Liothyronine

31 interactions 108 cited references
Also sold as: Cytomel Cytomel® Liomny
About Liothyronine

Liothyronine is a thyroid agent used to treat hypothyroidism and other thyroid conditions. Read the full Liothyronine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iomeprol Midodrine Iopromide Furosemide Insulin Aspart, Recombinant Insulin Glargine, Recombinant
10 Major 15 Moderate 6 Minor
All (31) Major (10) Moderate (15) Minor (6)

Major

Liothyronine Digoxin Cardoxin® Reduced digoxin exposure Details Liothyronine Furosemide Injection Disal Increased risk of free thyroid hormones, followed by an overall decrease in total thyroid hormone levels Details Liothyronine Iomeprol Injection Reduced efficacy of thyroid therapy Details Liothyronine Furosemide Disal Increased risk of free thyroid hormones, followed by an overall decrease in total thyroid hormone levels Details Liothyronine Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Liothyronine Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Liothyronine Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Liothyronine Iomeprol Reduced efficacy of thyroid therapy Details Liothyronine Iopromide Reduced efficacy of thyroid hormones Details Liothyronine Midodrine Orvaten® Increased risk of hypertension Details

Moderate

Liothyronine Cholestyramine Resin Locholest® Decreased effectiveness of liothyronine Details Liothyronine Colesevelam Welchol Decreased effectiveness of liothyronine Details Liothyronine Colestipol Colestid Decreased effectiveness of liothyronine Details Liothyronine Levonorgestrel After banger Reduced thyroid hormone replacement exposure Details Liothyronine Levonorgestrel Intrauterine System Kyleena Reduced thyroid hormone replacement exposure Details Liothyronine Bugleweed Reduced effectiveness of thyroid hormones Details Liothyronine Cholestyramine Prevalite Decreased effectiveness of liothyronine Details Liothyronine Ethinyl Estradiol Reduced liothyronine exposure Details Liothyronine Insulin Afrezza May decrease blood glucose lowering effect of insulin Details Liothyronine Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Liothyronine Kelp Increased risk of hypo- or hyperthyroidism, altered thyroid hormone dosage requirements, and inaccurate thyroid function tests use... Details Liothyronine Lithospermum Reduced effectiveness of thyroid hormones Details Liothyronine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Liothyronine Sevelamer RenaGel Decreased liothyronine effectiveness Details Liothyronine Sodium Polystyrene Sulfonate Kalexate® Decreased liothyronine effectiveness Details

Minor

Liothyronine Acenocoumarol An increased risk of bleeding Details Liothyronine Anisindione An increased risk of bleeding Details Liothyronine Dicumarol An increased risk of bleeding Details Liothyronine Phenindione An increased risk of bleeding Details Liothyronine Phenprocoumon An increased risk of bleeding Details Liothyronine Warfarin Coumadin An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.