Drug & supplement interaction

Indian Gooseberry + Ibuprofen, Hydrocodone

Ibuprofen, Hydrocodone brand name: Ibucodone.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Indian Gooseberry has a moderate interaction with Ibuprofen, Hydrocodone. Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Indian Gooseberry and Ibuprofen, Hydrocodone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ibuprofen, Hydrocodone

Ibuprofen, Hydrocodone falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Indian Gooseberry interacts with.

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep an eye on with this combination product. The ibuprofen part of Ibucodone already has its own effect on platelets, meaning it can make your blood a little slower to clot. Indian gooseberry (amla) seems to do something similar on its own. Some research found amla 500 mg reduced platelet stickiness and modestly lengthened bleeding time. So stacking the two could, in theory, add up to a bit more bleeding risk.

What that looks like in real life: easier bruising, nosebleeds, stomach upset, or dark stools (a sign of stomach bleeding, which ibuprofen can already cause). The evidence here is mixed and mostly theoretical, so a little amla in food is unlikely to matter. With concentrated supplements, please check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Indian Gooseberry Also Interacts With Other Medications

Indian Gooseberry has 207 moderate known drug interactions in our database — the Ibuprofen, Hydrocodone one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Ibuprofen, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Indian Gooseberry

Covers the 2,830 medications we’ve checked against Indian Gooseberry. Pick one to open its full report.

From our Q&A

Questions About Indian Gooseberry or Ibuprofen, Hydrocodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Indian Gooseberry or Ibuprofen, Hydrocodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Hydrocodone

This page covers Indian Gooseberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Hydrocodone page lists 356 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 303 moderate · 40 minor.

From our pharmacist’s overview on the Ibuprofen, Hydrocodone page

“Mixing supplements with Ibucodone (ibuprofen plus hydrocodone) carries real risk, and 13 of the 356 ingredients on this page rate major. Ibuprofen already raises bleeding risk, so the largest cluster here, over 200 ingredients, can add to it.”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen, Hydrocodone interaction page

One more smart check

Taking Indian Gooseberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,248 real supplement products containing Indian Gooseberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indian Gooseberry. Your product may carry other ingredients that interact with Ibuprofen, Hydrocodone too, on top of Indian Gooseberry — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indian Gooseberry and Ibuprofen, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indian Gooseberry
Top 10%

#106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Hydrocodone
Steady interest

#2,004 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Indian Gooseberry

What is Indian Gooseberry?

Indian Gooseberry
  • Antioxidant support
  • Cholesterol and heart health
  • Immune support
  • Digestive health
  • Skin and hair care

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some uses like cholesterol, but most claims are not yet proven by strong human studies. It is generally well tolerated as a food, but talk to your pharmacist or doctor before taking concentrated supplements.

Read the full Indian Gooseberry monograph & all interactions
Keep checking

Other Drugs & Indian Gooseberry

Browse every other medication we’ve checked against Indian Gooseberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Indian Gooseberry page.

No interaction 2,622 drugs checked — show the list

We also checked Indian Gooseberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Indian Gooseberry list.

See the full Indian Gooseberry interactions page
See every supplement checked against Ibuprofen, Hydrocodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Indian Gooseberry monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Hydrocodone supplement interactions › Every supplement checked against Ibuprofen, Hydrocodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Indian Gooseberry and Ibuprofen, Hydrocodone Together: Common Questions

Can you take Indian Gooseberry with Ibuprofen, Hydrocodone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Indian Gooseberry and Ibuprofen, Hydrocodone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.