Drug & supplement interaction

Lathyrus + Posaconazole

Posaconazole brand name: Noxafil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lathyrus and Posaconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Lathyrus and Posaconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Posaconazole and Lathyrus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lathyrus at all — not against Posaconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lathyrus safety at a glance

Lathyrus overall Use caution Heavy or prolonged intake of grass pea is linked to a serious nerve disorder called lathyrism.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Posaconazole and Lathyrus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Lathyrus Itself Has Been Linked To

This is not an interaction — nothing below involves Posaconazole. It is the side-effect record for Lathyrus on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lathyrus, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Orally, consuming a diet high in lathyrus can cause neurotoxic manifestations including muscular rigidity, spasticity, weakness, paralysis, weak pulse, shallow breathing, convulsions, or death (6,58002,58008,58009,58012,58014,58018,58021,58023,58024). Consumption of lathyrus can also result in problems with collagen crosslinking.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 58002. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
    3. 58008. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
    4. 58009. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
    5. 58012. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
    6. 58014. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed

    “When inhaled, lathyrus flour or pollen has caused allergic rhinoconjunctivitis and asthma in case reports.”

    Lathyrus · Natural Medicines adverse-effect record, reported in asthma.

    4 sources cited
    1. 58003. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
    2. 58015. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
    3. 58019. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
    4. 58031. Lieberman, P. Preventing fatalities from anaphylaxis: an allergist-immunologist's perspective. Allergy Proc 1995;16(3):109-111. PubMed
  • Seizures Worth acting on Additional detail

    “Orally, lathyrus consumption is associated with the disease lathyrism. Neurological symptoms are known as neurolathyrism. Symptoms of neurolathyrism include muscular rigidity, spasticity, weakness, paralysis of leg muscles, weak pulse, shallow breathing, convulsions, or death (6).”

    Lathyrus · Natural Medicines adverse-effect record, reported in spasticity.

    6 sources cited
    1. 58002. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
    2. 58009. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
    3. 58012. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
    4. 58014. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed
    5. 58018. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. PubMed
    6. 58024. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.

Everything above comes from the Natural Medicines adverse-effect record for Lathyrus — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Posaconazole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Posaconazole column appears here.

Special populations

Lathyrus in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Lathyrus or Posaconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lathyrus or Posaconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Posaconazole

This page covers Lathyrus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Posaconazole page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Posaconazole page

“All 17 supplements on this posaconazole (Noxafil) list interact the same basic way: they can change how much of the antifungal actually reaches your blood. Posaconazole prevents and treats dangerous fungal infections, often in people with weakened immune systems, so this is a list to take genuine care with.”

Reviewed by 2 · Jul 18, 2026

Open the Posaconazole interaction page

How much people look this up

Where Lathyrus and Posaconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lathyrus
Steady interest

#758 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Posaconazole
Steady interest

#1,742 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lathyrus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lathyrus and Posaconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lathyrus

What is Lathyrus?

  • Food and famine crop in some regions
  • Source of dietary protein
  • Traditional folk remedies
  • Animal fodder

Lathyrus most often refers to the grass pea (Lathyrus sativus), a hardy legume eaten as food in parts of Asia and Africa. While it is nutritious, heavy or prolonged consumption is linked to a serious neurological disorder called lathyrism, so it is not recommended as a dietary supplement. There is no good evidence supporting Lathyrus for any specific health condition.

Lathyrus sativus · Fabaceae · Seeds (grass pea / chickling pea); occasionally other plant parts · Dried seeds, flour, cooked legume dishes; not commonly sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether Lathyrus is a good idea for someone in your situation. Here is what our Lathyrus record says about it on its own.

Lathyrus: dosing

There is no established or standardized supplement dose for Lathyrus, and it is not recommended as a supplement. Because of the toxin it contains, larger and more frequent intake increases the risk of harm.If grass pea is part of your traditional diet, it is safest to eat it in moderation as one of many foods, and to prepare it by soaking and boiling. Do not rely on it as a main protein source.

From our Lathyrus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lathyrus monograph & all interactions
Medication

About Posaconazole

What Is Posaconazole Used For?

Brand name: Noxafil

Posaconazole is used to treat invasive aspergillosis (a serious mold infection that can spread through the body) in adults and certain pediatric patients, depending on the formulation and weight. It is also used to treat oropharyngeal candidiasis (OPC) — a yeast infection of the mouth and throat, including cases that have not responded to itraconazole and/or fluconazole — and this use is specific to the oral suspension in patients aged 13 and older.

Posaconazole is also used for prophylaxis (prevention) of invasive Aspergillus and Candida infections in people at high risk because their immune systems are severely compromised — such as stem cell transplant recipients with graft-versus-host disease (GVHD) or people with blood cancers who have low white blood cell counts from chemotherapy. The specific formulation approved for prevention varies by age and weight.

See full Posaconazole drug information
Keep checking

Other Drugs & Lathyrus

Browse every other medication we’ve checked against Lathyrus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lathyrus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lathyrus list.

See the full Lathyrus interactions page
See every supplement checked against Posaconazole, ranked by severity
Evidence & sources

Lathyrus References

The 22 references that drive our Lathyrus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587. PubMed
  3. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744. PubMed
  4. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403. PubMed
  5. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416. PubMed
  6. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322. PubMed
  7. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121. PubMed
  8. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
  9. Haimanot, R. T., Kidane, Y., Wuhib, E., Kalissa, A., Alemu, T., Zein, Z. A., and Spencer, P. S. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol. 1990;19(3):664-672. PubMed
  10. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067. PubMed
  11. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
  12. Ludolph, A. C., Hugon, J., Dwivedi, M. P., Schaumburg, H. H., and Spencer, P. S. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 1987;110 ( Pt 1):149-165. PubMed
  13. Striefler, M., Cohn, D. F., Hirano, A., and Schujman, E. The central nervous system in a case of neurolathyrism. Neurology 1977;27(12):1176-1178.
  14. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.
  15. Cohn, D. F. and Streifler, M. Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings. Arch.Toxicol.Suppl 1983;6:190-193. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lathyrus and Posaconazole Together: Common Questions

Is it safe to take Lathyrus with Posaconazole?
We do not list a known interaction between Lathyrus and Posaconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Posaconazole interact with any supplements?
Yes. Posaconazole has documented interactions with 17 supplements in our database — Lathyrus is not one of them. The Posaconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lathyrus monograph Uses, safety profile, and every drug interaction in one place Posaconazole drug information The full plain-English guide to this medication Posaconazole supplement interactions Every supplement checked against Posaconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Posaconazole and Lathyrus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.