Liothyronine

Name: Liothyronine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

31 interactions 108 cited references

Also sold as: Cytomel Cytomel® Liomny

About Liothyronine

Liothyronine is a thyroid agent used to treat hypothyroidism and other thyroid conditions. Read the full Liothyronine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iomeprol Midodrine Iopromide Furosemide Insulin Aspart, Recombinant Insulin Glargine, Recombinant

10 Major 15 Moderate 6 Minor

All (31) Major (10) Moderate (15) Minor (6)

Major

Liothyronine Digoxin Cardoxin® Reduced digoxin exposure Details Liothyronine Furosemide Injection Disal Increased risk of free thyroid hormones, followed by an overall decrease in total thyroid hormone levels Details Liothyronine Iomeprol Injection Reduced efficacy of thyroid therapy Details Liothyronine Furosemide Disal Increased risk of free thyroid hormones, followed by an overall decrease in total thyroid hormone levels Details Liothyronine Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Liothyronine Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Liothyronine Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Liothyronine Iomeprol Reduced efficacy of thyroid therapy Details Liothyronine Iopromide Reduced efficacy of thyroid hormones Details Liothyronine Midodrine Orvaten® Increased risk of hypertension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.