Drug & supplement interaction

Indian Gooseberry + Siltuximab

Siltuximab brand name: Sylvant.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Indian Gooseberry and Siltuximab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Indian Gooseberry and Siltuximab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Siltuximab and Indian Gooseberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indian Gooseberry safety at a glance

Indian Gooseberry overall Use caution Generally well tolerated as a food, but supplement safety is less studied.
Pregnancy Avoid Not enough safety data for supplement doses, so it is best to avoid.
Breastfeeding Avoid There is too little reliable safety information during breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Siltuximab and Indian Gooseberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Siltuximab

Interactions in our licensed database are recorded against drug classes, not just single drug names. Siltuximab is filed under a single classification — cytochrome p450 3a4 (cyp3a4) substrates. Indian Gooseberry has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and aspirin (moderate) — and none of Siltuximab’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indian Gooseberry Does Interact With Other Medications

Indian Gooseberry has 208 moderate known drug interactions in our database — Siltuximab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Siltuximab)
Taking anything else?

Check Another of Your Medications Against Indian Gooseberry

Covers the 2,830 medications we’ve checked against Indian Gooseberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Indian Gooseberry and Siltuximab May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Indian Gooseberry

    “Orally, itching has been reported by one individual in a clinical trial.”

    Indian Gooseberry · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 105354. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro

    Siltuximab

    Listed in the ADVERSE REACTIONS section of the FDA label for Siltuximab. Read the label on DailyMed ›

Reported for Indian Gooseberry but not commonly for Siltuximab: stomach upset, muscle pain and tiredness.

Effects for Siltuximab come from the ADVERSE REACTIONS section of its FDA label; effects for Indian Gooseberry come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Siltuximab Is Prescribed For, and What Indian Gooseberry Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Siltuximab is a prescription medicine with approved uses on its FDA label. Indian Gooseberry is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Siltuximab is prescribed for: Sylvant (siltuximab) injection is approved to treat multicentric Castleman's disease (MCD) — a rare disorder involving abnormal lymph node growth driven by an overactive immune signal called IL-6. It is specifically approved for patients who test negative for both HIV and HHV-8 (human herpesvirus-8). Sylvant has not been studied in patients with MCD who are HIV-positive or HHV-8-positive, because it does not block the form of IL-6 produced by those viruses.

Indian Gooseberry has been studied for:

  • Cancer studied, not established Indian Gooseberry has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Indian Gooseberry for cancer

    Although there is interest in using oral Indian gooseberry for cancer, there is insufficient reliable information about the clinical effects of Indian gooseberry for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Siltuximab on your own; if you are taking Indian Gooseberry for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Indian Gooseberry or Siltuximab

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Indian Gooseberry or Siltuximab, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Siltuximab

This page covers Indian Gooseberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Siltuximab page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Siltuximab page

“Genuine care is warranted with siltuximab (Sylvant), the infusion for multicentric Castleman disease, and the place to start is its two major-rated interactions: grapefruit and St. John's wort.”

Reviewed by 2 · Jul 18, 2026

Open the Siltuximab interaction page

One more smart check

Taking Indian Gooseberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,248 real supplement products containing Indian Gooseberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indian Gooseberry. Even though Indian Gooseberry itself has no known interaction with Siltuximab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indian Gooseberry and Siltuximab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indian Gooseberry
Top 10%

#102 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Siltuximab
Steady interest

#2,702 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indian Gooseberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Indian Gooseberry and Siltuximab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indian Gooseberry

What is Indian Gooseberry?

Indian Gooseberry
  • Antioxidant support
  • Cholesterol and heart health
  • Immune support
  • Digestive health
  • Skin and hair care

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some uses like cholesterol, but most claims are not yet proven by strong human studies. It is generally well tolerated as a food, but talk to your pharmacist or doctor before taking concentrated supplements.

Phyllanthus emblica · Phyllanthaceae · Fruit (sometimes seeds, leaves, and bark) · Capsules, tablets, powder, juice, dried fruit, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Indian Gooseberry is a good idea for someone in your situation. Here is what our Indian Gooseberry record says about it on its own.

Indian Gooseberry: dosing

There is no official, standardized dose of Indian gooseberry. The right amount depends on the product, whether it is a juice, powder, or extract, and how concentrated it is.Because doses vary so much between products, the safest approach is to follow the directions on the product label. They can help you decide whether it is appropriate for you.

From our Indian Gooseberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indian Gooseberry monograph & all interactions
Medication

About Siltuximab Injection

What Is Siltuximab Injection Used For?

Brand name: Sylvant

Sylvant (siltuximab) injection is approved to treat multicentric Castleman's disease (MCD) — a rare disorder involving abnormal lymph node growth driven by an overactive immune signal called IL-6. It is specifically approved for patients who test negative for both HIV and HHV-8 (human herpesvirus-8).

Sylvant has not been studied in patients with MCD who are HIV-positive or HHV-8-positive, because it does not block the form of IL-6 produced by those viruses.

See full Siltuximab Injection drug information
Keep checking

Other Drugs & Indian Gooseberry

Browse every other medication we’ve checked against Indian Gooseberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Indian Gooseberry page.

No interaction 2,621 drugs checked — show the list

We also checked Indian Gooseberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Indian Gooseberry list.

See the full Indian Gooseberry interactions page
See every supplement checked against Siltuximab, ranked by severity
Evidence & sources

Indian Gooseberry References

The 6 references that drive our Indian Gooseberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indian Gooseberry and Siltuximab Together: Common Questions

Is it safe to take Indian Gooseberry with Siltuximab?
We do not list a known interaction between Indian Gooseberry and Siltuximab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Indian Gooseberry and Siltuximab have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Indian Gooseberry and Siltuximab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Indian Gooseberry in each. That is a conversation for your prescriber, especially if Siltuximab is being adjusted to a target.
How was the Indian Gooseberry and Siltuximab combination checked?
Interactions in our licensed database are recorded against drug classes. Siltuximab is filed under 1 classification, and Indian Gooseberry has documented interactions with 4 drug classes — none of Siltuximab's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Indian Gooseberry interact with any other medications?
Yes. Indian Gooseberry has 208 documented drug interactions in our database — Siltuximab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Siltuximab interact with any supplements?
Yes. Siltuximab has documented interactions with 121 supplements in our database — Indian Gooseberry is not one of them. The Siltuximab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indian Gooseberry monograph Uses, safety profile, and every drug interaction in one place Siltuximab Injection drug information The full plain-English guide to this medication Siltuximab supplement interactions Every supplement checked against Siltuximab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Siltuximab and Indian Gooseberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.