Drug & supplement interaction

Maple Syrup Diet + Setmelanotide

Setmelanotide brand name: Imcivree.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Maple Syrup Diet and Setmelanotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Maple Syrup Diet and Setmelanotide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Setmelanotide and Maple Syrup Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Maple Syrup Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Maple Syrup Diet at all — not against Setmelanotide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Maple Syrup Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maple Syrup Diet safety at a glance

Maple Syrup Diet overall Use caution It is a very-low-nutrient liquid fast that can cause nutrient deficiencies and other problems, especially if done for more than a day or two.
Pregnancy Possibly Unsafe During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term... Read the full pregnancy detail
Breastfeeding Possibly Unsafe During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Setmelanotide and Maple Syrup Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Maple Syrup Diet Itself Has Been Linked To

This is not an interaction — nothing below involves Setmelanotide. It is the side-effect record for Maple Syrup Diet on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Maple Syrup Diet, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on Additional detail

    “There is limited reliable information available about the adverse effects of the maple syrup diet. However, the maple syrup diet does not provide adequate nutrition and involves the consumption of large quantities of water. This can lead to electrolyte imbalances when used short-term and malnutrition when used long-term.”

    Maple Syrup Diet · Natural Medicines adverse-effect record, reported in malnutrition.

    1 source cited
    1. 103181. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.

Everything above comes from the Natural Medicines adverse-effect record for Maple Syrup Diet — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Setmelanotide’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Setmelanotide column appears here.

Special populations

Maple Syrup Diet in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

During pregnancy and lactation. The maple syrup diet is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as well as malnutrition when used long-term.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Setmelanotide Is Prescribed For, and What Maple Syrup Diet Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Setmelanotide is a prescription medicine with approved uses on its FDA label. Maple Syrup Diet is an eating pattern: what follows is what researchers have looked at it for, and how strong that evidence is.

Setmelanotide is prescribed for: Imcivree is used to reduce excess body weight and maintain that weight loss long-term in adults and children with certain rare, specific causes of obesity. It is not intended for general weight loss or common obesity. Imcivree is approved for: acquired hypothalamic obesity (HO) in patients aged 4 and older; Bardet-Biedl syndrome (BBS) in patients aged 2 and older; and obesity caused by confirmed deficiencies of POMC, PCSK1, or LEPR genes (pathogenic, likely pathogenic, or uncertain-significance variants) in patients aged 2 and older.

Maple Syrup Diet has been studied for:

  • Obesity studied, not established Maple Syrup Diet has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Maple Syrup Diet for obesity

    Clinical research in overweight Korean women shows that following the maple syrup diet for 7 days improves body mass index, body fat percentage, and waist-hip ratio when compared with a control group following a normal diet. Women who followed the maple syrup diet using a lemon-flavored liquid in place of lemon juice experienced similar improvements to those using lemon juice.

    1 source cited
    1. 103140. Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH. Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women. Nutr Res. 2015 May;35(5):409-20. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Setmelanotide on your own; if you are taking Maple Syrup Diet for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

How much people look this up

Where Maple Syrup Diet and Setmelanotide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maple Syrup Diet
Steady interest

#1,238 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Setmelanotide
Top half

#980 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maple Syrup Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Maple Syrup Diet and Setmelanotide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Maple Syrup Diet

What is Maple Syrup Diet?

  • Short-term weight loss
  • Body 'detox' or cleanse
  • Jump-starting a diet
  • Quick fasting program

The Maple Syrup Diet (also called the Master Cleanse or Lemonade Diet) is a fad cleanse where you drink a maple syrup, lemon, water, and cayenne mixture instead of eating food for several days. There is no good scientific evidence that it 'detoxes' the body, and any weight lost is mostly water and is usually regained. It can be risky because it provides almost no protein, fat, vitamins, or minerals, so most people should avoid it.

Liquid cleanse drink (a mix of maple syrup, lemon juice, water, and cayenne pepper)

An interaction check asks whether these two react with each other — it does not ask whether Maple Syrup Diet is a good idea for someone in your situation. Here is what our Maple Syrup Diet record says about it on its own.

Maple Syrup Diet: dosing

There is no medically established or recommended dose for the Maple Syrup Diet, because it is a fad cleanse rather than a proven treatment. Popular versions have people drink several glasses of the maple-lemon-cayenne mixture throughout the day in place of meals.Health experts generally do not recommend this diet at all. A balanced, calorie-controlled eating plan is a far safer and more effective way to lose weight.

From our Maple Syrup Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maple Syrup Diet monograph & all interactions
Medication

About Setmelanotide Injection

What Is Setmelanotide Injection Used For?

Brand name: Imcivree

Imcivree is used to reduce excess body weight and maintain that weight loss long-term in adults and children with certain rare, specific causes of obesity. It is not intended for general weight loss or common obesity.

Imcivree is approved for: acquired hypothalamic obesity (HO) in patients aged 4 and older; Bardet-Biedl syndrome (BBS) in patients aged 2 and older; and obesity caused by confirmed deficiencies of POMC, PCSK1, or LEPR genes (pathogenic, likely pathogenic, or uncertain-significance variants) in patients aged 2 and older.

See full Setmelanotide Injection drug information
Keep checking

Other Drugs & Maple Syrup Diet

Browse every other medication we’ve checked against Maple Syrup Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Maple Syrup Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Maple Syrup Diet list.

See the full Maple Syrup Diet interactions page
See every supplement checked against Setmelanotide, ranked by severity
Evidence & sources

Maple Syrup Diet References

The 2 references that drive our Maple Syrup Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH. Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women. Nutr Res. 2015 May;35(5):409-20. PubMed
  2. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Maple Syrup Diet While Taking Setmelanotide: Common Questions

Is it safe to follow Maple Syrup Diet while taking Setmelanotide?
We do not list a known interaction between Maple Syrup Diet and Setmelanotide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Maple Syrup Diet and Setmelanotide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Maple Syrup Diet in each. That is a conversation for your prescriber, especially if Setmelanotide is being adjusted to a target.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maple Syrup Diet monograph Uses, safety profile, and every drug interaction in one place Setmelanotide Injection drug information The full plain-English guide to this medication Setmelanotide supplement interactions Every supplement checked against Setmelanotide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Setmelanotide and Maple Syrup Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.