Drug & supplement interaction

Methasterone + Apraclonidine

Apraclonidine brand name: Iopidine.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Methasterone and Apraclonidine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Methasterone and Apraclonidine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Apraclonidine and Methasterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Methasterone at all — not against Apraclonidine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Methasterone safety at a glance

Methasterone overall Avoid Methasterone is a controlled anabolic steroid linked to serious liver injury and is not a legitimate dietary supplement.
Pregnancy Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Apraclonidine and Methasterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Apraclonidine’s Own FDA Label Lists

This is not an interaction — none of it involves Methasterone. These are the most notable effects listed in the ADVERSE REACTIONS section of Apraclonidine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Wheezing Worth acting on
  • An irregular heartbeat Worth acting on
  • Shortness of breath Worth acting on mentioned in 4.7% of FDA reports for Apraclonidine
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • An allergic reaction Worth acting on
  • Dry eyes
  • Blurred vision mentioned in 5.7% of FDA reports for Apraclonidine
  • Dry mouth mentioned in 4.7% of FDA reports for Apraclonidine

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Apraclonidine. Read the label on DailyMed › Where a percentage is shown, it is the share of 106 voluntary FDA FAERS reports for Apraclonidine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Methasterone’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Methasterone side to compare — that is a limit of the record, not a statement that Methasterone has no side effects.

Special populations

Methasterone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Apraclonidine

This page covers Methasterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apraclonidine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Butcher's Broom (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Apraclonidine page

“Apraclonidine (Iopidine) is an eye drop that lowers pressure inside the eye, most often around laser procedures, and its interaction list deserves a careful read rather than a shrug. Of the 18 supplement and herbal ingredients on file, only one rates major, and that one is activated charcoal, which binds many drugs and can reduce their…”

Reviewed by 2 · Jul 18, 2026

Open the Apraclonidine interaction page

How much people look this up

Where Methasterone and Apraclonidine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Methasterone
Steady interest

#835 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Apraclonidine
Steady interest

#2,605 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methasterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Methasterone and Apraclonidine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Methasterone

What is Methasterone?

  • Muscle building
  • Athletic performance
  • Strength gains
  • Body recomposition

Methasterone (also called methyldrostanolone or 'Superdrol') is a synthetic, oral anabolic steroid — not a dietary supplement, herb, or natural product. It is a controlled substance in the United States and has been linked to serious liver damage and other harms, so it should not be used outside of legitimate medical or research settings.

Synthetic compound (not derived from a plant) · Oral capsules or tablets (illicit/gray-market products)

An interaction check asks whether these two react with each other — it does not ask whether Methasterone is a good idea for someone in your situation. Here is what our Methasterone record says about it on its own.

Methasterone: dosing

There is no safe or medically established dose for methasterone. It is not an approved medicine or legitimate supplement, and we will not provide dosing guidance for it.Because of its serious risks and its status as a controlled substance, the safest amount is none.

From our Methasterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Methasterone monograph & all interactions
Medication

About Apraclonidine Ophthalmic

What Is Apraclonidine Ophthalmic Used For?

Brand name: Iopidine

Apraclonidine ophthalmic solution 0.5% is indicated as a short-term add-on therapy for patients with glaucoma who are already on the maximum tolerated medical treatment but still need additional reduction in intraocular pressure (IOP — the pressure inside the eye). It may be used to help delay the need for surgery while other options are explored.

It's worth knowing that if you're already using two aqueous-suppressing drugs (medicines that reduce fluid production in the eye) — such as a beta-blocker combined with a carbonic anhydrase inhibitor — adding apraclonidine may not provide much additional benefit, since it works by the same mechanism.

Most-Reported Side Effects for Apraclonidine

From FAERS, the FDA’s public side-effect reporting system (106 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Somnolence 7 reports
Eyelid ptosis 6 reports
Vision blurred 6 reports
Constipation 5 reports
Dry mouth 5 reports
See full Apraclonidine Ophthalmic drug information
Keep checking

Other Drugs & Methasterone

Browse every other medication we’ve checked against Methasterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Methasterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methasterone list.

See the full Methasterone interactions page
See every supplement checked against Apraclonidine, ranked by severity
Evidence & sources

Methasterone References

The 1 references that drive our Methasterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Methasterone and Apraclonidine Together: Common Questions

Is it safe to take Methasterone with Apraclonidine?
We do not list a known interaction between Methasterone and Apraclonidine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Apraclonidine interact with any supplements?
Yes. Apraclonidine has documented interactions with 18 supplements in our database — Methasterone is not one of them. The Apraclonidine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Methasterone monograph Uses, safety profile, and every drug interaction in one place Apraclonidine Ophthalmic drug information The full plain-English guide to this medication Apraclonidine supplement interactions Every supplement checked against Apraclonidine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Apraclonidine and Methasterone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.