Drug & supplement interaction

Horseradish + Quetiapine

Quetiapine brand names: Seroquel, Dopaquel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Horseradish and Quetiapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Quetiapine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Horseradish and Quetiapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Quetiapine and Horseradish in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Horseradish safety at a glance

Horseradish overall Use caution Food amounts are generally safe, but concentrated supplements may irritate the digestive tract and mucous membranes.
Pregnancy Avoid Avoid medicinal amounts during pregnancy because safety has not been established.
Breastfeeding Likely Safe When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Quetiapine and Horseradish? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Quetiapine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Quetiapine is filed under 10 classifications — including antipsychotic drugs, qt interval-prolonging drugs, serotonergic drugs. Horseradish has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Quetiapine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Horseradish Does Interact With Other Medications

Horseradish has 16 moderate known drug interactions in our database — Quetiapine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Quetiapine)
Taking anything else?

Check Another of Your Medications Against Horseradish

Covers the 2,830 medications we’ve checked against Horseradish. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Horseradish and Quetiapine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Fainting Worth acting on Additional detail

    Horseradish

    “Orally, consuming large amounts of horseradish can cause vasovagal syncope in rare cases. At least two cases of vasovagal syncope associated with horseradish consumption have been reported. In one case, a 56-year-old male experienced a sharp burning sensation in his stomach followed by tachycardia, weakness, and excessive perspiration after consuming an oyster topped with an olive-sized dollop of fresh horseradish.”

    Horseradish · Natural Medicines adverse-effect record, reported in irregular heartbeat.

    1 source cited
    1. 111724. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

    Quetiapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Quetiapine. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Horseradish

    Recorded for Horseradish in the same Natural Medicines adverse-effect record shown under Fainting above.

    Quetiapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Quetiapine. Read the label on DailyMed ›

  • Sweating / A fast or pounding heartbeat Additional detail

    Horseradish

    Recorded for Horseradish in the same Natural Medicines adverse-effect record shown under Fainting above.

    Quetiapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Quetiapine. Read the label on DailyMed ›

  • Stomach upset / Diarrhea / Vomiting Additional detail

    Horseradish

    “Orally, consuming large amounts of horseradish can cause gastrointestinal upset, bloody vomiting and diarrhea (2,6), and irritation of mucous membranes (2,4).”

    Horseradish · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Quetiapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Quetiapine. Read the label on DailyMed ›

Effects for Quetiapine come from the ADVERSE REACTIONS section of its FDA label; effects for Horseradish come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 188,604 voluntary FDA FAERS reports for Quetiapine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Horseradish in Pregnancy & Breastfeeding

Lactation Likely Safe

When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US.

Lactation Likely Unsafe

When used orally in large amounts. The mustard oils produced by glucosinolates from horseradish are considered toxins that can be excreted through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Quetiapine Products Have a Food Rule — Horseradish Should Not Break It

At least one FDA label for a product containing Quetiapine says to take it on an empty stomach. Most supplements — Horseradish included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Quetiapine on its own and move Horseradish to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Quetiapine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

It is recommended that SEROQUEL XR be taken without food or with a light meal (approximately 300 calories) [see Clinical Pharmacology (12.3) ].

From the Dosage and Administration section of the FDA label we read for Quetiapine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Horseradish or Quetiapine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Horseradish or Quetiapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Quetiapine

This page covers Horseradish only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quetiapine page lists 199 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 147 moderate · 41 minor.

From our pharmacist’s overview on the Quetiapine page

“Quetiapine (Seroquel) treats schizophrenia and bipolar disorder, illnesses where an unplanned swing in the drug's blood level has real consequences, and that is why these 199 supplement interactions deserve a careful read rather than a shrug. Most of the risk runs through CYP3A4, the liver enzyme that clears quetiapine: grapefruit bloc…”

Reviewed by 2 · Jul 18, 2026

Open the Quetiapine interaction page

One more smart check

Taking Horseradish as Part of a Dietary Supplement Product? Check It for Interactions

We hold 245 real supplement products containing Horseradish, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Horseradish. Even though Horseradish itself has no known interaction with Quetiapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Horseradish and Quetiapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Horseradish
Top half

#543 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Quetiapine
Top 5%

#54 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Horseradish reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Horseradish and Quetiapine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Horseradish

What is Horseradish?

  • Sinus and respiratory congestion
  • Urinary tract infections
  • Digestive support
  • Antimicrobial
  • Culinary flavoring

Horseradish is a pungent root used as a food and folk remedy, most often for sinus congestion and urinary tract complaints. Human evidence is limited, and while culinary amounts are generally well tolerated, concentrated supplements can irritate the stomach and should be used cautiously. Talk with your pharmacist or doctor before using horseradish as a medicine.

Armoracia rusticana · Brassicaceae · Root (fresh or dried) · Fresh grated root, dried root powder, prepared condiment (sauce), capsules, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Horseradish is a good idea for someone in your situation. Here is what our Horseradish record says about it on its own.

Horseradish: dosing

There is no well-established standardized medicinal dose for horseradish. Amounts used in research and traditional practice vary widely depending on the form (fresh root, dried powder, or extract).If you use a commercial supplement, follow the directions on the product label and do not exceed the recommended amount. Avoid taking large or concentrated amounts in hopes of stronger effects, since this mainly increases the risk of irritation and side effects.

From our Horseradish monograph — the full record covers uses, side effects and every documented interaction.

Read the full Horseradish monograph & all interactions
Medication

About Quetiapine

What Is Quetiapine Used For?

Brand names: Seroquel, Dopaquel

Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes.

The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.

See full Quetiapine drug information
Keep checking

Other Drugs & Horseradish

Browse every other medication we’ve checked against Horseradish — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
16Moderate
0Minor
2,813No known interaction
16 Moderate 2,813 No interaction
Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Horseradish against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Horseradish list.

See the full Horseradish interactions page
See every supplement checked against Quetiapine, ranked by severity
Evidence & sources

Horseradish References

The 6 references that drive our Horseradish monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. PubMed
  6. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Horseradish and Quetiapine Together: Common Questions

Is it safe to take Horseradish with Quetiapine?
We do not list a known interaction between Horseradish and Quetiapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Horseradish and Quetiapine have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Horseradish and Quetiapine at the same time of day?
At least one FDA label for a product containing Quetiapine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Quetiapine on its own and move Horseradish to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Horseradish and Quetiapine combination checked?
Interactions in our licensed database are recorded against drug classes. Quetiapine is filed under 10 classifications, and Horseradish has documented interactions with 1 drug class — none of Quetiapine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Horseradish interact with any other medications?
Yes. Horseradish has 16 documented drug interactions in our database — Quetiapine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Quetiapine interact with any supplements?
Yes. Quetiapine has documented interactions with 199 supplements in our database — Horseradish is not one of them. The Quetiapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Horseradish monograph Uses, safety profile, and every drug interaction in one place Quetiapine drug information The full plain-English guide to this medication Quetiapine supplement interactions Every supplement checked against Quetiapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Quetiapine and Horseradish?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.