Jackfruit - Aspirin, Butalbital, Caffeine, Codeine Phosphate Interaction
Herbal: Jackfruit
Also Known As: Artocarpus heterophyllus, Arbol Del Pan, Baramil, Bo Luo Mi, Cakki, Chakka, Derakhte Nan, Falso Albero Del Pane, Fenesi, Finesy, Fruta Del Pobre, Halasina Hannu, Halasu, Indischer Brotfruchtbaum, Jaca, Jack, Jackfrucht, Jackfrugttrae, Jackfrukt, Jacktrad, Jacquier, Jak, Jaka, J
Drug: Aspirin, Butalbital, Caffeine, Codeine Phosphate
Brand names:
Fiorinal w/ Codeine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Aspirin, Butalbital, Caffeine, Codeine Phosphate is classified as belonging to the following category: Cns Depressants
Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.
Animal research shows that jackfruit seeds can cause sedation.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
Interaction Details
Aspirin, Butalbital, Caffeine, Codeine Phosphate is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, jackfruit latex might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Jackfruit latex, which is the sap from jackfruit bark, contains chemicals that might increase the risk of bleeding. In vitro research shows that jackfruit latex contains a glycoprotein constituent that prolongs the activated partial thrombin time (aPTT) and reduces the activity of blood coagulation factors XIa and alpha-XIIa. Jackfruit latex also contains a protease constituent that has been shown to have fibrinolytic activity in vitro. Other parts of jackfruit, including the fruit and leaves, have not been shown to contain chemicals with fibrinolytic and anticoagulant activity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
- Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
Jackfruit Overview
Jackfruit is a tropical fruit native to India and other parts of South and Southeast Asia. It is the largest tree-borne fruit in the world. It has a thick, spiky outer skin and a yellow, juicy flesh that is both sweet and slightly musky in flavor.
Jackfruit is a rich source of nutrients, including vitamins C and B6, potassium, and dietary fiber. It is also a good source of antioxidants. Jackfruit leaves, roots, bark, and latex have all been used for medicinal purposes.
Jackfruit - More Interactions
Jackfruit interacts with 433 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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