Medication interaction hub

What Supplements Interact with Quetiapine?

Quetiapine brand names: Seroquel, Dopaquel. Every interaction below applies to the brands too.

199 Interactions 11 Major 147 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Quetiapine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Quetiapine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Quetiapine (Seroquel) treats schizophrenia and bipolar disorder, illnesses where an unplanned swing in the drug's blood level has real consequences, and that is why these 199 supplement interactions deserve a careful read rather than a shrug. Most of the risk runs through CYP3A4, the liver enzyme that clears quetiapine: grapefruit blocks that enzyme and can push levels up, while St. John's wort revs it up and can quietly drain the drug's effect.

Eleven of the 199 carry a major rating, and those deserve your attention ahead of the 147 moderates and 41 minors. Beyond the enzyme effects, some entries add sun sensitivity, a handful blunt absorption of anything swallowed (activated charcoal, itself rated major, binds medicines in the gut), and thirteen can stretch the heart's QT interval, the electrical reset between beats, an effect quetiapine can already have on its own.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 147 Minor 41 No known interaction 1,253

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Quetiapine: Top Interactions at a Glance

The Quetiapine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 199 interacting ingredients — plus 1,253 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Quetiapine Combinations Today

The Quetiapine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cannabis + Quetiapinei

Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Ashwagandha + Quetiapinei

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Read the full interaction Moderate Likelihood Possible Psilocybin + Quetiapinei

Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Read the full interaction Moderate Likelihood Probable Schisandra + Quetiapinei

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Kratom + Quetiapinei

Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndrome.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Quetiapinei

Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Quetiapine

All 1,452 ingredients in our database, ranked by severity — 199 with a Quetiapine interaction on file and 1,253 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Quetiapine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Quetiapine answer

Can you take Ashwagandha with Quetiapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Quetiapine answer

Can you take Psilocybin with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Full Psilocybin + Quetiapine answer

Can you take Schisandra with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Quetiapine answer

Can you take Kratom with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndr...

Full Kratom + Quetiapine answer

Can you take Gum Arabic with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Quetiapine answer

Can you take Hawaiian Baby Woodrose with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase the risk for serotonergic adverse effects.

Full Hawaiian Baby Woodrose + Quetiapine answer

Can you take Higenamine with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Higenamine + Quetiapine answer

Can you take Horny Goat Weed with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Quetiapine answer

Can you take Hu Zhang with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Full Hu Zhang + Quetiapine answer

Can you take Iboga with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drug...

Full Iboga + Quetiapine answer

Can you take Indian Long Pepper with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Quetiapine answer

Can you take K2/spice with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Quetiapine answer

Can you take Khat with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Khat may affect response to antipsychotic treatment.

Full Khat + Quetiapine answer

Can you take Khella with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Quetiapine answer

Can you take L-tryptophan with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + Quetiapine answer

Can you take Lemongrass with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Quetiapine answer

Can you take Lentinan with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2D6 (CYP2D6).

Full Lentinan + Quetiapine answer

Can you take Licorice with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Quetiapine answer

Can you take Light Therapy with Quetiapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Quetiapine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Quetiapine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Quetiapine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Quetiapine sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Quetiapine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Quetiapine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Quetiapine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Quetiapine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Quetiapine through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Quetiapine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Quetiapine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Quetiapine through this category.

Quetiapine (Seroquel) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Quetiapine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Quetiapine through this category.

About Quetiapine

An atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression.

Generic name: Quetiapine  ·  Brand names: Seroquel, Dopaquel.

See the full Quetiapine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Quetiapine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Quetiapine.

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Pharmacist Counseling Corner

Quetiapine & Supplements: Common Questions

What supplements interact with Quetiapine?
In our interaction database, 199 supplement and herbal ingredients have an interaction with Quetiapine on file — 11 rated major, 147 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Quetiapine supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Quetiapine?
That depends entirely on which supplement. The honest answer for Quetiapine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Seroquel have the same supplement interactions as Quetiapine?
Yes — Seroquel, Dopaquel all contain Quetiapine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Quetiapine and my other medications?
This page covers Quetiapine against supplements and herbal ingredients. Checking Quetiapine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Quetiapine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.