Drug & supplement interaction

K2/spice + Finerenone

Finerenone brand name: Kerendia.

No Known Interaction
The bottom line No known interaction

We found no known interaction between K2/spice and Finerenone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

K2/spice and Finerenone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Finerenone and K2/spice in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

K2/spice safety at a glance

K2/spice overall Avoid These products are illegal, unregulated, and have caused serious harm and death.
Pregnancy Avoid Never use during pregnancy; it can seriously harm both mother and baby.
Breastfeeding Avoid Avoid while breastfeeding; chemicals can pass to the infant and cause harm.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Finerenone and K2/spice? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Finerenone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Finerenone is filed under 3 classifications — potassium-sparing diuretics, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. K2/spice has documented interactions with 2 drug classes — the most serious being anticonvulsants (moderate) and qt interval-prolonging drugs (moderate) — and none of Finerenone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

K2/spice Does Interact With Other Medications

K2/spice has 208 moderate known drug interactions in our database — Finerenone isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against K2/spice

Covers the 2,830 medications we’ve checked against K2/spice. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests K2/spice and Finerenone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on reported in 22.8% of FDA reports for Finerenone Additional detail

    K2/spice

    “When inhaled, K2/spice can cause acute kidney injury. More than 50 cases requiring hospitalization have been reported in patients who smoked K2/spice.”

    K2/spice · Natural Medicines adverse-effect record, reported in acute kidney injury (aki).

    3 sources cited
    1. 98847. Davidson C, Opacka-Juffry J, Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E, Molina-Holgado F. Spicing up pharmacology: a review of synthetic cannabinoids from structure to adverse events. Adv Pharmacol 2017;80:135-68. PubMed
    2. 99624. Tait RJ, Caldicott D, Mountain D, Hill SL, Lenton S. A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol (Phila) 2016;54(1):1-13. PubMed
    3. 111236. D'Errico S, Zanon M, Radaelli D, et al. Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers. Biomedicines 2022;10(8):1936. PubMed

    Finerenone

    Listed in the ADVERSE REACTIONS section of the FDA label for Finerenone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Heart failure Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice can cause serious adverse cardiovascular effects, including tachycardia or bradycardia, hypertension or hypotension, coronary vasospasm, acute coronary syndrome, congestive heart failure, ventricular fibrillation, QT prolongation, myocardial ischemia/infarction, stroke, cardiac arrest, cardiomyopathy, and sudden cardiac death.”

    K2/spice · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 98843. Andonian DO, Seaman SR, Josephson EB. Profound hypotension and bradycardia in the setting of synthetic cannabinoid intoxication - a case series. Am J Emerg Med 2017;35(6):940.e5-940.e6. PubMed
    2. 98844. McIlroy G, Ford L, Khan JM. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacol Toxicol 2016;17:2. PubMed
    3. 98846. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
    4. 98849. Freeman MJ, Rose DZ, Myers MA, Gooch CL, Bozeman AC, Burgin WS. Ischemic stroke after use of the synthetic marijuana "spice". Neurology 2013;81(24):2090-3. PubMed
    5. 99617. Law R, Schier J, Martin C, Chang A, Wolkin A; Centers for Disease Control (CDC). Notes from the field: increase in reported adverse health effects related to synthetic cannabinoid use - United States, January-May 2015. MMWR Morb Mortal Wkly Rep 2015;64(22
    6. 99619. Monte AA, Calello DP, Gerona RR, et al. Characteristics and treatment of patients with clinical illness due to synthetic cannabinoid inhalation reported by medical toxicologists: a ToxIC database study. J Med Toxicol 2017;13(2):146-52. PubMed

    Finerenone

    Listed in the ADVERSE REACTIONS section of the FDA label for Finerenone. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    K2/spice

    Recorded for K2/spice in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Finerenone

    Listed in the ADVERSE REACTIONS section of the FDA label for Finerenone. Read the label on DailyMed ›

Reported for K2/spice but not commonly for Finerenone: confusion, a heart attack, memory problems and shortness of breath.

Effects for Finerenone come from the ADVERSE REACTIONS section of its FDA label; effects for K2/spice come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,960 voluntary FDA FAERS reports for Finerenone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About K2/spice or Finerenone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers K2/spice or Finerenone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Finerenone

This page covers K2/spice only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Finerenone page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 101 moderate · 42 minor.

From our pharmacist’s overview on the Finerenone page

“Kerendia (finerenone) protects the kidneys and heart in people with type 2 diabetes and chronic kidney disease, and because the body clears it through one main enzyme, CYP3A4, its supplement list calls for genuine care. Of the 146 ingredients on file, 121 can push that enzyme up or down, letting finerenone drift too high or too low.”

Reviewed by 2 · Jul 18, 2026

Open the Finerenone interaction page

How much people look this up

Where K2/spice and Finerenone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement K2/spice
Steady interest

#816 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Finerenone
Steady interest

#1,532 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every K2/spice reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The K2/spice and Finerenone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About K2/spice

What is K2/spice?

  • Recreational drug ('legal high')
  • Marijuana substitute
  • Mood or perception changes
  • Sometimes used to avoid drug testing

K2/Spice is NOT a herbal supplement — it is plant material sprayed with man-made synthetic cannabinoid chemicals. It is dangerous, unpredictable, and has caused seizures, heart problems, psychosis, and deaths, so it should not be used.

Not a plant part; synthetic chemicals sprayed onto dried plant material · Dried plant material that is smoked or vaped; sometimes sold as liquid for vaping

An interaction check asks whether these two react with each other — it does not ask whether K2/spice is a good idea for someone in your situation. Here is what our K2/spice record says about it on its own.

K2/spice: dosing

There is no safe or recommended dose of K2/Spice. Because these are unregulated, illegal products with unknown and constantly changing ingredients, no dose can be considered safe. The strength can vary wildly even within a single package.This is not a supplement that should be taken at any amount. If you are looking for help with substance use, please reach out to a healthcare provider, pharmacist, or a substance-use support service.

From our K2/spice monograph — the full record covers uses, side effects and every documented interaction.

Read the full K2/spice monograph & all interactions
Medication

About Finerenone

What Is Finerenone Used For?

Brand name: Kerendia

Kerendia (finerenone) is used in adults with chronic kidney disease (CKD) linked to type 2 diabetes. It helps reduce the risk of kidney function decline, end-stage kidney disease, cardiovascular death, non-fatal heart attack, and hospitalization for heart failure in these patients.

Kerendia is also used in adults with heart failure who have a left ventricular ejection fraction (LVEF) — a measure of how well the heart pumps — of 40% or higher. In this group, it reduces the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits.

Most-Reported Side Effects for Finerenone

From FAERS, the FDA’s public side-effect reporting system (2,960 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Glomerular filtration rate decreased 308 reports
Hyperkalaemia 261 reports
Blood creatinine increased 226 reports
Blood potassium increased 180 reports
Renal impairment 140 reports
See full Finerenone drug information
Keep checking

Other Drugs & K2/spice

Browse every other medication we’ve checked against K2/spice — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the K2/spice page.

No interaction 2,621 drugs checked — show the list
Evidence & sources

K2/spice References

The 40 references that drive our K2/spice monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Amar JY, Ruta J, Rahimian D, Dillinger RL, Katz P. Toxic leukoencephalopathy with extrapyramidal dysfunction due to synthetic cannabinoids. J Clin Neurosci 2018;58:213-4. PubMed
  2. Andonian DO, Seaman SR, Josephson EB. Profound hypotension and bradycardia in the setting of synthetic cannabinoid intoxication - a case series. Am J Emerg Med 2017;35(6):940.e5-940.e6. PubMed
  3. McIlroy G, Ford L, Khan JM. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacol Toxicol 2016;17:2. PubMed
  4. Chinnadurai T, Shrestha S, Ayinla R. A curious case of inhalation fever caused by synthetic cannabinoid. Am J Case Rep 2016;17:379-83. PubMed
  5. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  6. Davidson C, Opacka-Juffry J, Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E, Molina-Holgado F. Spicing up pharmacology: a review of synthetic cannabinoids from structure to adverse events. Adv Pharmacol 2017;80:135-68. PubMed
  7. Durand D, Delgado LL, de la Parra-Pellot DM, Nichols-Vinueza D. Psychosis and severe rhabdomyolysis associated with synthetic cannabinoid use: a case report. Clin Schizophr Relat Psychoses 2015;8(4):205-8. DOI
  8. Freeman MJ, Rose DZ, Myers MA, Gooch CL, Bozeman AC, Burgin WS. Ischemic stroke after use of the synthetic marijuana "spice". Neurology 2013;81(24):2090-3. PubMed
  9. Kelkar AH, Smith NA, Martial A, Moole H, Tarantino MD, Roberts JC. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med 2018;379(13):1216-23. PubMed
  10. Lamy FR, Daniulaityte R, Nahhas RW, et al. Increases in synthetic cannabinoids-related harms: results from a longitudinal web-based content analysis. Int J Drug Policy. 2017;44:121-9. PubMed
  11. Law R, Schier J, Martin C, Chang A, Wolkin A; Centers for Disease Control (CDC). Notes from the field: increase in reported adverse health effects related to synthetic cannabinoid use - United States, January-May 2015. MMWR Morb Mortal Wkly Rep 2015;64(22
  12. Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA. Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 2014;144:12-41. PubMed
  13. Monte AA, Calello DP, Gerona RR, et al. Characteristics and treatment of patients with clinical illness due to synthetic cannabinoid inhalation reported by medical toxicologists: a ToxIC database study. J Med Toxicol 2017;13(2):146-52. PubMed
  14. Öztürk E, Oral A, Özdemir M, Bambul N. Synthetic marijuana "K2" induced ITP. Platelets 2015;26(3):258-9. PubMed
  15. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR. A common source outbreak of severe delirium associated with exposure to the novel synthetic cannabinoid ADB-PINACA. J Emerg Med 2015;48(5):573-80. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking K2/spice and Finerenone Together: Common Questions

Is it safe to take K2/spice with Finerenone?
We do not list a known interaction between K2/spice and Finerenone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do K2/spice and Finerenone have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the K2/spice and Finerenone combination checked?
Interactions in our licensed database are recorded against drug classes. Finerenone is filed under 3 classifications, and K2/spice has documented interactions with 2 drug classes — none of Finerenone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does K2/spice interact with any other medications?
Yes. K2/spice has 208 documented drug interactions in our database — Finerenone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Finerenone interact with any supplements?
Yes. Finerenone has documented interactions with 146 supplements in our database — K2/spice is not one of them. The Finerenone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Finerenone and K2/spice?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.