Medication interaction hub

What Supplements Interact with Liothyronine?

Liothyronine brand name: Cytomel. Every interaction below applies to the brands too.

38 Interactions 2 Major 26 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Liothyronine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Liothyronine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Liothyronine (Cytomel) is the active thyroid hormone T3, and it does not tolerate interference well. Of the 38 supplements and herbs on file, 21 act on thyroid function itself, some amplifying the hormone and others blunting it, iodine-rich seaweeds able to swing either way. The two major-rated entries come first: tiratricol, a thyroid hormone in its own right that stacks on your prescription, and activated charcoal, which can soak up your dose before it reaches your blood.

The other 17 interfere with absorption, mostly fibers, gums, and charcoals that trap oral medicines in the gut; spacing those well apart from your liothyronine handles most of that risk. Behind the two majors sit 26 moderate and 10 minor entries, so not every pairing is an emergency, but on a hormone where labs are tuned to a narrow target, small shifts become symptoms.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 26 Minor 10 No known interaction 1,414

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Liothyronine: Top Interactions at a Glance

The Liothyronine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 38 interacting ingredients — plus 1,414 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Liothyronine Combinations Today

The Liothyronine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Bacopa + Liothyroninei

Theoretically, bacopa might have additive effects when used with thyroid hormone.

Read the full interaction Moderate Likelihood Probable L-carnitine + Liothyroninei

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Read the full interaction Moderate Likelihood Possible Lemon Balm + Liothyroninei

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.

Read the full interaction Moderate Likelihood Possible Guar Gum + Liothyroninei

Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Read the full interaction Major Likelihood Probable Activated Charcoal + Liothyroninei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Tiratricol + Liothyroninei

Concomitant use of tiratricol with thyroid hormones may have additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Liothyronine

All 1,452 ingredients in our database, ranked by severity — 38 with a Liothyronine interaction on file and 1,414 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Liothyronine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bacopa with Liothyronine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bacopa might have additive effects when used with thyroid hormone.

Full Bacopa + Liothyronine answer

Can you take L-carnitine with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full L-carnitine + Liothyronine answer

Can you take Lemon Balm with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.

Full Lemon Balm + Liothyronine answer

Can you take Guar Gum with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Liothyronine answer

Can you take Guggul with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.

Full Guggul + Liothyronine answer

Can you take Niacin with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.

Full Niacin + Liothyronine answer

Can you take Tyrosine with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tyrosine might have additive effects with thyroid hormone medications.

Full Tyrosine + Liothyronine answer

Can you take Alpha-lipoic Acid with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.

Full Alpha-lipoic Acid + Liothyronine answer

Can you take Ascophyllum Nodosum with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.

Full Ascophyllum Nodosum + Liothyronine answer

Can you take Cassava with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human and animal research suggests that cassava root has marked antithyroid effects, particularly if poorly processed or if co...

Full Cassava + Liothyronine answer

Can you take Dulse with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, due to its iodine content, dulse might alter the effects of thyroid hormone.

Full Dulse + Liothyronine answer

Can you take Fucus Vesiculosus with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.

Full Fucus Vesiculosus + Liothyronine answer

Can you take Fulvic Acid with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.

Full Fulvic Acid + Liothyronine answer

Can you take Gum Arabic with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Liothyronine answer

Can you take Horseradish with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horseradish might interfere with the effects of thyroid hormone.

Full Horseradish + Liothyronine answer

Can you take Laminaria with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, laminaria might alter the effects of thyroid hormone.

Full Laminaria + Liothyronine answer

Can you take Propionyl-l-carnitine with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full Propionyl-l-carnitine + Liothyronine answer

Can you take Sea Moss with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, sea moss might alter the effects of thyroid hormone.

Full Sea Moss + Liothyronine answer

Can you take Shepherd's Purse with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with thyroid dysfunction therapy.

Full Shepherd's Purse + Liothyronine answer

Can you take Slippery Elm with Liothyronine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Liothyronine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Liothyronine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Liothyronine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Liothyronine sits in 2 interaction categories. Open any one to see what the group means:

Thyroid Hormone 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Liothyronine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Liothyronine through this category.

About Liothyronine

Liothyronine is a thyroid agent used to treat hypothyroidism and other thyroid conditions.

Generic name: Liothyronine  ·  Brand name: Cytomel.

See the full Liothyronine drug information
Check a real product

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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Liothyronine.

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Pharmacist Counseling Corner

Liothyronine & Supplements: Common Questions

What supplements interact with Liothyronine?
More than you might expect — 38 in total, though they are far from equal: 2 are rated major, 26 moderate, and 10 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Tiratricol, Acetyl-l-carnitine.
Which Liothyronine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Tiratricol. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Liothyronine?
Usually yes — most people on Liothyronine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Cytomel have the same supplement interactions as Liothyronine?
Yes — Cytomel all contain Liothyronine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Liothyronine and my other medications?
This page covers Liothyronine against supplements and herbal ingredients. Checking Liothyronine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Liothyronine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.