Drug & supplement interaction

Oriental Arborvitae + Penicillamine

Penicillamine brand names: Cuprimine, Depen Titratable.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Oriental Arborvitae and Penicillamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Penicillamine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Oriental Arborvitae and Penicillamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Penicillamine and Oriental Arborvitae in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Oriental Arborvitae at all — not against Penicillamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Oriental Arborvitae safety at a glance

Oriental Arborvita... overall Use caution Some plant parts and oils can be toxic, and human safety data are limited.
Pregnancy Possibly Unsafe When the leafy twig is used orally during pregnancy. Oriental arborvitae contains thujone. Thujone might stimulate uterine activity; avoid using. There is insuf... Read the full pregnancy detail
Breastfeeding Avoid No reliable safety information, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Penicillamine and Oriental Arborvitae? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Oriental Arborvitae and Penicillamine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    Oriental Arborvitae

    “Orally, taking oriental arborvitae long-term or at high doses might cause adverse effects due to the thujone constituent. Thujone-containing herbs can cause restlessness, vomiting, dizziness, tremors, kidney damage, hallucinations, and convulsions when used long-term or at high doses. Thujone intoxication can cause psychoactivity similar to tetrahydrocannibinol, the active constituent in marijuana. (12).”

    Oriental Arborvitae · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Oriental Arborvitae

    Recorded for Oriental Arborvitae in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed ›

  • Vomiting Additional detail

    Oriental Arborvitae

    “Orally, thujone-containing herbs such as oriental arborvitae may cause vomiting when used long-term or at high doses (12).”

    Oriental Arborvitae · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed ›

Reported for Oriental Arborvitae but not commonly for Penicillamine: hallucinations, seizures and dizziness.

Effects for Penicillamine come from the ADVERSE REACTIONS section of its FDA label; effects for Oriental Arborvitae come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 917 voluntary FDA FAERS reports for Penicillamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Oriental Arborvitae in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When the leafy twig is used orally during pregnancy. Oriental arborvitae contains thujone. Thujone might stimulate uterine activity; avoid using. There is insufficient reliable information available about the safety of oriental arborvitae when used topically during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Penicillamine Products Have a Food Rule — Oriental Arborvitae Should Not Break It

At least one FDA label for a product containing Penicillamine says to take it on an empty stomach. Most supplements — Oriental Arborvitae included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Penicillamine on its own and move Oriental Arborvitae to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Penicillamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION In all patients receiving penicillamine, it is important that CUPRIMINE be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk.

From the Dosage and Administration section of the FDA label we read for Penicillamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Penicillamine

This page covers Oriental Arborvitae only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Penicillamine page lists 26 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Coffee Charcoal (moderate).

By severity: 3 major · 13 moderate · 10 minor.

From our pharmacist’s overview on the Penicillamine page

“People take penicillamine (Cuprimine, Depen) for demanding conditions, Wilson's disease, rheumatoid arthritis, cystinuria, and its 26 supplement interactions are not a list to skim, three of them rated major. Seventeen ingredients can keep an oral dose from being fully absorbed, activated charcoal chief among them, and six more can str…”

Reviewed by 2 · Jul 18, 2026

Open the Penicillamine interaction page

One more smart check

Taking Oriental Arborvitae as Part of a Dietary Supplement Product? Check It for Interactions

We hold 76 real supplement products containing Oriental Arborvitae, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oriental Arborvitae. Even though Oriental Arborvitae itself has no known interaction with Penicillamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oriental Arborvitae and Penicillamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oriental Arborvitae
Steady interest

#1,096 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Penicillamine
Steady interest

#2,338 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Oriental Arborvitae reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Oriental Arborvitae and Penicillamine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Oriental Arborvitae

What is Oriental Arborvitae?

Oriental Arborvitae
  • Insomnia and restlessness
  • Constipation (seeds)
  • Hair loss and scalp health (topical)
  • Bleeding and heavy menstruation (traditional)
  • Cough and respiratory complaints

Oriental Arborvitae is an evergreen conifer used in Traditional Chinese Medicine, where the seeds (Bai Zi Ren) are taken to calm the mind and ease constipation, and the leaves (Ce Bai Ye) are used for bleeding and hair loss. Solid human evidence for these uses is limited, and parts of the plant can be toxic if misused. Talk with a pharmacist or doctor before trying it, and avoid it in pregnancy.

Platycladus orientalis · Cupressaceae · Seeds (Bai Zi Ren) and leaves/twigs (Ce Bai Ye) · Dried seeds, dried leaf, decoctions (teas), powders, capsules, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Oriental Arborvitae is a good idea for someone in your situation. Here is what our Oriental Arborvitae record says about it on its own.

Oriental Arborvitae: dosing

There is no well-established standardized dose for Oriental Arborvitae as a supplement. In Traditional Chinese Medicine, the seeds and leaves are used in specific amounts within formulas prepared by a trained practitioner, and the right amount depends on the part used and the preparation.If you choose to use a commercial product, follow the directions on the label and do not exceed them. Never ingest the concentrated essential oil unless directed by a qualified professional.

From our Oriental Arborvitae monograph — the full record covers uses, side effects and every documented interaction.

Read the full Oriental Arborvitae monograph & all interactions
Medication

About Penicillamine

What Is Penicillamine Used For?

Brand names: Cuprimine, Depen Titratable

Penicillamine is used for three distinct conditions. It treats Wilson's disease — a rare genetic disorder in which the body accumulates dangerous levels of copper — by binding to the excess copper and helping the body remove it. It also treats cystinuria, a condition where the amino acid cystine builds up and forms painful kidney stones, by converting cystine into a more soluble form that the body can excrete more easily.

For patients with severe, active rheumatoid arthritis who have not responded adequately to conventional therapies, penicillamine (available as Aagylur, Cuprimine, Depen, and other products) may be used to help suppress disease activity and reduce joint pain, tenderness, and swelling.

See full Penicillamine drug information
Keep checking

Other Drugs & Oriental Arborvitae

Browse every other medication we’ve checked against Oriental Arborvitae — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Oriental Arborvitae against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Oriental Arborvitae list.

See the full Oriental Arborvitae interactions page
See every supplement checked against Penicillamine, ranked by severity
Evidence & sources

Oriental Arborvitae References

The 2 references that drive our Oriental Arborvitae monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Oriental Arborvitae and Penicillamine Together: Common Questions

Is it safe to take Oriental Arborvitae with Penicillamine?
We do not list a known interaction between Oriental Arborvitae and Penicillamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Oriental Arborvitae and Penicillamine have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Oriental Arborvitae and Penicillamine at the same time of day?
At least one FDA label for a product containing Penicillamine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Penicillamine on its own and move Oriental Arborvitae to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Penicillamine interact with any supplements?
Yes. Penicillamine has documented interactions with 26 supplements in our database — Oriental Arborvitae is not one of them. The Penicillamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Oriental Arborvitae monograph Uses, safety profile, and every drug interaction in one place Penicillamine drug information The full plain-English guide to this medication Penicillamine supplement interactions Every supplement checked against Penicillamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Penicillamine and Oriental Arborvitae?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.