Methylsulfonylmethane (msm) + Mexiletine
Mexiletine brand name: Mexitil.
We found no known interaction between Methylsulfonylmethane (msm) and Mexiletine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mexiletine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Methylsulfonylmethane (msm) and Mexiletine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Mexiletine and Methylsulfonylmethane (msm) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Methylsulfonylmethane (msm) at all — not against Mexiletine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Methylsulfonylmethane (msm) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Mexiletine Products Have a Food Rule — Methylsulfonylmethane (msm) Should Not Break It
At least one FDA label for a product containing Mexiletine says to take it with food. If you take Methylsulfonylmethane (msm) on an empty stomach out of habit, keep them separate — and take Mexiletine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mexiletine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administration with food or antacid is recommended.
From the Dosage and Administration section of the FDA label we read for Mexiletine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Mexiletine
This page covers Methylsulfonylmethane (msm) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mexiletine page lists 152 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).
By severity: 1 major · 107 moderate · 44 minor.
From our pharmacist’s overview on the Mexiletine page
“Mexiletine (Mexitil) steadies the heart's rhythm, and its benefit depends on holding a fairly precise blood level, so the 152 supplements on this list deserve real attention rather than a shrug. Only one entry, activated charcoal, is rated major, because it can soak up the drug in the gut and cut how much actually reaches your bloodstr…”
Reviewed by 2 · Jul 18, 2026
Where Methylsulfonylmethane (msm) and Mexiletine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#689 of 1,452 supplements looked up here in the last 7 days
#1,396 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylsulfonylmethane (msm) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Methylsulfonylmethane (msm) and Mexiletine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Methylsulfonylmethane (msm)
What is Methylsulfonylmethane (msm)?
- Osteoarthritis and joint pain
- Muscle soreness after exercise
- Inflammation
- Skin and hair health
- Allergy symptoms
Methylsulfonylmethane (MSM) is a natural sulfur compound that people most often take for joint pain and exercise recovery. Some early research suggests it may modestly help osteoarthritis symptoms, but the evidence is limited and more study is needed. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before starting it.
Not applicable (a sulfur-containing compound) · Capsules, tablets, powders, creams, and combination joint supplements
An interaction check asks whether these two react with each other — it does not ask whether Methylsulfonylmethane (msm) is a good idea for someone in your situation. Here is what our Methylsulfonylmethane (msm) record says about it on its own.
Methylsulfonylmethane (msm): dosing
There is no official or standardized dose of MSM. Studies have used a wide range of amounts, and the best dose is not clearly established.The safest approach is to follow the directions on the product label and not take more than recommended. They can help you decide if it is appropriate and what amount is reasonable.
From our Methylsulfonylmethane (msm) monograph — the full record covers uses, side effects and every documented interaction.
About Mexiletine
What Is Mexiletine Used For?
Brand name: Mexitil
Mexiletine Hydrochloride capsules are indicated for the treatment of documented, life-threatening ventricular arrhythmias — for example, sustained ventricular tachycardia (a dangerously fast heart rhythm originating in the lower chambers). Because mexiletine itself can trigger arrhythmias, it is not recommended for minor or symptom-free irregular heartbeats.
Treatment is started in a hospital setting so heart rhythm can be monitored closely. Antiarrhythmic drugs, including mexiletine, have not been shown to improve overall survival in patients with ventricular arrhythmias.
Other Drugs & Methylsulfonylmethane (msm)
Browse every other medication we’ve checked against Methylsulfonylmethane (msm) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Methylsulfonylmethane (msm) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methylsulfonylmethane (msm) list.
Methylsulfonylmethane (msm) References
The 4 references that drive our Methylsulfonylmethane (msm) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed
- Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. PubMed
- Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94. PubMed
- Hwang JC, Khine KT, Lee JC, Boyer DS, Francis BA. Methyl-sulfonyl-methane (MSM)-induced acute angle closure. J Glaucoma. 2015 Apr-May;24(4):e28-30. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Methylsulfonylmethane (msm) and Mexiletine Together: Common Questions
Is it safe to take Methylsulfonylmethane (msm) with Mexiletine?
Do Methylsulfonylmethane (msm) and Mexiletine have any of the same side effects?
Should I take Methylsulfonylmethane (msm) and Mexiletine at the same time of day?
Does Mexiletine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.