Drug & supplement interaction

Bacopa + Dextrothyroxine

Dextrothyroxine brand name: Choloxin.

Minor Interaction
Medically reviewed by · Updated October 2026
The bottom line Minor

Bacopa has a minor interaction with Dextrothyroxine. Theoretically, bacopa might have additive effects when used with thyroid hormone.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Bacopa and Dextrothyroxine

Here is the interaction we found between these two, with the evidence behind it.

Minor

THYROID HORMONE

Why this applies to Dextrothyroxine

Dextrothyroxine falls under THYROID HORMONE — the group Bacopa interacts with.

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with bacopa and dextrothyroxine (Choloxin). Dextrothyroxine is a thyroid hormone medication, and the concern on file is that bacopa might add to its effect. In mouse studies, bacopa bumped up T4 (thyroxine) levels by roughly 40%. The thinking is that taking the two together could push your thyroid activity a little higher than intended.

If that happened, you might notice things like a faster or pounding heartbeat, feeling jittery or anxious, trouble sleeping, or unexpected weight changes. That said, I want to be honest: this is a theoretical interaction based on animal data, not proven in people, and it's rated minor. I wouldn't lose sleep over it, but since thyroid dosing is sensitive, just give your pharmacist or doctor a heads-up before adding regular bacopa.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bacopa Also Interacts With Other Medications

Bacopa has 919 moderate, 12 minor known drug interactions in our database — the Dextrothyroxine one above is one of them. If you take anything else, check it against the full list below.

Moderate 919 Minor 12 No known interaction 1,899 (incl. Dextrothyroxine)
Taking anything else?

Check Another of Your Medications Against Bacopa

Covers the 2,830 medications we’ve checked against Bacopa. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dextrothyroxine

This page covers Bacopa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextrothyroxine page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Dextrothyroxine page

“Activated charcoal is the risk I would flag first with dextrothyroxine (Choloxin), a thyroid hormone once used to lower cholesterol. Charcoal binds drugs in the gut and can strip away much of a dose, and it is one of only two major-rated interactions among the 38 supplements on file here.”

Reviewed by 2 · Jul 18, 2026

Open the Dextrothyroxine interaction page

One more smart check

Taking Bacopa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,420 real supplement products containing Bacopa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bacopa. Your product may carry other ingredients that interact with Dextrothyroxine too, on top of Bacopa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bacopa and Dextrothyroxine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bacopa
Top 10%

#142 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextrothyroxine
Top 25%

#635 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bacopa

What is Bacopa?

Bacopa
  • Memory and cognitive support
  • Anxiety and stress
  • ADHD symptoms
  • Age-related memory decline
  • General brain health

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limited and quality varies. It is generally well tolerated but can cause stomach upset, and it should be avoided in pregnancy and breastfeeding due to a lack of safety data.

Read the full Bacopa monograph & all interactions
Keep checking

Other Drugs & Bacopa

Browse every other medication we’ve checked against Bacopa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
919Moderate
12Minor
1,898No known interaction
919 Moderate 12 Minor 1,898 No interaction
Moderate

919 interactions

Showing 60 of 919 moderate interactions — see all 919 on the Bacopa page.

Minor

12 interactions

No interaction 1,898 drugs checked — show the list

We also checked Bacopa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,898 medications checked with no known interaction — see the full Bacopa list.

See the full Bacopa interactions page
See every supplement checked against Dextrothyroxine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bacopa monograph › Uses, safety, and every drug interaction in one place Dextrothyroxine supplement interactions › Every supplement checked against Dextrothyroxine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bacopa and Dextrothyroxine Together: Common Questions

Can you take Bacopa with Dextrothyroxine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bacopa and Dextrothyroxine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dextrothyroxine and Bacopa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.