Drug & supplement interaction

Horseradish + Liothyronine

Liothyronine brand name: Cytomel.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Horseradish has a moderate interaction with Liothyronine. Theoretically, horseradish might interfere with the effects of thyroid hormone.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Horseradish and Liothyronine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

THYROID HORMONE

Why this applies to Liothyronine

Liothyronine falls under THYROID HORMONE — the group Horseradish interacts with.

Theoretically, horseradish might interfere with the effects of thyroid hormone.
Horseradish and other members of the cabbage and mustard family are associated with depressed thyroid function.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: liothyronine (Cytomel) is the active thyroid hormone T3, given to make up for what your thyroid isn't producing. Horseradish belongs to the cabbage and mustard family, and these plants contain compounds that, in theory, can nudge thyroid function downward. The worry is that regularly using concentrated horseradish supplements could work against your medication, leaving you a bit undertreated.

If that happened, you might notice the old hypothyroid symptoms creeping back, things like tiredness, feeling cold, weight gain, or sluggishness. I want to be honest though: this concern is theoretical and based on pharmacology, not real patient studies. A little horseradish on your food almost certainly won't matter. Before taking it as a daily remedy, just check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Horseradish Also Interacts With Other Medications

Horseradish has 15 moderate known drug interactions in our database — the Liothyronine one above is one of them. If you take anything else, check it against the full list below.

Moderate 15 No known interaction 2,815 (incl. Liothyronine)
Taking anything else?

Check Another of Your Medications Against Horseradish

Covers the 2,830 medications we’ve checked against Horseradish. Pick one to open its full report.

From our Q&A

Questions About Horseradish or Liothyronine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Horseradish or Liothyronine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Liothyronine

This page covers Horseradish only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liothyronine page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liothyronine page

“Liothyronine (Cytomel) is the active thyroid hormone T3, and it does not tolerate interference well. Of the 38 supplements and herbs on file, 21 act on thyroid function itself, some amplifying the hormone and others blunting it, iodine-rich seaweeds able to swing either way.”

Reviewed by 2 · Jul 18, 2026

Open the Liothyronine interaction page

One more smart check

Taking Horseradish as Part of a Dietary Supplement Product? Check It for Interactions

We hold 245 real supplement products containing Horseradish, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Horseradish. Your product may carry other ingredients that interact with Liothyronine too, on top of Horseradish — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Horseradish and Liothyronine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Horseradish
Top half

#519 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liothyronine
Top half

#865 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Horseradish

What is Horseradish?

  • Sinus and respiratory congestion
  • Urinary tract infections
  • Digestive support
  • Antimicrobial
  • Culinary flavoring

Horseradish is a pungent root used as a food and folk remedy, most often for sinus congestion and urinary tract complaints. Human evidence is limited, and while culinary amounts are generally well tolerated, concentrated supplements can irritate the stomach and should be used cautiously. Talk with your pharmacist or doctor before using horseradish as a medicine.

Read the full Horseradish monograph & all interactions
Medication

About Liothyronine

What Is Liothyronine Used For?

Brand name: Cytomel

Liothyronine (available as tablets under the brand names Cytomel, Liomny, and Liothyronine Sodium, and as an injection under Liothyronine Sodium and Triostat) is primarily used to treat hypothyroidism (an underactive thyroid) across all its forms — whether the cause is in the thyroid itself, the pituitary gland, or the hypothalamus, and whether it was present at birth or developed over time.

The oral tablets are also used alongside surgery and radioiodine therapy to suppress TSH (thyroid-stimulating hormone) in people with well-differentiated thyroid cancer, and as a diagnostic agent in thyroid suppression tests. Liothyronine sodium injection is specifically indicated for myxedema coma (a life-threatening form of severe hypothyroidism) and may be used in patients who are allergic to thyroid products derived from pork or beef.

See full Liothyronine drug information
Keep checking

Other Drugs & Horseradish

Browse every other medication we’ve checked against Horseradish — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
15Moderate
0Minor
2,814No known interaction
15 Moderate 2,814 No interaction
Moderate

15 interactions

No interaction 2,814 drugs checked — show the list

We also checked Horseradish against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,814 medications checked with no known interaction — see the full Horseradish list.

See the full Horseradish interactions page
See every supplement checked against Liothyronine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Horseradish monograph › Uses, safety, and every drug interaction in one place Liothyronine supplement interactions › Every supplement checked against Liothyronine, ranked by severity Liothyronine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Horseradish and Liothyronine Together: Common Questions

Can you take Horseradish with Liothyronine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Horseradish and Liothyronine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Liothyronine and Horseradish?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.