Drug & supplement interaction

Hydroxymethylbutyrate (hmb) + Albuterol

Albuterol brand names: Proventil, Volmax, Ventolin (U.S.), ProAir HFA.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hydroxymethylbutyrate (hmb) and Albuterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hydroxymethylbutyrate (hmb) and Albuterol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Albuterol and Hydroxymethylbutyrate (hmb) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hydroxymethylbutyrate (hmb) at all — not against Albuterol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hydroxymethylbutyrate (hmb) safety at a glance

Hydroxymethylbutyr... overall Use caution Generally well tolerated in healthy adults for short-term use, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Albuterol and Hydroxymethylbutyrate (hmb)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hydroxymethylbutyrate (hmb) Itself Has Been Linked To

This is not an interaction — nothing below involves Albuterol. It is the side-effect record for Hydroxymethylbutyrate (hmb) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hydroxymethylbutyrate (hmb), this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    “Orally, high blood pressure has been reported in one person taking HMB in a clinical trial.”

    Hydroxymethylbutyrate (hmb) · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 108770. Osuka Y, Kojima N, Sasai H, et al. Effects of exercise and/or ß-hydroxy-ß-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial. A PubMed
  • Heartburn / Bloating or gas / Stomach upset / Constipation / Stomach pain / Nausea Additional detail

    “Orally, abdominal pain, constipation, dyspepsia, flatulence, heartburn, and nausea have been reported rarely in people taking HMB in clinical trials.”

    Hydroxymethylbutyrate (hmb) · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 99245. Berton L, Bano G, Carraro S, et al. Effect of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical performance in healthy old women over 65 years: An open label randomized controlled trial. PLoS One. 2015;10(11):e0141757. PubMed
    2. 102872. Tritto AC, Bueno S, Rodrigues RMP, Gualano B, Roschel H, Artioli GG. Negligible effects of ß-hydroxy-ß-methylbutyrate free acid and calcium salt on strength and hypertrophic responses to resistance training: a randomized, placebo-controlled study. Int J S PubMed
    3. 108770. Osuka Y, Kojima N, Sasai H, et al. Effects of exercise and/or ß-hydroxy-ß-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial. A PubMed
  • Itching Additional detail

    “Orally, itching has been reported in two people taking HMB in clinical trials.”

    Hydroxymethylbutyrate (hmb) · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 99245. Berton L, Bano G, Carraro S, et al. Effect of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical performance in healthy old women over 65 years: An open label randomized controlled trial. PLoS One. 2015;10(11):e0141757. PubMed
    2. 102872. Tritto AC, Bueno S, Rodrigues RMP, Gualano B, Roschel H, Artioli GG. Negligible effects of ß-hydroxy-ß-methylbutyrate free acid and calcium salt on strength and hypertrophic responses to resistance training: a randomized, placebo-controlled study. Int J S PubMed

Everything above comes from the Natural Medicines adverse-effect record for Hydroxymethylbutyrate (hmb) — expand a row for the licensed statement it rests on. We haven’t matched Albuterol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Albuterol.

From our Q&A

Questions About Hydroxymethylbutyrate (hmb) or Albuterol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hydroxymethylbutyrate (hmb) or Albuterol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Albuterol

This page covers Hydroxymethylbutyrate (hmb) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Albuterol page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Black Tea (moderate), Caffeine (moderate), Cocoa (moderate) and Coffee (moderate).

By severity: 1 major · 22 moderate · 9 minor.

From our pharmacist’s overview on the Albuterol page

“Albuterol is a rescue drug; when an asthma attack hits, a Ventolin or ProAir inhaler has to work, which is why this list deserves a careful read rather than a skim. Of the 32 ingredients on file, activated charcoal alone is rated major, since it can soak up the drug and blunt its effect no matter how the albuterol was taken.”

Reviewed by 2 · Jul 18, 2026

Open the Albuterol interaction page

How much people look this up

Where Hydroxymethylbutyrate (hmb) and Albuterol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hydroxymethylbutyrate (hmb)
Steady interest

#1,013 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Albuterol
Steady interest

#1,803 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hydroxymethylbutyrate (hmb) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hydroxymethylbutyrate (hmb) and Albuterol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hydroxymethylbutyrate (hmb)

What is Hydroxymethylbutyrate (hmb)?

  • Building or preserving muscle mass
  • Improving strength with resistance training
  • Reducing muscle breakdown
  • Supporting recovery after exercise
  • Preventing muscle loss in older adults or illness

HMB is a compound made in the body from the amino acid leucine and is sold as a supplement mainly to support muscle. The best evidence suggests it may help slow muscle loss in certain situations, such as during illness, bed rest, or aging, but results in healthy athletes are mixed. It appears generally well tolerated for most adults, but you should check with your pharmacist or doctor before starting it.

Not applicable (HMB is a metabolite of the amino acid leucine) · Capsules, tablets, powder, drink mixes; available as calcium-HMB (CaHMB) and free-acid HMB

An interaction check asks whether these two react with each other — it does not ask whether Hydroxymethylbutyrate (hmb) is a good idea for someone in your situation. Here is what our Hydroxymethylbutyrate (hmb) record says about it on its own.

Hydroxymethylbutyrate (hmb): dosing

There is no single official dose of HMB, and the best amount depends on the goal and the person. Most research has used HMB taken in divided doses across the day, often alongside resistance training or protein intake.The two common forms are calcium-HMB and free-acid HMB, which may be absorbed differently.

From our Hydroxymethylbutyrate (hmb) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hydroxymethylbutyrate (hmb) monograph & all interactions
Medication

About Albuterol

What Is Albuterol Used For?

Brand names: Proventil, Volmax, Ventolin (U.S.), ProAir HFA

Albuterol is used to treat or prevent bronchospasm — sudden tightening of the airways — in adults and children with reversible obstructive airway disease, such as asthma. Most inhaled formulations (HFA inhalers, dry-powder inhalers, and nebulizer solutions) are approved for patients 4 years and older, though some nebulizer solutions are approved for children as young as 2, and the oral syrup covers adults and children 2 and older. Albuterol tablets are approved for adults and children 6 and older.

Albuterol inhaled products are also used to prevent exercise-induced bronchospasm in patients 4 years and older. The inhaled aerosol solution (0.5%) is approved specifically for relief of bronchospasm and acute attacks in patients 12 and older. Not every formulation covers every use — follow the instructions for the specific product you have been prescribed.

See full Albuterol drug information
Keep checking

Other Drugs & Hydroxymethylbutyrate (hmb)

Browse every other medication we’ve checked against Hydroxymethylbutyrate (hmb) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hydroxymethylbutyrate (hmb) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hydroxymethylbutyrate (hmb) list.

See the full Hydroxymethylbutyrate (hmb) interactions page
See every supplement checked against Albuterol, ranked by severity
Evidence & sources

Hydroxymethylbutyrate (hmb) References

The 3 references that drive our Hydroxymethylbutyrate (hmb) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Berton L, Bano G, Carraro S, et al. Effect of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical performance in healthy old women over 65 years: An open label randomized controlled trial. PLoS One. 2015;10(11):e0141757. PubMed
  2. Tritto AC, Bueno S, Rodrigues RMP, Gualano B, Roschel H, Artioli GG. Negligible effects of ß-hydroxy-ß-methylbutyrate free acid and calcium salt on strength and hypertrophic responses to resistance training: a randomized, placebo-controlled study. Int J S PubMed
  3. Osuka Y, Kojima N, Sasai H, et al. Effects of exercise and/or ß-hydroxy-ß-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial. A PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hydroxymethylbutyrate (hmb) and Albuterol Together: Common Questions

Is it safe to take Hydroxymethylbutyrate (hmb) with Albuterol?
We do not list a known interaction between Hydroxymethylbutyrate (hmb) and Albuterol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Albuterol interact with any supplements?
Yes. Albuterol has documented interactions with 32 supplements in our database — Hydroxymethylbutyrate (hmb) is not one of them. The Albuterol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hydroxymethylbutyrate (hmb) monograph Uses, safety profile, and every drug interaction in one place Albuterol drug information The full plain-English guide to this medication Albuterol supplement interactions Every supplement checked against Albuterol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.