Drug & supplement interaction

Orris + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide brand names: Coricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorpheniramine Maleate, Dextromethorphan Hydrobromide and Orris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Orris at all — not against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Orris safety at a glance

Orris overall Use caution Mostly used as a fragrance; the fresh root can irritate the skin and gut and human safety data for internal use are limited.

Pregnancy Avoid Not enough safety information; avoid medicinal use during pregnancy.

Breastfeeding Avoid Not enough safety information; avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorpheniramine Maleate, Dextromethorphan Hydrobromide and Orris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Orris Itself Has Been Linked To

This is not an interaction — nothing below involves Chlorpheniramine Maleate, Dextromethorphan Hydrobromide. It is the side-effect record for Orris on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Orris, this list is the first place to look.

Stomach pain / Diarrhea / Vomiting Additional detail
“Orally, the fresh plant juice or root can cause severe mucosal irritation, abdominal pain, vomiting, and bloody diarrhea (18).”

Orris · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
A skin rash Additional detail
“Topically, the fresh plant juice or root can cause severe skin and mucosal irritation (12,18). A case of allergic contact dermatitis has been reported in a 45-year-old atopic patient using a facial cream containing an extract of orris root.”

Orris · Natural Medicines adverse-effect record, reported in dermatitis.
3 sources cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

106685. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

Everything above comes from the Natural Medicines adverse-effect record for Orris — expand a row for the licensed statement it rests on. We haven’t matched Chlorpheniramine Maleate, Dextromethorphan Hydrobromide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Chlorpheniramine Maleate, Dextromethorphan Hydrobromide.

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

This page covers Orris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine Maleate, Dextromethorphan Hydrobromide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Lithium (major) and Scopolia (major).

By severity: 6 major · 170 moderate · 42 minor.

From our pharmacist’s overview on the Chlorpheniramine Maleate, Dextromethorphan Hydrobromide page

“Grapefruit is the interaction I would flag first for anyone taking chlorpheniramine with dextromethorphan (Coricidin HBP Cough & Cold). It blocks the enzyme that clears these ingredients, so levels and side effects can climb.”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interaction page

One more smart check

Taking Orris as Part of a Dietary Supplement Product? Check It for Interactions

We hold 36 real supplement products containing Orris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orris. Even though Orris itself has no known interaction with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Orris

Steady interest

#1,046 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

Top half

#887 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orris reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Orris

What is Orris?

Fragrance and flavoring (perfumes, gin, cosmetics)
Traditional remedy for coughs and congestion
Skin and breath freshening
Teething soothers for infants (traditional, not recommended)
Digestive complaints (traditional use)

Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very little reliable human evidence that it treats any medical condition, and the fresh root can be irritating, so it is best thought of as a fragrance ingredient rather than a remedy. Talk to your pharmacist or doctor before using it for any health purpose.

Iris germanica · Iridaceae · Dried rhizome (orris root) and its essential oil/extract (orris butter) · Dried root pieces, powder, essential oil (orris butter), tinctures, and as a flavoring or fragrance ingredient

An interaction check asks whether these two react with each other — it does not ask whether Orris is a good idea for someone in your situation. Here is what our Orris record says about it on its own.

Orris: dosing

There is no established or standardized medicinal dose for orris root. Its main everyday uses—as a perfume ingredient or a flavoring—involve very small amounts and are not the same as taking it as a supplement.If you are considering a product that contains orris, follow the directions on the label and do not exceed them.

From our Orris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Orris monograph & all interactions

Keep checking

Other Drugs & Orris

Browse every other medication we’ve checked against Orris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Orris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orris list.

See the full Orris interactions page

See every supplement checked against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, ranked by severity

Evidence & sources

Orris References

The 3 references that drive our Orris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide Together: Common Questions

Is it safe to take Orris with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

We do not list a known interaction between Orris and Chlorpheniramine Maleate, Dextromethorphan Hydrobromide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interact with any supplements?

Yes. Chlorpheniramine Maleate, Dextromethorphan Hydrobromide has documented interactions with 218 supplements in our database — Orris is not one of them. The Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Orris monograph Uses, safety profile, and every drug interaction in one place Chlorpheniramine Maleate, Dextromethorphan Hydrobromide supplement interactions Every supplement checked against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorpheniramine Maleate, Dextromethorphan Hydrobromide and Orris?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.