Drug & supplement interaction

Lobelia + Galantamine

Galantamine brand names: Reminyl, Razadyne.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lobelia and Galantamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Galantamine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lobelia and Galantamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Galantamine and Lobelia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lobelia safety at a glance

Lobelia overall Use caution Lobelia can be toxic and cause serious effects at higher doses, so caution is strongly advised.
Pregnancy Likely Unsafe When used orally due to its emetic effects. There is insufficient reliable information available about the safety of lobelia when used topically during pregnanc... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally due to its emetic effects. There is insufficient reliable information available about the safety of lobelia when used topically during pregnanc... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Galantamine and Lobelia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Galantamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Galantamine is filed under 5 classifications — including acetylcholinesterase (ache) inhibitors, cholinergic drugs, cytochrome p450 2d6 (cyp2d6) substrates. Lobelia has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Galantamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lobelia Does Interact With Other Medications

Lobelia has 1 moderate known drug interaction in our database — Galantamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Galantamine)
Taking anything else?

Check Another of Your Medications Against Lobelia

Covers the 2,830 medications we’ve checked against Lobelia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lobelia and Galantamine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness Additional detail

    Lobelia

    “Orally, lobelia can cause nausea, vomiting, diarrhea, coughing, dizziness, tremors, and throat irritation. These adverse effects have been reported with doses as low as 50 mg (4,16414). Lobelia leaf can cause toxicity when taken in doses of 600 mg or higher. Symptoms of lobelia toxicity include sweating, tachycardia, convulsions, hypothermia, hypotension, coma, and death (4,11).”

    Lobelia · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 16414. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
    3. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    “Orally, lobelia can cause dizziness and tremors. High doses of lobelia leaf can cause toxicity. Symptoms of lobelia toxicity include convulsions, coma, and death (4,11).”

    Lobelia · Natural Medicines adverse-effect record, reported in vertigo.

    2 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Galantamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Galantamine. Read the label on DailyMed ›

  • Diarrhea / Vomiting / Nausea Additional detail

    Lobelia

    “Orally, lobelia can cause nausea, vomiting, diarrhea, and throat irritation (4,16414).”

    Lobelia · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 16414. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed

    Galantamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Galantamine. Read the label on DailyMed ›

Reported for Lobelia but not commonly for Galantamine: sore throat, seizures, a fast or pounding heartbeat and low blood pressure.

Effects for Galantamine come from the ADVERSE REACTIONS section of its FDA label; effects for Lobelia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,188 voluntary FDA FAERS reports for Galantamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lobelia in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally due to its emetic effects. There is insufficient reliable information available about the safety of lobelia when used topically during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Galantamine Products Have a Food Rule — Lobelia Should Not Break It

At least one FDA label for a product containing Galantamine says to take it with food. If you take Lobelia on an empty stomach out of habit, keep them separate — and take Galantamine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Galantamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Take with food; ensure adequate fluid intake during treatment (2.1) Hepatic impairment: should not exceed 16 mg/day for moderate hepatic impairment; do not use in patients with severe hepatic impairment ( 2.2 ) Renal impairment: should not exceed 16 mg/day for creatinine clearance 9 to 59 mL/min; do not use in patients with creatinine clearance less than 9 mL/min.

From the Dosage and Administration section of the FDA label we read for Galantamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Galantamine

This page covers Lobelia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Galantamine page lists 170 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 126 moderate · 41 minor.

From our pharmacist’s overview on the Galantamine page

“Galantamine (Razadyne) treats Alzheimer's disease, so it is often a caregiver filling the pill organizer alongside memory supplements and morning juice. That pairing deserves genuine care, because three of the 170 supplement ingredients on file are rated major and two of them are everyday items.”

Reviewed by 2 · Jul 18, 2026

Open the Galantamine interaction page

One more smart check

Taking Lobelia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 482 real supplement products containing Lobelia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lobelia. Even though Lobelia itself has no known interaction with Galantamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lobelia and Galantamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lobelia
Top 25%

#329 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Galantamine
Top half

#993 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lobelia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lobelia and Galantamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lobelia

What is Lobelia?

  • Asthma and breathing problems
  • Cough and bronchitis
  • Smoking cessation aid
  • Muscle relaxation

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, causing serious side effects, so it should be used with great caution and only under professional guidance.

Lobelia inflata · Campanulaceae · Dried aerial parts (leaves, stems, flowers, and seeds) · Capsules, tinctures, liquid extracts, teas, and dried herb

An interaction check asks whether these two react with each other — it does not ask whether Lobelia is a good idea for someone in your situation. Here is what our Lobelia record says about it on its own.

Lobelia: dosing

There is no well-established or standardized safe dose of lobelia. Because the plant can be toxic, the amount that helps and the amount that harms may be close together.If a product is used, follow the directions on the label carefully and do not exceed them. We do not recommend self-dosing this herb without professional guidance.

From our Lobelia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lobelia monograph & all interactions
Medication

About Galantamine

What Is Galantamine Used For?

Brand names: Reminyl, Razadyne

Galantamine — available as extended-release capsules, tablets, and an oral solution — is used to treat mild to moderate dementia caused by Alzheimer's disease. All supported formulations share this indication.

It does not cure or slow the underlying disease, but it can help support cognitive function in people with early to moderate-stage Alzheimer's. Its benefits may lessen as the disease progresses and more brain cells are lost.

Most-Reported Side Effects for Galantamine

From FAERS, the FDA’s public side-effect reporting system (3,188 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 812 reports
Cognitive disorder 664 reports
Constipation 651 reports
Balance disorder 632 reports
Hypotension 631 reports
See full Galantamine drug information
Keep checking

Other Drugs & Lobelia

Browse every other medication we’ve checked against Lobelia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Lobelia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Lobelia list.

See the full Lobelia interactions page
See every supplement checked against Galantamine, ranked by severity
Evidence & sources

Lobelia References

The 6 references that drive our Lobelia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lobelia and Galantamine Together: Common Questions

Is it safe to take Lobelia with Galantamine?
We do not list a known interaction between Lobelia and Galantamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lobelia and Galantamine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Lobelia and Galantamine at the same time of day?
At least one FDA label for a product containing Galantamine says to take it with food. If you take Lobelia on an empty stomach out of habit, keep them separate and take Galantamine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Galantamine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Lobelia and Galantamine combination checked?
Interactions in our licensed database are recorded against drug classes. Galantamine is filed under 5 classifications, and Lobelia has documented interactions with 1 drug class — none of Galantamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lobelia interact with any other medications?
Yes. Lobelia has 1 documented drug interaction in our database — Galantamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Galantamine interact with any supplements?
Yes. Galantamine has documented interactions with 170 supplements in our database — Lobelia is not one of them. The Galantamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lobelia monograph Uses, safety profile, and every drug interaction in one place Galantamine drug information The full plain-English guide to this medication Galantamine supplement interactions Every supplement checked against Galantamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Galantamine and Lobelia?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.