Drug & supplement interaction

Liverwort + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Liverwort and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Liverwort and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Liverwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Liverwort at all — not against Imiquimod, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Liverwort safety at a glance

Liverwort overall Use caution The fresh plant can irritate skin and mucous membranes, and human safety data are very limited.
Pregnancy Likely Unsafe When used orally or topically. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of dried liverwort while b... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Liverwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Liverwort and Imiquimod May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Liverwort

    “Orally, fresh liverwort has been reported to cause diarrhea, gastrointestinal irritation (18), and kidney and urinary tract irritation (2). Topically, fresh liverwort has been reported to cause irritation, itching, and pustule formation known as ranunculus dermatitis (2). There is currently a limited amount of information available on the adverse effects of dried liverwort.”

    Liverwort · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    “Topically, fresh liverwort has been reported to cause irritation, itching, and pustule formation known as ranunculus dermatitis (2). In one case report, fresh liverwort was associated with contact hypersensitivity.”

    Liverwort · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 59971. Storrs, F. J., Mitchell, J. C., and Rasmussen, J. E. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686.

    Imiquimod

    Listed in the ADVERSE REACTIONS section of the FDA label for Imiquimod. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Liverwort

    “Orally, fresh liverwort has been reported to cause diarrhea and gastrointestinal irritation (18).”

    Liverwort · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Imiquimod

    Listed in the ADVERSE REACTIONS section of the FDA label for Imiquimod. Read the label on DailyMed ›

Reported for Liverwort but not commonly for Imiquimod: an allergic reaction and a skin rash.

Effects for Imiquimod come from the ADVERSE REACTIONS section of its FDA label; effects for Liverwort come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Liverwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally or topically.

Lactation Likely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of dried liverwort while breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Liverwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Liverwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Liverwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Liverwort. Even though Liverwort itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Liverwort and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Liverwort
Steady interest

#1,047 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imiquimod
Steady interest

#1,982 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Liverwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Liverwort and Imiquimod records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Liverwort

What is Liverwort?

Liverwort
  • Liver and gallbladder complaints
  • Digestive upset
  • Mild gallbladder discomfort
  • Respiratory or throat irritation
  • Skin conditions (traditional use)

Liverwort (Anemone hepatica) is a traditional herb once used for liver, gallbladder, and digestive complaints, but there is no reliable human research showing it works for any condition. The fresh plant belongs to the buttercup family and can irritate the skin and digestive tract, so it should only be used dried and with caution. Talk to your pharmacist or doctor before trying it.

Anemone hepatica · Ranunculaceae · Above-ground parts (leaves and flowers) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Liverwort is a good idea for someone in your situation. Here is what our Liverwort record says about it on its own.

Liverwort: dosing

There is no established or standardized dose for liverwort. Because it has not been studied in proper clinical trials, no safe and effective amount has been confirmed.If you choose to use a product that contains liverwort, follow the directions on the label and use only properly dried material, never the fresh plant. When in doubt, choose better-studied options with a clearer safety record.

From our Liverwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Liverwort monograph & all interactions
Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports
Fatigue 179 reports
Nausea 114 reports
Influenza like illness 102 reports
Application site erythema 100 reports
See full Imiquimod Topical drug information
Keep checking

Other Drugs & Liverwort

Browse every other medication we’ve checked against Liverwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Liverwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Liverwort list.

See the full Liverwort interactions page
See every supplement checked against Imiquimod, ranked by severity
Evidence & sources

Liverwort References

The 3 references that drive our Liverwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Storrs, F. J., Mitchell, J. C., and Rasmussen, J. E. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Liverwort and Imiquimod Together: Common Questions

Is it safe to take Liverwort with Imiquimod?
We do not list a known interaction between Liverwort and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Liverwort and Imiquimod have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Imiquimod interact with any supplements?
Yes. Imiquimod has documented interactions with 3 supplements in our database — Liverwort is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Liverwort monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Liverwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.