Hyland's Restless Legs + Ketoconazole
Ketoconazole brand name: Nizoral.
We found no known interaction between Hyland's Restless Legs and Ketoconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Hyland's Restless Legs and Ketoconazole
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ketoconazole and Hyland's Restless Legs in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Hyland's Restless Legs at all — not against Ketoconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Hyland's Restless Legs safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
In most situations, clinically significant interactions between homeopathic products and prescription or over-the-counter medications are extremely unlikely.
Homeopathic medications, which utilize the principle of 'like cures like', are often highly diluted substances. These dilutions are typically so high that the final remedy contains only a tiny amount of the original active ingredient, if any at all.
In theory, because the concentration of the active ingredient is so low, homeopathic preparations are unlikely to interact with other medications in the body.
This is certainly the case with Hyland's Restful Legs, with all the ingredients diluted at potencies of 6X or 12X. A potency of 6X means that the original substance has been diluted by a factor of 10^6, or one part in a million (i.e., for every million parts of the solution, there is one part of the original substance).
It is important to note that not all homeopathic remedies are free of potential drug interactions as some use very low dilutions (which is often the case with zinc-containing products).
Nevertheless, there are no known drug interactions between Hyland's Restful Legs and other medications. It is also thought to be safe to take along with medications to help sleep, like Benadryl, melatonin, and NyQuil, which are commonly used with the product to help sleep.
Questions About Hyland's Restless Legs or Ketoconazole
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hyland's Restless Legs or Ketoconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Ketoconazole
This page covers Hyland's Restless Legs only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoconazole page lists 182 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 135 moderate · 41 minor.
From our pharmacist’s overview on the Ketoconazole page
“Ketoconazole (Nizoral) is already hard on the liver, so treat its 182 interacting supplements with genuine care, starting with the six rated major. Most of the list runs through CYP3A4, the liver enzyme ketoconazole strongly blocks, so it can raise levels of over a hundred herbal ingredients, while grapefruit pushes ketoconazole itself…”
Reviewed by 2 · Jul 18, 2026
Where Hyland's Restless Legs and Ketoconazole Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,248 of 1,452 supplements looked up here in the last 7 days
#1,748 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Hyland's Restless Legs is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hyland's Restless Legs reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hyland's Restless Legs and Ketoconazole records this page draws on were last updated June 20, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Hyland's Restless Legs
What is Hyland's Restless Legs?
- Restless legs sensations
- Urge to move the legs
- Leg twitching or jerking
- Crawling or itching feelings in the legs
- Trouble resting due to leg discomfort
Hyland's Restful Legs (often called 'Restless Legs') is a homeopathic product marketed to calm agitated legs so you can rest. Its ingredients are extremely diluted, and there is no strong scientific evidence that it relieves restless legs syndrome. If you have ongoing leg symptoms, talk with a pharmacist or doctor, since restless legs can have treatable underlying causes such as low iron.
Highly diluted homeopathic ingredients (not a single plant part) · Quick-dissolving tablets (daytime and nighttime/PM versions)
An interaction check asks whether these two react with each other — it does not ask whether Hyland's Restless Legs is a good idea for someone in your situation. Here is what our Hyland's Restless Legs record says about it on its own.
Hyland's Restless Legs: dosing
There is no scientifically established dose for this product, since it has not been proven effective in clinical trials. Always follow the directions on the package label. Do not exceed the labeled amount, and do not use it as a substitute for treatments your doctor has recommended.
From our Hyland's Restless Legs monograph — the full record covers uses, side effects and every documented interaction.
About Ketoconazole
What Is Ketoconazole Used For?
Brand name: Nizoral
Ketoconazole 2% shampoo and foam are used to treat tinea versicolor (also called pityriasis versicolor) — a fungal infection caused by Pityrosporum orbiculare (also known as Malassezia furfur), a yeast that naturally lives on the skin.
This infection creates light or dark patches, most often on the trunk, neck, arms, and upper thighs. Even after the fungus is cleared, those skin patches may take months to return to their normal color — that's normal, and depends on your skin type and sun exposure. Tinea versicolor can also come back, since the fungus lives on healthy skin even when there's no active infection.
Most-Reported Side Effects for Ketoconazole
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Hyland's Restless Legs
Browse every other medication we’ve checked against Hyland's Restless Legs — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Hyland's Restless Legs against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hyland's Restless Legs list.
Hyland's Restless Legs References
The 3 sources that drive our Hyland's Restless Legs monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Hyland's Restless Legs is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Homeopathy — NIH NCCIH Source
- Restless Legs Syndrome — MedlinePlus Source
- Homeopathic Products — U.S. Food and Drug Administration Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Hyland's Restless Legs and Ketoconazole Together: Common Questions
Is it safe to take Hyland's Restless Legs with Ketoconazole?
Does Ketoconazole interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.