Kale + Everolimus
Everolimus brand names: Certican, Afinitor, Zortress, Afinitor Disperz.
We found no known interaction between Kale and Everolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Kale and Everolimus
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Everolimus and Kale in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Kale at all — not against Everolimus, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Kale safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Kale in Pregnancy & Breastfeeding
When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of kale when used orally in medicinal amounts; avoid use.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Everolimus Is Prescribed For, and What Kale Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Everolimus is a prescription medicine with approved uses on its FDA label. Kale is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Everolimus is prescribed for: Everolimus is used to treat several serious conditions. In cancer, it is prescribed for advanced hormone receptor-positive, HER2-negative breast cancer (in postmenopausal women), certain neuroendocrine tumors of the pancreas, GI tract, or lung, and advanced renal cell carcinoma (kidney cancer) when other treatments have stopped working. It is also used for people with tuberous sclerosis complex (TSC) — a genetic condition that causes benign tumors to grow throughout the body. In TSC, it treats kidney tumors called angiomyolipomas, brain tumors called SEGA, and seizures.
Read the rest of what Everolimus is prescribed for
In kidney transplant patients, it helps prevent the body from rejecting the new organ.
Kale has been studied for:
-
Breast cancer studied, not established Kale has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Kale for breast cancer
It is unclear if consuming kale in the diet can reduce the risk of breast cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Everolimus on your own; if you are taking Kale for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Everolimus
This page covers Kale only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Everolimus page lists 156 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 5 major · 112 moderate · 39 minor.
From our pharmacist’s overview on the Everolimus page
“Everolimus (Afinitor, Zortress, Certican) has to stay in a narrow blood-level window, whether you take it after an organ transplant or for cancer, so treat this supplement list with real caution. Most of its 156 interacting ingredients can push those levels up or down, mainly by changing how the CYP3A4 enzyme breaks the drug down.”
Reviewed by 2 · Jul 18, 2026
Taking Kale as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,971 real supplement products containing Kale, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kale. Even though Kale itself has no known interaction with Everolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Kale and Everolimus Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#116 of 1,452 supplements looked up here in the last 7 days
#741 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Kale is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kale reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Kale and Everolimus records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Kale
What is Kale?
- General nutrition and antioxidants
- Heart health support
- Eye health
- Bone health
- Digestive health and fiber
Kale is a nutrient-dense leafy green vegetable that is rich in vitamins, minerals, fiber, and antioxidants. Eaten as a normal food it is very healthy for most people, but it is a whole food rather than a proven treatment for any specific disease. People taking blood thinners or with thyroid concerns may need to be mindful of how much they eat.
Brassica oleracea var. acephala · Brassicaceae · Leaves · Fresh or cooked leaves, juice, powder, capsules, smoothies
An interaction check asks whether these two react with each other — it does not ask whether Kale is a good idea for someone in your situation. Here is what our Kale record says about it on its own.
Kale: dosing
There is no established 'dose' of kale because it is a food, not a standardized medicine. As a vegetable, it can be included as part of a balanced diet the way you would eat any leafy green.For kale powders, capsules, or juices, no proven therapeutic dose exists.
From our Kale monograph — the full record covers uses, side effects and every documented interaction.
About Everolimus
What Is Everolimus Used For?
Brand names: Certican, Afinitor, Zortress, Afinitor Disperz
Everolimus is used to treat several serious conditions. In cancer, it is prescribed for advanced hormone receptor-positive, HER2-negative breast cancer (in postmenopausal women), certain neuroendocrine tumors of the pancreas, GI tract, or lung, and advanced renal cell carcinoma (kidney cancer) when other treatments have stopped working.
It is also used for people with tuberous sclerosis complex (TSC) — a genetic condition that causes benign tumors to grow throughout the body. In TSC, it treats kidney tumors called angiomyolipomas, brain tumors called SEGA, and seizures. In kidney transplant patients, it helps prevent the body from rejecting the new organ.
Most-Reported Side Effects for Everolimus
From FAERS, the FDA’s public side-effect reporting system (50,590 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Kale
Browse every other medication we’ve checked against Kale — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Kale against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Kale list.
Kale References
The 2 sources that drive our Kale monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Kale is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Vitamin K - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
- Lutein and Zeaxanthin — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Kale and Everolimus Together: Common Questions
Is it safe to take Kale with Everolimus?
Are Kale and Everolimus used for the same thing?
Does Everolimus interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Everolimus and Kale?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.