Drug & supplement interaction

Japanese Apricot + Anagrelide

Anagrelide brand name: Agrylin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Japanese Apricot has a moderate interaction with Anagrelide. Some constituents of Japanese apricot flower extract might have antiplatelet properties.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Japanese Apricot and Anagrelide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Anagrelide

Anagrelide falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Japanese Apricot interacts with.

Some constituents of Japanese apricot flower extract might have antiplatelet properties. Theoretically, combining Japanese flower extract with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising or bleeding. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with anagrelide and Japanese Apricot. Anagrelide already lowers your platelets, the cells that help your blood clot. Some lab research suggests compounds in Japanese apricot flower extract may have a mild blood-thinning (antiplatelet) effect of their own. Put the two together and, in theory, you could nudge up your risk of bruising or bleeding.

I want to be straight with you: this concern comes only from test-tube and animal studies, not from people, so it's quite theoretical. Eating umeboshi or apricot as a normal food is unlikely to be a problem. A concentrated extract supplement is where I'd be more cautious. Watch for easy bruising, nosebleeds, or bleeding that's slow to stop, and check with your pharmacist or doctor before adding it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Matsuda H, Morikawa T, Ishiwada T, et al. Medicinal flowers. VIII. Radical scavenging constituents from the flowers of Prunus mume: structure of prunose III. Chem Pharm Bull (Tokyo) 2003;51:440-3.. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Japanese Apricot Also Interacts With Other Medications

Japanese Apricot has 207 moderate known drug interactions in our database — the Anagrelide one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Anagrelide)
Taking anything else?

Check Another of Your Medications Against Japanese Apricot

Covers the 2,830 medications we’ve checked against Japanese Apricot. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Anagrelide

This page covers Japanese Apricot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Anagrelide page lists 265 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Adrafinil (moderate).

By severity: 3 major · 223 moderate · 39 minor.

From our pharmacist’s overview on the Anagrelide page

“Anagrelide (Agrylin) lowers platelet counts in people whose bone marrow makes too many, so bleeding risk is already the thing being managed, and most of this list pushes on exactly that. The bulk of these ingredients have some blood-thinning or antiplatelet activity of their own, from danshen and piracetam at the serious end down to fa…”

Reviewed by 2 · Jul 18, 2026

Open the Anagrelide interaction page

One more smart check

Taking Japanese Apricot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Japanese Apricot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Apricot. Your product may carry other ingredients that interact with Anagrelide too, on top of Japanese Apricot — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Apricot and Anagrelide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Apricot
Steady interest

#768 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Anagrelide
Top half

#1,126 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Japanese Apricot

What is Japanese Apricot?

  • Digestive upset
  • Fatigue and general wellness
  • Sore throat and cough
  • Antimicrobial support
  • Liver and detox support (traditional)

Japanese Apricot (Prunus mume) is a tart fruit used widely in East Asian foods and traditional medicine, often as pickled umeboshi or a concentrated extract. It has a long history of culinary and folk use, but high-quality human studies are limited, so most health claims remain unproven. The processed fruit is generally well tolerated as a food, but talk to a pharmacist or doctor before using concentrated supplements.

Read the full Japanese Apricot monograph & all interactions
Medication

About Anagrelide

What Is Anagrelide Used For?

Brand name: Agrylin

Anagrelide — sold as Agrylin and as generic anagrelide capsules — is used to treat thrombocythemia secondary to myeloproliferative neoplasms. That means it's prescribed when a bone marrow disorder causes the body to produce too many platelets, raising the risk of dangerous blood clots.

By bringing platelet counts down to a safer range, anagrelide also helps reduce related symptoms, including bleeding and clotting events (thrombo-hemorrhagic events).

See full Anagrelide drug information
Keep checking

Other Drugs & Japanese Apricot

Browse every other medication we’ve checked against Japanese Apricot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Japanese Apricot page.

No interaction 2,622 drugs checked — show the list

We also checked Japanese Apricot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Japanese Apricot list.

See the full Japanese Apricot interactions page
See every supplement checked against Anagrelide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Japanese Apricot monograph › Uses, safety, and every drug interaction in one place Anagrelide supplement interactions › Every supplement checked against Anagrelide, ranked by severity Anagrelide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Japanese Apricot and Anagrelide Together: Common Questions

Can you take Japanese Apricot with Anagrelide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Japanese Apricot and Anagrelide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Anagrelide and Japanese Apricot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.