leflunomide, ranked by severity
Evidence & sources

Herb Robert References

The 3 references that drive our Herb Robert monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Svendsen MT, Andersen KE, Thormann H, Paulsen E. Contact sensitization to Geranium robertianum L. in an amateur gardener. Contact Dermatitis. 2015;72(6):420-1.
  2. Panahi Y, Akhavan A, Sahebkar A, et al. Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: a comparative trial with ciprofloxacin. J Microbi PubMed
  3. Badaoui A, Pecquet C, Fargeas C, Mahé E. Contact dermatitis caused by Geranium robertianum with erythema multiforme-like reaction. Contact Dermatitis. 2017;77(6):423-424.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Herb Robert and Leflunomide Together: Common Questions

Is it safe to take Herb Robert with Leflunomide?
We do not list a known interaction between Herb Robert and Leflunomide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Herb Robert and Leflunomide have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Leflunomide interact with any supplements?
Yes. Leflunomide has documented interactions with 59 supplements in our database — Herb Robert is not one of them. The Leflunomide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Herb Robert monograph Uses, safety profile, and every drug interaction in one place Leflunomide drug information The full plain-English guide to this medication Leflunomide supplement interactions Every supplement checked against Leflunomide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leflunomide and Herb Robert?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.