Ornithine + Metoclopramide Hydrochloride
Metoclopramide Hydrochloride brand name: Gimoti.
We found no known interaction between Ornithine and Metoclopramide Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Ornithine and Metoclopramide Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Metoclopramide Hydrochloride and Ornithine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Ornithine at all — not against Metoclopramide Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ornithine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Metoclopramide Hydrochloride
This page covers Ornithine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoclopramide Hydrochloride page lists 135 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major), Kava (major) and L-tryptophan (major).
By severity: 7 major · 114 moderate · 14 minor.
From our pharmacist’s overview on the Metoclopramide Hydrochloride page
“Metoclopramide (Gimoti, also sold as Reglan) calms nausea and speeds a slow stomach by acting on the brain, and that is exactly where most of these 135 supplements and herbs collide with it. This is a list to treat with genuine care.”
Reviewed by 2 · Jul 18, 2026
Taking Ornithine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 751 real supplement products containing Ornithine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ornithine. Even though Ornithine itself has no known interaction with Metoclopramide Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ornithine and Metoclopramide Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#261 of 1,452 supplements looked up here in the last 7 days
#823 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Ornithine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ornithine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ornithine and Metoclopramide Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ornithine
What is Ornithine?
- Athletic performance and recovery
- Reducing fatigue
- Sleep and stress support
- Liver and ammonia metabolism support
- Wound healing
Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep, but human evidence is limited and mixed. Talk to your pharmacist or doctor before using it, especially if you have a medical condition.
Amino acid (not a plant part) · Capsules, tablets, powder, often as L-ornithine or ornithine alpha-ketoglutarate (OKG)
An interaction check asks whether these two react with each other — it does not ask whether Ornithine is a good idea for someone in your situation. Here is what our Ornithine record says about it on its own.
Ornithine: dosing
There is no official, standardized dose of ornithine for any supplement use. Amounts used in studies have varied widely, and there is not enough strong evidence to recommend a specific dose.The safest approach is to follow the directions on the product label and not exceed them.
From our Ornithine monograph — the full record covers uses, side effects and every documented interaction.
About Metoclopramide Nasal Spray
What Is Metoclopramide Nasal Spray Used For?
Brand name: Gimoti
Gimoti (metoclopramide nasal spray) is approved for adults with acute and recurrent diabetic gastroparesis — a condition where diabetes damages the nerves controlling stomach emptying, causing nausea, vomiting, and bloating. It works to relieve those symptoms by helping the stomach empty more normally.
Gimoti is not recommended for children, or for adults with moderate to severe kidney or liver disease. It is also not recommended for adults taking strong CYP2D6 inhibitor medications (certain antidepressants and other drugs that slow how the body breaks down metoclopramide).
Most-Reported Side Effects for Metoclopramide Hydrochloride
From FAERS, the FDA’s public side-effect reporting system (76,710 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Ornithine
Browse every other medication we’ve checked against Ornithine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Ornithine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ornithine list.
Ornithine References
The 1 sources that drive our Ornithine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Ornithine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ornithine and Metoclopramide Hydrochloride Together: Common Questions
Is it safe to take Ornithine with Metoclopramide Hydrochloride?
Does Metoclopramide Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Metoclopramide Hydrochloride and Ornithine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.