Drug & supplement interaction

Bacopa + Liothyronine

Liothyronine brand name: Cytomel.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Bacopa has a minor interaction with Liothyronine. Theoretically, bacopa might have additive effects when used with thyroid hormone.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Bacopa and Liothyronine

Here is the interaction we found between these two, with the evidence behind it.

Minor

THYROID HORMONE

Why this applies to Liothyronine

Liothyronine falls under THYROID HORMONE — the group Bacopa interacts with.

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: liothyronine (Cytomel) is the active thyroid hormone T3, so it goes right to work in your body without needing to be switched on first. The concern on file is that bacopa might gently push your thyroid hormone levels in the same direction. In one mouse study, bacopa raised T4 by roughly 40 percent. If something similar happened in people, stacking it on top of your liothyronine could theoretically nudge you toward too much thyroid hormone, with signs like a racing or pounding heart, feeling jittery or warm, trouble sleeping, or unexpected weight loss.

That said, this is a theoretical flag drawn from animal data, rated minor, so I wouldn't panic. Still, since thyroid dosing is finicky, please run it by your pharmacist or doctor before adding bacopa.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bacopa Also Interacts With Other Medications

Bacopa has 917 moderate, 12 minor known drug interactions in our database — the Liothyronine one above is one of them. If you take anything else, check it against the full list below.

Moderate 917 Minor 12 No known interaction 1,901 (incl. Liothyronine)
Taking anything else?

Check Another of Your Medications Against Bacopa

Covers the 2,830 medications we’ve checked against Bacopa. Pick one to open its full report.

From our Q&A

Questions About Bacopa or Liothyronine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bacopa or Liothyronine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Liothyronine

This page covers Bacopa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liothyronine page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liothyronine page

“Liothyronine (Cytomel) is the active thyroid hormone T3, and it does not tolerate interference well. Of the 38 supplements and herbs on file, 21 act on thyroid function itself, some amplifying the hormone and others blunting it, iodine-rich seaweeds able to swing either way.”

Reviewed by 2 · Jul 18, 2026

Open the Liothyronine interaction page

One more smart check

Taking Bacopa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,420 real supplement products containing Bacopa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bacopa. Your product may carry other ingredients that interact with Liothyronine too, on top of Bacopa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bacopa and Liothyronine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bacopa
Top 10%

#140 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liothyronine
Top half

#736 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bacopa

What is Bacopa?

Bacopa
  • Memory and cognitive support
  • Anxiety and stress
  • ADHD symptoms
  • Age-related memory decline
  • General brain health

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limited and quality varies. It is generally well tolerated but can cause stomach upset, and it should be avoided in pregnancy and breastfeeding due to a lack of safety data.

Read the full Bacopa monograph & all interactions
Medication

About Liothyronine

What Is Liothyronine Used For?

Brand name: Cytomel

Liothyronine (available as tablets under the brand names Cytomel, Liomny, and Liothyronine Sodium, and as an injection under Liothyronine Sodium and Triostat) is primarily used to treat hypothyroidism (an underactive thyroid) across all its forms — whether the cause is in the thyroid itself, the pituitary gland, or the hypothalamus, and whether it was present at birth or developed over time.

The oral tablets are also used alongside surgery and radioiodine therapy to suppress TSH (thyroid-stimulating hormone) in people with well-differentiated thyroid cancer, and as a diagnostic agent in thyroid suppression tests. Liothyronine sodium injection is specifically indicated for myxedema coma (a life-threatening form of severe hypothyroidism) and may be used in patients who are allergic to thyroid products derived from pork or beef.

See full Liothyronine drug information
Keep checking

Other Drugs & Bacopa

Browse every other medication we’ve checked against Bacopa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
917Moderate
12Minor
1,900No known interaction
917 Moderate 12 Minor 1,900 No interaction
Moderate

917 interactions

Showing 60 of 917 moderate interactions — see all 917 on the Bacopa page.

Minor

12 interactions

No interaction 1,900 drugs checked — show the list

We also checked Bacopa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,900 medications checked with no known interaction — see the full Bacopa list.

See the full Bacopa interactions page
See every supplement checked against Liothyronine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bacopa monograph › Uses, safety, and every drug interaction in one place Liothyronine supplement interactions › Every supplement checked against Liothyronine, ranked by severity Liothyronine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bacopa and Liothyronine Together: Common Questions

Can you take Bacopa with Liothyronine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bacopa and Liothyronine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Liothyronine and Bacopa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.