Jaborandi + Talbutal
Talbutal brand name: Lotusate.
We found no known interaction between Jaborandi and Talbutal in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Jaborandi and Talbutal
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Talbutal and Jaborandi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Jaborandi at all — not against Talbutal, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Jaborandi safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Jaborandi in Pregnancy & Breastfeeding
When used orally or topically because it has teratogenic and uterine stimulant effects and contains pilocarpine.
When used orally or topically because it contains pilocarpine.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Talbutal
This page covers Jaborandi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Talbutal page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Talbutal page
“Every one of the 17 supplements that interacts with Talbutal (Lotusate) works through your gut, changing how much of this barbiturate sleep aid actually reaches your bloodstream. That deserves genuine caution, because barbiturates leave little room for error.”
Reviewed by 2 · Jul 18, 2026
Taking Jaborandi as Part of a Dietary Supplement Product? Check It for Interactions
We hold 6 real supplement products containing Jaborandi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jaborandi. Even though Jaborandi itself has no known interaction with Talbutal, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Jaborandi and Talbutal Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#950 of 1,452 supplements looked up here in the last 7 days
#2,146 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jaborandi reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jaborandi and Talbutal records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Jaborandi
What is Jaborandi?
- Dry mouth (xerostomia)
- Glaucoma and high eye pressure
- Promoting sweating
- Increasing saliva production
- Traditional remedy for various ailments
Jaborandi is a South American plant best known as the natural source of pilocarpine, a drug used in modern medicine for glaucoma and dry mouth. The raw herb is potent and potentially toxic, so it is not something to use casually as a home remedy. If you need its effects, use the FDA-approved pilocarpine products prescribed by your doctor rather than the crude plant.
Pilocarpus microphyllus · Rutaceae · Leaves · Standardized pharmaceutical extract (pilocarpine), eye drops, tablets, and historically as a tea or tincture
An interaction check asks whether these two react with each other — it does not ask whether Jaborandi is a good idea for someone in your situation. Here is what our Jaborandi record says about it on its own.
Jaborandi: dosing
There is no established safe dose for the crude Jaborandi herb, and we do not recommend self-dosing with the raw plant because its potency is unpredictable and it can be toxic.The purified drug pilocarpine is a different story — it comes in carefully measured tablets and eye drops with doses set by a doctor.
From our Jaborandi monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Jaborandi
Browse every other medication we’ve checked against Jaborandi — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Jaborandi against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Rosuvastatin ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Ibuprofen ›
- Tirzepatide ›
- Docusate ›
- Methamphetamine ›
- Warfarin Sodium ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Propranolol ›
- Metformin ›
- Isotretinoin ›
- Lisdexamfetamine ›
- Methotrexate ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Doxycycline ›
- Acyclovir ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Lamotrigine ›
- Levothyroxine, Liothyronine ›
- Dextroamphetamine ›
- Quetiapine ›
- Naproxen ›
- Clonazepam ›
- Acetaminophen, Codeine ›
- Omeprazole ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Duloxetine ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Jaborandi list.
Jaborandi References
The 2 references that drive our Jaborandi monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Jaborandi and Talbutal Together: Common Questions
Is it safe to take Jaborandi with Talbutal?
Does Talbutal interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Talbutal and Jaborandi?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.