Medication interaction hub

What Supplements Interact with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide brand names: Coricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief. Every interaction below applies to the brands too.

218 Interactions 6 Major 170 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine Maleate, Dextromethorphan Hydrobromide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the interaction I would flag first for anyone taking chlorpheniramine with dextromethorphan (Coricidin HBP Cough & Cold). It blocks the enzyme that clears these ingredients, so levels and side effects can climb. That same enzyme pathway runs through over half of the 218 supplements and herbs listed, and with six rated major, this medicine deserves genuine care before mixing in anything herbal. St. John's wort pulls the opposite way, speeding the drug's breakdown so it works less well.

Roughly 30 herbs also share the antihistamine's anticholinergic effects, piling on dry mouth, blurred vision, and confusion, while a serotonergic cluster raises the risk of serotonin syndrome, a dangerous excess of serotonin activity, alongside dextromethorphan. Fibers and charcoal products can blunt absorption of any oral dose, so space them well apart. Most of the 170 moderate and 42 minor entries echo these themes with less force.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 170 Minor 42 No known interaction 1,234

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide: Top Interactions at a Glance

The most significant Chlorpheniramine Maleate, Dextromethorphan Hydrobromide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 218 interacting ingredients — plus 1,234 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Chlorpheniramine Maleate, Dextromethorphan Hydrobromide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Henbane + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Lithium + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction Major Likelihood Probable Scopolia + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction Major Likelihood Probable St. John's Wort + Chlorpheniramine Maleate, Dextromethorphan Hydrobromidei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

All 1,452 ingredients in our database, ranked by severity — 218 with a Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interaction on file and 1,234 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rhodiola with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Karaya Gum with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Marshmallow with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Passion Flower with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Puravive with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Valerian with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Vitamin D with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Xanthan Gum with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Yerba Mate with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Calabar Bean with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Deanol with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Eleuthero with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Green Tea with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Gymnema with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Humann Superbeets Heart Chews with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Jequirity with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Milk Thistle with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Mommy's Bliss Gripe Water with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Polypodium Leucotomos with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer

Can you take Red Clover with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine Maleate, Dextromethorphan Hydrobromide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine Maleate, Dextromethorphan Hydrobromide through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine Maleate, Dextromethorphan Hydrobromide.

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Products that contain Chlorpheniramine Maleate, Dextromethorphan Hydrobromide-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit Calmhills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane
Pharmacist Counseling Corner

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide & Supplements: Common Questions

What supplements interact with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?
In our interaction database, 218 supplement and herbal ingredients have an interaction with Chlorpheniramine Maleate, Dextromethorphan Hydrobromide on file — 6 rated major, 170 moderate, and 42 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Henbane.
Which Chlorpheniramine Maleate, Dextromethorphan Hydrobromide supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Henbane, Lithium and Scopolia, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?
That depends entirely on which supplement. The honest answer for Chlorpheniramine Maleate, Dextromethorphan Hydrobromide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Coricidin HBP Cough & Cold have the same supplement interactions as Chlorpheniramine Maleate, Dextromethorphan Hydrobromide?
Yes — Coricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief all contain Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine Maleate, Dextromethorphan Hydrobromide and my other medications?
This page covers Chlorpheniramine Maleate, Dextromethorphan Hydrobromide against supplements and herbal ingredients. Checking Chlorpheniramine Maleate, Dextromethorphan Hydrobromide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.